medullary carcinoma of thyroid

甲状腺髄様癌

WordNet

1. of or relating to the medulla of any body part
2. containing or consisting of or resembling bone marrow
3. of or relating to the medulla oblongata
4. suggestive of a thyroid disorder; "thyroid personality"
5. of or relating to the thyroid gland; "thyroid deficiency"; "thyroidal uptake" (同)thyroidal
6. the inner part of an organ or structure in plant or animal
7. any malignant tumor derived from epithelial tissue; one of the four major types of cancer

PrepTutorEJDIC

1. 《所有・所属》…『の』,…のものである,…に属する・《材料・要素》…『でできた』,から成る・《部分》…『の』[『中の』] ・《数量・単位・種類を表す名詞に付いて》…の・《原因・動機》…『で』,のために(because of) ・《主格関係》…『の』,による,によって・《目的格関係》…『を』,の・《同格関係》…『という』・《関係・関連》…『についての』[『の』],の点で・《抽象名詞などと共に》…の[性質をもつ] ・《『It is』+『形』+『of』+『名』+『to』 doの形で,ofの後の名詞を意味上の主語として》・《分離》…『から』・《起原・出所》…『から』[『の』](out of) ・《『名』+『of』+『a』(『an』)+『名』の形で》…のような・《『名』+『of』+『mine』(『yours, his』など独立所有格)の形で》…の…・《時》(1)《副詞句を作って》…に《形容詞句を作って》…の・《時刻》《米》…前(to,《米》before)
2. 甲状腺 / 甲状腺の
3. 〈U〉骨髄 / =medulla oblongata
4. がん,がん腫

UpToDate Contents

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• 1. 甲状腺髄様癌：臨床症状、診断、および病期分類medullary thyroid cancer clinical manifestations diagnosis and staging [show details]
  … Medullary thyroid cancer (MTC) is a neuroendocrine tumor of the parafollicular or C cells of the thyroid gland. MTC accounts for approximately 1 to 2 percent of thyroid cancers in the United States . …
• 2. 甲状腺髄様癌：全身療法および免疫療法medullary thyroid cancer systemic therapy and immunotherapy [show details]
  …experimental chemotherapies for advanced medullary thyroid carcinomas will be reviewed here. Chemotherapies for differentiated and anaplastic thyroid carcinomas are discussed separately. The availability …
• 3. 甲状腺髄様癌：手術および予後medullary thyroid cancer surgical treatment and prognosis [show details]
  … Patients with medullary thyroid cancer (MTC) can be cured only by complete resection of the thyroid tumor and any local and regional metastases. For patients with residual or recurrent disease after primary …
• 4. 分化型甲状腺癌：マネージメントの概要differentiated thyroid cancer overview of management [show details]
  … differentiated cancers. The treatment of anaplastic thyroid cancer is reviewed separately. Other malignant diseases of the thyroid include medullary thyroid cancer (MTC) (which can be familial, either as part …
• 5. 小児における甲状腺結節および癌thyroid nodules and cancer in children [show details]
  …are noninvasive. Follicular thyroid cancer (FTC) – Follicular carcinoma accounts for 8 to 9 percent of pediatric thyroid cancers. Medullary thyroid cancer (MTC) – Medullary carcinoma accounts for 4 percent …

English Journal

• Endocrine Pathology: SS08-2 A CASE OF DIFFUSE HYPERPLASIA OF THYROID GLAND WITH BIZARRE NUCLEI.

• Kim BH.
• Pathology.Pathology.2014 Oct;46 Suppl 2:S13. doi: 10.1097/01.PAT.0000454092.14116.db.
• A 44-year-old man submitted for enlarged thyroid gland. Fine needle aspiration cytology showed bizarre hyperchromatic nuclei and medullary carcinoma was suspected. Thyroidectomy was done and frozen slides revealed hyperplastic thyroid follicles with bizarre nuclei with perithyroidal extension. The f
• PMID 25188062

• Endocrine Pathology: SC08-1 GENETICS OF THYROID LESIONS UPDATED.

• Lam AK.
• Pathology.Pathology.2014 Oct;46 Suppl 2:S12. doi: 10.1097/01.PAT.0000454089.91244.a3.
• Advances in research into molecular biology of thyroid cancers have made exciting progress in the understanding of genetic pathways of the cancers. Despite the huge amount of genetic information of thyroid cancers, only a few genetic changes are of clinical value in the current settings. The best kn
• PMID 25188059

• Ectopic Cushing syndrome secondary to metastatic medullary thyroid cancer in a child with multiple endocrine neoplasia syndrome type 2B: clues to early diagnosis of the paraneoplastic syndromes.

