WordNet

regulate housing in; of certain areas of towns (同)district
any of the regions of the surface of the Earth loosely divided according to latitude or longitude (同)geographical zone
(anatomy) any encircling or beltlike structure (同)zona
a locally circumscribed place characterized by some distinctive features
an area or region distinguished from adjacent parts by a distinctive feature or characteristic
the boundary line or the area immediately inside the boundary (同)border, perimeter
the amount of collateral a customer deposits with a broker when borrowing from the broker to buy securities (同)security deposit
an amount beyond the minimum necessary; "the margin of victory"
the blank space that surrounds the text on a page; "he jotted a note in the margin"
producing at a rate that barely covers production costs; "marginal industries"
dividing an area into zones or sections reserved for different purposes such as residence and business and manufacturing etc

PrepTutorEJDIC

(何らかの目的・特徴などによって他の地域と区別された)『地帯』,地域,地区(belt, area) / (気候によって地球を大別した)帯(たい) / 《米》(交通・郵便などの)同一料金区域;(郵便番号で分けた)郵便区 / (環状の)ベルト,輪,帯 / …‘を'地帯(地区)に分ける / (…の目的に)〈地域〉‘を'区画規制する《+名+as(for)+名》 / …‘を'帯で巻く,‘に'帯印をつける
『へり』,『縁』,端(edge) / (ページの)『余白』,欄外 / (可能の)限界,限度 / (空間・時間・経費・活動などの)余裕,余地 / 利ざや,マージン,販売利益
縁の,へりの / 限界の,ぎりぎりの,かろうじて要件を満たす / 《名詞の前にのみ用いて》余白に書いた,欄外の / かろうじて帳じりの合う,限界収益点の / 取るに足りない,小さな
(都市計画の)区画制,地区制

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/20 04:58:45」(JST)

wiki en

The marginal zone is the region at the interface between the non-lymphoid red pulp and the lymphoid white-pulp of the spleen. (Some sources consider it to be the part of red pulp which borders on the white pulp, while other sources consider it to be neither red pulp nor white pulp.)

A marginal zone also exists in lymph nodes.^[1]

Composition and markers

It is composed of cells derived primarily from the myeloid compartment of bone marrow differentiation. More recently, a population of neutrophils has been described to populate peripheral areas of the marginal zone.^[2] At least three distinct cellular markers can be used to identify cells of the marginal zone, MOMA-1, ERTR-9 and MARCO.

Function

The major role of marginal zone is to trap particulate antigen from the circulation and present the antigen to the lymphocytes of the spleen.

Experiments have shown that inert latex beads as well as live bacteria such as Escherichia coli and Listeria monocytogenes are trapped by the marginal zone. However, only immunogenic substances, i.e. bacteria, are trafficked to the T and B cell zones of the white-pulp and are efficiently presented to elicit an immune response.

Marginal Zone Circulation

The marginal zone (MZ) is a highly transited area that receives large amounts of blood from the general circulation. Remarkably, the splenic microvasculature shows striking differences in mice and humans. In humans, the spleen receives blood from the splenic artery, which branches into central arterioles and penicillary arterioles .^[3] Owing to the absence of a histologically defined marginal sinus, the blood flowing in penicillary arterioles directly drains into capillaries of the red pulp and perifollicular zone. The perifollicular zone is a well-defined area of decreased resistance that separates the MZ from the red pulp. Both the perifollicular zone and the red pulp consist of an open circulatory system of blood-filled spaces known as splenic cords, which have no defined endothelial delimitation and are in close contact with the venous sinusoidal vessels of the red pulp.^[4]

Lymphocytes

Marginal zone lymphocytes are a type of B cell (Marginal-zone B cell, abbreviated "MZ B cell") created there, capable of binding IgM-antigen complexes. They are notable for their ability to serve several different roles in the immune system. MZ B cells express polyreactive BCRs that bind to multiple microbial molecular patterns.^[5]

