- 関
- voltage dependence、voltage-dependent
WordNet
- the rate at which energy is drawn from a source that produces a flow of electricity in a circuit; expressed in volts (同)electromotive_force, emf
PrepTutorEJDIC
- 電圧,電圧量,ボルト数
- 属国,保護領
UpToDate Contents
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English Journal
- Glutamatergic Dysfunctioning in Alzheimer's Disease and Related Therapeutic Targets.
- Zádori D1, Veres G1, Szalárdy L1, Klivényi P1, Toldi J2, Vécsei L3.Author information 1Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary.2Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary MTA-SZTE Neuroscience Research Group, Szeged, Hungary.3Department of Neurology, Faculty of Medicine, Albert Szent-Györgyi Clinical Center, University of Szeged, Szeged, Hungary MTA-SZTE Neuroscience Research Group, Szeged, Hungary.AbstractThe impairment of glutamatergic neurotransmission plays an important role in the development of Alzheimer's disease (AD). The pathological process, which involves the production of amyloid-β peptides and hyperphosphorylated tau proteins, spreads over well-delineated neuroanatomical circuits. The gradual deterioration of proper synaptic functioning (via GluN2A-containing N-methyl-D-aspartate receptors, NMDARs) and the development of excitotoxicity (via GluN2B-containing NMDARs) in these structures both accompany the disease pathogenesis. Although one of the most important therapeutic targets would be glutamate excitotoxicity, the application of conventional anti-glutamatergic agents could result in further deterioration of synaptic transmission and intolerable side-effects. With regard to NMDAR antagonists with tolerable side-effects, ion channel blockers with low affinity, glycine site agents, and specific antagonists of polyamine site and GluN2B subunit may come into play. However, in the mirror of experimental data, only the application of ion channel blockers with pronounced voltage dependency, low affinity, and rapid unblocking kinetics (e.g., memantine) and specific antagonists of the GluN2B subunit (e.g., ifenprodil and certain kynurenic acid amides) resulted in desirable symptom amelioration. Therefore we propose that these kinds of chemical agents may have therapeutic potential for present and future drug development.
- Journal of Alzheimer's disease : JAD.J Alzheimers Dis.2014 Mar 26. [Epub ahead of print]
- The impairment of glutamatergic neurotransmission plays an important role in the development of Alzheimer's disease (AD). The pathological process, which involves the production of amyloid-β peptides and hyperphosphorylated tau proteins, spreads over well-delineated neuroanatomical circuits. The gr
- PMID 24670398
- Clinical spectrum of epileptic spasms in children.
- Lee YJ1, Berg AT2, Nordli DR Jr2.Author information 1Department of Pediatrics, Pusan National University Children's Hospital, Pusan National University, Yangsan, South Korea; Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, South Korea. Electronic address: jinnyeye@hanmail.net.2Epilepsy Center, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.AbstractPurpose: To compare etiologic, semiologic, and electrographic features of epileptic spasms (ES) in children with West syndrome (WS) vs. in children with other epilepsy syndromes and nonsyndromic epilepsies. Methods: The 24h-video/EEG recordings of consecutive children with ES were reviewed for etiology, ictal semiology, and interictal and ictal EEG features. We created three objectively-defined groups for interictal EEG: (A) background voltage >300μV with multiple independent spike foci (MISF) and disorganization consistent with hypsarhythmia; (B) voltage between 200 and 300μV with MISF and moderate disorganization, similar but not identical to hypsarhythmia; (C) voltage <200μV±MISF , not consistent with hypsarhythmia. Results: We identified 161 children (group A, 70; group B, 32; group C, 59). The greatest difference between the groups A, B, and C, respectively was in age (in months) both at onset (6.4±4.4, 15.3±22.1 and 31.6±38.1, p<0.0001) and at EEG (10.8±6.9, 22.9±26.2 and 45.6±42.1, p<0.0001). The groups also showed some differences in the frequency of preceding or admixed seizures, and in seizure semiology. By contrast, there were no significant differences in the underlying causes or in patterns of ictal discharges between the groups. Conclusion: ES clearly exist outside of the confines of WS with some phenomenological variations. The causes and ictal patterns, however, are remarkably similar among all patients with ES. The subtle difference in seizure semiology may reflect maturational changes. These findings support the concept of a spectrum of ES with a degree of age-dependency in its manifestations rather than entirely different clinical entities.