• Singer K, Heiniger N, Thomas I, Worden FP, Menon RK, Chen M.
• Journal of pediatric endocrinology & metabolism : JPEM.J Pediatr Endocrinol Metab.2014 Sep 20;27(9-10):993-6. doi: 10.1515/jpem-2013-0456.
• Abstract We describe a 13-year-old male with multiple endocrine neoplasia syndrome type 2B with medullary thyroid carcinoma who was diagnosed with ectopic adrenocorticotropin-dependent Cushing syndrome. This report highlights the importance of monitoring for paraneoplastic syndrome in MEN and clues
• PMID 24859505

Japanese Journal

• 症例報告 甲状腺髄様癌の内深頸リンパ節再発に対し治癒切除が可能であった多発性内分泌腫瘍症2A型の1例

• 手塚 理恵,今井 常夫,安藤 孝人 [他]
• 日本内分泌・甲状腺外科学会雑誌 = Official journal of
• NAID 40020299391

• 症例報告 予防的甲状腺全摘術を行った遺伝性甲状腺髄様癌の一女児例

• 大石 一行,深田 修司,菱沼 昭 [他]
• 日本内分泌・甲状腺外科学会雑誌 = Official journal of
• NAID 40020098741

• Radiation-Associated Small Cell Neuroendocrine Carcinoma of the Thyroid: A Case Report with Molecular Analyses

• Mussazhanova Zhanna,Miura Shiro,Stanojevic Boban,Rougounovitch Tatiana,Saenko Vladimir,Shiraishi Toshio,Kurashige Tomomi,Shichijo Kazuko,Kaneko Kenichi,Takahashi Haruo,Ito Masahiro,Nakashima Masahiro
• Thyroid
• … Background: Neuroendocrine tumor (NET) of the thyroid other than medullary carcinoma is extremely rare. … We describe here a case of calcitonin-negative small cell neuroendocrine carcinoma (SCNEC), which occurred in a thyroid gland that had previously been irradiated at high dose (60Gy) for pharyngeal cancer, with molecular analyses for follicular cell origin. …
• NAID 120005438924

Related Links

• Thyroid cancer - medullary carcinoma: MedlinePlus Medical ...

Medullary carcinoma of the thyroid is cancer of the thyroid gland that starts in cells that release a hormone called calcitonin. These cells are called "C" cells. The thyroid gland is located inside the front of your lower neck.

• Medullary Thyroid Cancer Overview - The Third Most Common ...

Article discusses medullary thyroid cancer basics. Learn about common medullary thyroid cancer symptoms and treatments, such as thyroidectomy. ... Medullary thyroid cancer is the third most common type of thyroid cancer. This ...

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★リンクテーブル★

リンク元	「甲状腺髄様癌」
関連記事	「medullary」「medulla」「thyroid」

「甲状腺髄様癌」

　　[★]

英

medullary thyroid carcinoma MTC、medullary carcinoma of thyroid, thyroid medullary carcinoma

同

甲状腺C細胞癌、thyroid C-cell carcinoma

関

アミロイドーシス、甲状腺腫瘍、甲状腺癌

概念

• 甲状腺C細胞（傍濾胞細胞）由来のカルシトニン産生性の悪性腫瘍

疫学

• 甲状腺悪性腫瘍の5～10％？　甲状腺癌の1-2%(YN.D-41)
• 男女比はほぼ1：1　　男女比=1:2(YN.D-41)　
• 発症年齢は30歳代と50歳代がピーク

病型

• 家族性
• 散発性

病因

• RET遺伝子の点突然変異

• 常染色体優性遺伝疾患の多発性内分泌腫瘍症2A型，同2B型とおなじ

病理

• 腫瘍細胞の多様な像

• 類円形から多角形のさまざまな形態をとる腫瘍細胞が、シート状、胞巣状、島状あるいは管状、濾胞状、乳頭状の構造を呈する

• 間質のアミロイド沈着

病態

• 高カルシトニン血症：腫瘍細胞がカルシトニンを産生

進展様式

• リンパ行性が多く、血行性もある。

症状

• 甲状腺腫脹

検査

• 血液生化学

• カルシトニン：高値
• 腫瘍マーカー：CEA

• シンチグラム

• 131I-MIBGによるシンチ：腫瘍に集積

合併症

• 甲状腺髄様癌の1/3にMEN 2A(Sipple症候群)が、逆にMEN 2Aの60-95%に甲状腺髄様癌が存在する。

予後

• 10年生存率：60%

参考

• 1. [charged] Clinical manifestations and staging of medullary thyroid cancer - uptodate [1]
• 2. [charged] Treatment of medullary thyroid cancer - uptodate [2]
• 3. [charged] Chemotherapy and immunotherapy for medullary thyroid cancer - uptodate [3]

「medullary」

　　[★]

• adj.

• 延髄の、延髄性の、髄質の、髄質性の

関

bulbar、medulla、medulla oblongata

　 　 　

「medulla」

　　[★]

毛

• 毛髄質、毛髄

副腎

• 髄質

脳神経

• 延髄

　 　

「thyroid」

　　[★]

• n.

• 甲状腺

関

thyroid gland、thyroidal