mercaptopurine

出典: meddic

6-メルカプトプリン

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「a drug (trade name Purinethol) that interferes with the metabolism of purine and is used to treat acute lymphocytic leukemia」
Purinethol

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/21 01:19:42」(JST)

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英文文献

  • The circadian schedule for childhood acute lymphoblastic leukemia maintenance therapy does not influence event-free survival in the NOPHO ALL92 protocol.
  • Clemmensen KK, Christensen RH, Shabaneh DN, Harila-Saari A, Heyman M, Jonsson OG, Wesenberg F, Rosthøj S, Schmiegelow K; Nordic Society of Pediatric Hematology, Oncology (NOPHO).Author information Clinic for Pediatrics and Adolescent Medicine, The Juliane Marie Centre, The University Hospital Rigshospitalet, Copenhagen, Denmark.AbstractBACKGROUND: The event-free survival of childhood acute lymphoblastic leukemia (ALL) has been reported to be superior when oral methotrexate (MTX) and 6-mercaptopurine (6MP) maintenance therapy (MT) is administered in the evening compared to the morning.
  • Pediatric blood & cancer.Pediatr Blood Cancer.2014 Apr;61(4):653-8. doi: 10.1002/pbc.24867. Epub 2013 Nov 22.
  • BACKGROUND: The event-free survival of childhood acute lymphoblastic leukemia (ALL) has been reported to be superior when oral methotrexate (MTX) and 6-mercaptopurine (6MP) maintenance therapy (MT) is administered in the evening compared to the morning.PROCEDURE: In the ALL92 MT study we prospective
  • PMID 24265159
  • Adverse events in IBD: to stop or continue immune suppressant and biologic treatment.
  • McLean LP, Cross RK.Author information Department of Medicine, Division of Gastroenterology and Hepatology University of Maryland, 100 North Greene Street, Lower Level, Baltimore, MD 21201, USA.AbstractCrohn's disease and ulcerative colitis affect an increasing number of patients. A variety of medical options exist for the treatment of these diseases including immune suppressants and biologic therapies. Unfortunately, these agents are associated with adverse events ranging from mild nuisance symptoms to potentially life-threatening complications including infections and malignancies. This review discusses adverse events associated with azathioprine, mercaptopurine, and methotrexate as well as anti-TNF-α and anti-integrin antibodies. In addition, adverse events associated with combination therapy are discussed as are clinical scenarios in which it may be reasonable to discontinue or de-escalate drug therapy. It is the responsibility of the treating gastroenterologist to effectively communicate the benefits and risks of therapy with patients; this review offers strategies that may assist providers in communicating risk with patients in addition to offering our perspective on whether modification or cessation of therapy can be considered.
  • Expert review of gastroenterology & hepatology.Expert Rev Gastroenterol Hepatol.2014 Mar;8(3):223-40. doi: 10.1586/17474124.2014.881715. Epub 2014 Feb 4.
  • Crohn's disease and ulcerative colitis affect an increasing number of patients. A variety of medical options exist for the treatment of these diseases including immune suppressants and biologic therapies. Unfortunately, these agents are associated with adverse events ranging from mild nuisance sympt
  • PMID 24490595
  • Intrauterine exposure and pharmacology of conventional thiopurine therapy in pregnant patients with inflammatory bowel disease.
  • Jharap B, de Boer NK, Stokkers P, Hommes DW, Oldenburg B, Dijkstra G, van der Woude CJ, de Jong DJ, Mulder CJ, van Elburg RM, van Bodegraven AA; Dutch Initiative on Crohn and Colitis.Author information Department of Gastroenterology and Hepatology, VU University Medical Center, , Amsterdam, The Netherlands.AbstractOBJECTIVE: Several studies have demonstrated a favourable safety profile for thiopurine use for inflammatory bowel disease (IBD) during pregnancy. We performed a study in pregnant patients with IBD who were using thiopurines, in order to determine the influence of pregnancy on thiopurine metabolism and to assess intrauterine exposure of the fetus to thiopurines.
  • Gut.Gut.2014 Mar;63(3):451-7. doi: 10.1136/gutjnl-2012-303615. Epub 2013 Feb 19.
  • OBJECTIVE: Several studies have demonstrated a favourable safety profile for thiopurine use for inflammatory bowel disease (IBD) during pregnancy. We performed a study in pregnant patients with IBD who were using thiopurines, in order to determine the influence of pregnancy on thiopurine metabolism
  • PMID 23424097