References

^ http://www.pathologyoutlines.com/lymphnodes.html^{[full citation needed]}
^ Puga, Irene; Cols, Montserrat; Barra, Carolina M; He, Bing; Cassis, Linda; Gentile, Maurizio; Chen, Kang; Cerutti, Andrea (December 2011). "B cell–helper neutrophils stimulate the diversification and production of immunoglobulin in the marginal zone of the spleen". Nature Immunology 13 (2): 170–80. doi:10.1038/ni.2194. PMID 22197976. Retrieved 30 April 2015.
^ Mebius, Reina E.; Kraal, Georg (August 2005). "Structure and function of the spleen". Nature Reviews Immunology 5 (1): 606–616. doi:10.1038/nri1669. PMID 16056254. Retrieved 30 April 2015.
^ Steiniger, Birte; Timphus,, Eva Maria; Barth, Peter J. (December 2006). "The splenic marginal zone in humans and rodents: an enigmatic compartment and its inhabitants". Histochemistry and Cell Biology 126 (6): 641–648. doi:10.1007/s00418-006-0210. PMID 16816939. Retrieved 30 April 2015.
^ Martin, Flavius; Kearney, John F. (May 2002). "Marginal-zone B cells". Nature Reviews Immunology 2 (5): 323–35. doi:10.1038/nri797. PMID 12033738. Retrieved 30 April 2015.

External links

Pillai S, Cariappa A, Moran ST (2005). "Marginal zone B cells". Annual Review of Immunology 23: 161–96. doi:10.1146/annurev.immunol.23.021704.115728. PMID 15771569.
Ferguson AR, Corley RB (2005). "Accumulation of marginal zone B cells and accelerated loss of follicular dendritic cells in NF-κB p50-deficient mice". BMC Immunology 6: 8. doi:10.1186/1471-2172-6-8. PMC 1087843. PMID 15836790.
Marginal zone lymphomas
Song H, Cerny J (December 2003). "Functional heterogeneity of marginal zone B cells revealed by their ability to generate both early antibody-forming cells and germinal centers with hypermutation and memory in response to a T-dependent antigen". The Journal of Experimental Medicine 198 (12): 1923–35. doi:10.1084/jem.20031498. PMC 2194154. PMID 14662910.
Kraal G (1992). "Cells in the marginal zone of the spleen". International Review of Cytology 132: 31–74. doi:10.1016/S0074-7696(08)62453-5. PMID 1555921.
Kumararatne DS, MacLennan IC (November 1981). "Cells of the marginal zone of the spleen are lymphocytes derived from recirculating precursors". European Journal of Immunology 11 (11): 865–9. doi:10.1002/eji.1830111104. PMID 6976895.

UpToDate Contents

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1. 辺縁帯（MALT）リンパ腫の治療 treatment of marginal zone malt lymphoma
2. 節外（MALT）および節性濾胞辺縁帯リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of extranodal malt and nodal marginal zone lymphomas
3. 原発性皮膚辺縁帯リンパ腫 primary cutaneous marginal zone lymphoma
4. 脾辺縁帯リンパ腫の臨床症状、病理学的特徴、および診断 clinical manifestations pathologic features and diagnosis of splenic marginal zone lymphoma
5. 消化管リンパ腫のマネージメント management of gastrointestinal lymphomas

English Journal

Disorganization of the splenic microanatomy in ageing mice.

Aw D1, Hilliard L1, Nishikawa Y1, Cadman ET1, Lawrence RA1, Palmer DB1.
Immunology.Immunology.2016 May;148(1):92-101. doi: 10.1111/imm.12590. Epub 2016 Mar 17.
The precise mechanisms responsible for immunosenescence still remain to be determined, however, considering the evidence that disruption of the organization of primary and secondary lymphoid organs results in immunodeficiency, we propose that this could be involved in the decline of immune responses
PMID 26840375

Rare Pediatric Non-Hodgkin Lymphomas: A Report From Children's Oncology Group Study ANHL 04B1.

