mesangial

• 糸球体間質の

関

glomerular mesangium、mesangium

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/03/15 09:07:48」(JST)

wiki en

[Wiki en表示]

Renal corpuscle. The entire structure is the renal corpuscle. The blue structure (A) is the Bowman's capsule (2 and 3). The pink structure is the glomerulus with its capillaries. At the left, blood flows from the afferent arteriole (9), through the capillaries (10), and out the efferent arteriole (11). The mesangium (5a, 5b) is the purple structure inside the glomerulus between the capillaries and extending outside the glomerulus.

In the glomerulus of the kidney, the mesangium is a structure associated with the capillaries. It is continuous with the smooth muscles of the arterioles. It is outside the capillary lumen, but surrounded by capillaries. It is in the middle (meso) between the capillaries (angis). It is contained by the basement membrane, which surrounds both the capillaries and the mesangium.

This term is often used interchangeably with mesangial cell, but in this context refers specifically to the intraglomerular mesangial cells. These cells are phagocytic and secrete the amorphous basement membrane-like material known as the mesangial matrix. They are typically separated from the lumen of the capillaries by endothelial cells.

References

Further reading

• Nielsen, S.; Kwon, T.H.; Fenton, R.A.; Praetorious, J. (2012). "Anatomy of the Kidney". In Rector, F. C.; Brenner, B. M. Brenner & Rector's the kidney. 1 (9th ed.). Philadelphia: Elsevier Saunders. pp. 31–93. ISBN 978-1-4160-6193-9. 
• Kriz, W; Elger, M; Mundel, P; Lemley, K. V (1995). "Structure-stabilizing forces in the glomerular tuft". Journal of the American Society of Nephrology. 5 (10): 1731–9. PMID 7787139. 
• Schlöndorff, Detlef (1996). "Roles of the mesangium in glomerular function". Kidney International. 49 (6): 1583–5. doi:10.1038/ki.1996.229. PMID 8743459. 
• Phua, Yu Leng; Chu, Jessica Y. S; Marrone, April K; Bodnar, Andrew J; Sims‐Lucas, Sunder; Ho, Jacqueline (2015). "Renal stromal miRNAs are required for normal nephrogenesis and glomerular mesangial survival". Physiological Reports. 3 (10): e12537. doi:10.14814/phy2.12537. PMC 4632944 . PMID 26438731. 

External links

• Physiology: 7/7ch03/7ch03p12 - Essentials of Human Physiology
• "Mesangium" at Dorland's Medical Dictionary

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. IgA腎症の病因 pathogenesis of iga nephropathy
• 2. IgA腎症の治療および予後 treatment and prognosis of iga nephropathy
• 3. 微小変化群の亜型：メサンギウム増殖、IgM腎症、C1q腎症 minimal change variants mesangial proliferation igm nephropathy c1q nephropathy
• 4. 全身性エリテマトーデスにおける腎疾患の診断および分類 diagnosis and classification of renal disease in systemic lupus erythematosus
• 5. 糸球体の免疫障害の機序 mechanisms of immune injury of the glomerulus

English Journal

• The renal effects of mineralocorticoid receptor antagonists.

• Bianchi S1, Batini V2, Bigazzi R2.
• International journal of cardiology.Int J Cardiol.2015 Dec 1;200:20-4. doi: 10.1016/j.ijcard.2015.05.125. Epub 2015 May 22.
• Beyond its well known classic effects on renal water and electrolytes metabolism, an increasing amount of experimental and clinical evidence suggests that aldosterone contributes to the pathogenesis and progression of kidney disease. The binding of aldosterone on epithelial and non-epithelial cells
• PMID 26049733

• Podocyte-specific deletion of Rac1 leads to aggravation of renal injury in STZ-induced diabetic mice.

• Ishizaka M1, Gohda T2, Takagi M1, Omote K1, Sonoda Y1, Oliva Trejo JA3, Asao R1, Hidaka T1, Asanuma K4, Horikoshi S1, Tomino Y5.
• Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Nov 20;467(3):549-555. doi: 10.1016/j.bbrc.2015.09.158. Epub 2015 Oct 21.
• Rac1, a GTPase of the Rho subfamily, has a crucial role in cytoskeletal architecture, as well as the regulation of cell migration and growth. However, renal injury in mice with podocyte-specific deletion of Rac1 has yet to be elucidated fully due to conflicting findings. Herein, we identified a poss
• PMID 26435502

• The development of a virtual 3D model of the renal corpuscle from serial histological sections for E-learning environments.

• Roth JA1, Wilson TD2,3, Sandig M2,3.
• Anatomical sciences education.Anat Sci Educ.2015 Nov 12;8(6):574-583. doi: 10.1002/ase.1529. Epub 2015 Mar 23.
• Histology is a core subject in the anatomical sciences where learners are challenged to interpret two-dimensional (2D) information (gained from histological sections) to extrapolate and understand the three-dimensional (3D) morphology of cells, tissues, and organs. In gross anatomical education 3D m
• PMID 25808044

Japanese Journal

• Identification of cysteinylated transthyretin, a predictive biomarker of treatment response to partially hydrolyzed guar gum in type 2 diabetes rats, by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry

• Journal of Clinical Biochemistry and Nutrition 58(1), 23-33, 2016
• NAID 130005116636

• ONO-1301, a Sustained-Release Prostacyclin Analog, Ameliorates the Renal Alterations in a Mouse Type 2 Diabetes Model Possibly Through Its Protective Effects on Mesangial Cells

• Acta Medica Okayama 69(1), 1-15, 2015-02
• NAID 120005549937

• 糖尿病性腎症の発症にコレステロールを含む凝集タンパク質は関係しているか? : AGE-コレステロール凝集タンパク質は腎メサンギウム細胞においてlysosomal enzymeによって分解される

• 名城大学総合研究所紀要 (20), 77-80, 2015
• NAID 40020591645

Related Pictures

---

★リンクテーブル★

リンク元	「糸球体間質」「glomerular mesangium」
拡張検索	「renal mesangial cell」「kidney mesangial cell」「mesangial proliferative glomerulonephritis」

「糸球体間質」

　　[★]

英

glomerular mesangium、mesangium、mesangial

関

メサンギウム

「glomerular mesangium」

　　[★]

糸球体間質

関

mesangial、mesangium

「renal mesangial cell」

　　[★]

• 腎メサンギウム細胞

関

glomerular mesangial cell、kidney mesangial cell、mesangial cell

「kidney mesangial cell」

　　[★]

• 腎メサンギウム細胞

関

glomerular mesangial cell、mesangial cell、renal mesangial cell

「mesangial proliferative glomerulonephritis」

　　[★] メサンギウム増殖性糸球体腎炎