和文文献

  • 6-Mercaptopurine-induced histopathological changes and xanthine oxidase expression in rat placenta
  • Taki Kenji,Fukushima Tamio,Ise Ryota [他],HORII Ikuo,YOSHIDA Takemi
  • Journal of toxicological sciences 37(3), 607-615, 2012-06-01
  • NAID 10030436433
  • Assessment of Combined Therapy with Purine Derivatives and Infliximab in Patients with Refractory Crohn's Disease
  • SATOH Mitsutoshi,TSUCHIYA Mari,YAMAUCHI Takiyo,DOI Hirokazu,MASAKA Toru,SUZUKI Yasuo
  • 応用薬理 82(1), 1-8, 2012-04-06
  • NAID 10030512768
  • チオプリン製剤投与により急性膵炎を発症した炎症性腸疾患の2例
  • 西川 潤,工藤 俊彦,宮嵜 孝子,三原 弘,植田 亮,安藤 孝将,梶浦 新也,藤浪 斗,小川 浩平,細川 歩,杉山 敏郎
  • 日本消化器病學會雜誌 = The Japanese journal of gastro-enterology 109(2), 224-230, 2012-02-05
  • … チオプリン製剤投与により急性膵炎を発症した炎症性腸疾患2例を経験した.症例1は25歳のクローン病患者で,azathioprineによる膵炎が意図せぬ再投与により確認された.症例2は13歳の潰瘍性大腸炎患者でazathioprineにより膵炎をきたし,6-mercaptopurineで膵炎の再発を認めた.2例ともチオプリン開始後3~4週で膵炎を発症し,投与中止により速やかに改善した. …
  • NAID 10030310433

関連リンク

Mercaptopurineとは?goo Wikipedia (ウィキペディア) 。出典:Wikipedia(ウィキペディア)フリー百科事典。 Mercaptopurineとは - goo Wikipedia (ウィキペディア) gooトップ サイトマップ スタートページに設定 RSS ヘルプ メニューへ 本文へ ...
Read more about the pharmacogenomics of mercaptopurine on PharmGKB. ... Phenotype (Genotype) Therapeutic Dose Recommendation Level of Evidence Clinical Relevance IM (one inactive allele: *2, *3, *4-*18) Select ...

関連画像

Nom UICPA MercaptopurineMercaptopurinePeople on mercaptopurine are susceptible Description Mercaptopurine 3D ball.pngFichier:Mercaptopurine.jpgMethyl-6-mercaptopurine


★リンクテーブル★
先読み6-メルカプトプリン
リンク元purinethol
拡張検索6-mercaptopurine riboside」「mercaptopurine hydrate」「6-mercaptopurine

6-メルカプトプリン」

  [★]

6-mercaptopurine, mercaptopunne
6-mercaptopurinum
6-MP
ロイケリン
アザチオプリン制癌薬


  • 白血病治療薬
  • プリンの6位にSが付加された物質。

代謝

作用機序

  • TIMPがプリン塩基の生合成を阻害する
本剤は、細胞増殖重要意義をもつ核酸生合成阻害する。メルカプトプリン細胞内inosinic acidのチオ同族体 thioinosinic acid(TIMP)に変換し、このTIMPは主としてinosinic acid からのadenylosuccinic acid 及びxanthylic acidへの転換阻害し、adenine, guanineribonucleotideの生合成阻害するとされている

適応

  • 急性白血病、慢性骨髄性白血病
  • 白血病、悪性リンパ腫以外の腫瘍に対しては効果が少なく適応されない

注意

重大な副作用

  • 骨髄抑制

添付文書

  • ロイケリン散10%
http://www.info.pmda.go.jp/go/pack/4221001B1052_1_02/4221001B1052_1_02?view=body



purinethol」

  [★]

6MP, Purinethol
6-Mercaptopurine
mercaptopurine


6-mercaptopurine riboside」

  [★]

6-メルカプトプリンリボシド

thioinosine


mercaptopurine hydrate」

  [★]

mercaptopurine


6-mercaptopurine」

  [★] 6-メルカプトプリン




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