O'Suoji C1, Welch JJ2, Perkins SL3, Smith LM4, Weitzman S5, Simko SJ6, Galardy PJ7, Bollard CM8, Gross TG9, Termuhlen AM10.
Pediatric blood & cancer.Pediatr Blood Cancer.2016 May;63(5):794-800. doi: 10.1002/pbc.25881. Epub 2016 Jan 5.
BACKGROUND: Non-Hodgkin lymphoma (NHL) is a relatively common malignancy in pediatric patients; however, a small subgroup have unusual lymphoma subtypes for the pediatric population.PROCEDURE: The Children's Oncology Group Rare and Cutaneous NHL registry's (protocol ANHL 04B1) main objectives were t
PMID 26728447

Genetically predicted longer telomere length is associated with increased risk of B-cell lymphoma subtypes.

Machiela MJ, Lan Q, Slager SL, Vermeulen RC, Teras LR, Camp NJ, Cerhan JR, Spinelli JJ, Wang SS, Nieters A, Vijai J, Yeager M, Wang Z, Ghesquières H, McKay J, Conde L, de Bakker PI, Cox DG, Burdett L, Monnereau A, Flowers CR, De Roos AJ, Brooks-Wilson AR, Giles GG, Melbye M, Gu J, Jackson RD, Kane E, Purdue MP, Vajdic CM, Albanes D, Kelly RS, Zucca M, Bertrand KA, Zeleniuch-Jacquotte A, Lawrence C, Hutchinson A, Zhi D, Habermann TM, Link BK, Novak AJ, Dogan A, Asmann YW, Liebow M, Thompson CA, Ansell SM, Witzig TE, Tilly H, Haioun C, Molina TJ, Hjalgrim H, Glimelius B, Adami HO, Roos G, Bracci PM, Riby J, Smith MT, Holly EA, Cozen W, Hartge P, Morton LM, Severson RK, Tinker LF, North KE, Becker N, Benavente Y, Boffetta P, Brennan P, Foretova L, Maynadie M, Staines A, Lightfoot T, Crouch S, Smith A, Roman E, Diver WR, Offit K, Zelenetz A, Klein RJ, Villano DJ, Zheng T, Zhang Y, Holford TR, Turner J, Southey MC, Clavel J, Virtamo J, Weinstein S, Riboli E, Vineis P, Kaaks R, Boeing H, Tjønneland A, Angelucci E, Di Lollo S, Rais M, De Vivo I, Giovannucci E, Kraft P, Huang J, Ma B, Ye Y, Chiu BC, Liang L, Park JH, Chung CC, Weisenburger DD, Fraumeni JF Jr, Salles G, Glenn M, Cannon-Albright L, Curtin K, Wu X, Smedby KE, de Sanjose S, Skibola CF, Berndt SI, Birmann BM, Chanock SJ, Rothman N.
Human molecular genetics.Hum Mol Genet.2016 Apr 15;25(8):1663-76. doi: 10.1093/hmg/ddw027. Epub 2016 Feb 9.
Evidence from a small number of studies suggests that longer telomere length measured in peripheral leukocytes is associated with an increased risk of non-Hodgkin lymphoma (NHL). However, these studies may be biased by reverse causation, confounded by unmeasured environmental exposures and might mis
PMID 27008888

Japanese Journal

第54次日本南極地域観測隊東京海洋大学研究練習船「海鷹丸」（KARE16 ; UM-12-08）活動報告

南極資料 = Antarctic Record 60, 49-64, 2016-07
NAID 120005822168

Marginal zone B cells exacerbate endotoxic shock via interleukin-6 secretion induced by Fcα/μR-coupled TLR4 signalling

Nature communications 7, 11498, 2016-05
NAID 120005767132

新潟県新発田市~岩船郡関川村に分布する中部中新統七谷層・寺泊層黒色泥岩の炭化水素ポテンシャル (赤坂正秀教授退職記念特集号)

島根大学地球資源環境学研究報告 = Geocience reports of Shimane University (34), 59-68, 2016-03
NAID 120005749762

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リンク元	「辺縁帯」「帯域」
拡張検索	「marginal zone B-cell lymphoma」「extranodal marginal zone B-cell lymphoma of MALT」「extranodal marginal zone B-cell lymphoma of mucosa associated lymphoid tissue」「splenic marginal zone B-cell lymphoma」
関連記事	「margin」「zone」「marginal」