- Brain & development.Brain Dev.2014 Mar 22. pii: S0387-7604(14)00060-6. doi: 10.1016/j.braindev.2014.02.009. [Epub ahead of print]
- Purpose: To compare etiologic, semiologic, and electrographic features of epileptic spasms (ES) in children with West syndrome (WS) vs. in children with other epilepsy syndromes and nonsyndromic epilepsies. Methods: The 24h-video/EEG recordings of consecutive children with ES were reviewed for etiol
- PMID 24667104
- Voltage-dependency of slow wave frequency in the guinea-pig prostate.
- Shigemasa Y1, Lam M1, Mitsui R1, Hashitani H2.Author information 1Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-ku, Nagoya, 467-8601, Japan.2Department of Cell Physiology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-ku, Nagoya, 467-8601, Japan. Electronic address: hasitani@med.nagoya-cu.ac.jp.AbstractPURPOSE: Spontaneous phasic contractions of the guinea-pig prostate stroma result from the generation of slow waves that appear to primarily rely on spontaneous Ca2+ release from the endo/sarcoplasmic reticulum and subsequent opening of Ca2+-activated chloride channels. This study investigated the voltage-dependent mechanisms in regulating slow wave frequency.
- The Journal of urology.J Urol.2014 Mar 15. pii: S0022-5347(14)02951-6. doi: 10.1016/j.juro.2014.03.034. [Epub ahead of print]
- PURPOSE: Spontaneous phasic contractions of the guinea-pig prostate stroma result from the generation of slow waves that appear to primarily rely on spontaneous Ca2+ release from the endo/sarcoplasmic reticulum and subsequent opening of Ca2+-activated chloride channels. This study investigated the v
- PMID 24641914
Japanese Journal
- Analysis of read disturbance mechanism in retention of sub-20 nm NAND flash memory
- Kang Duckseoung,Lee Kyunghwan,Kwon Sangjin,Kim Shinhyung,Hwang Yuchul,Shin Hyungcheol
- Jpn. J. Appl. Phys. 54(4S), 04DD03, 2015-02-24
- … We observed an increase of V<inf>th</inf>by read disturbance mechanism at programmed threshold voltage state (PV1) and erase state (ERS) states in retention characteristics of sub-20 nm NAND flash main-chip. … We also confirmed that the charge gain behavior by read disturbance has dependency on the number of read and cycling operations. …
- NAID 150000110351
- Ion-Selective Oscillatory Wetting under a DC Electric Field
- NAGATA Shunya,YAMAMOTO Daigo,SHIOI Akihisa
- JOURNAL OF CHEMICAL ENGINEERING OF JAPAN 48(1), 80-86, 2015
- … The ion-dependency of oscillatory wetting under a DC voltage, which had been reported previously, was studied in detail. … The contact line of the oil/water interface and the glass surface exhibited a successive pulsation under a DC voltage. … The mechanism for the ion dependency was examined in detail. …
- NAID 130004862038
- Simulation Study of Short-Channel Effect in MOSFET with Two-Dimensional Materials Channel
- HARADA Naoki,SATO Shintaro,YOKOYAMA Naoki
- IEICE Transactions on Electronics E98.C(3), 283-286, 2015
- … We derived the surface potential roll-up, drain-induced barrier lowering (DIBL), threshold voltage, and subthreshold swing (SS) as indexes of the SCE and analyzed their dependency on the channel thickness (number of atomic layers) and channel length. … MOSFET was determined from the threshold voltage roll-off to be 7.6 nm. …
- NAID 130004841714
★リンクテーブル★
[★]
- 英
- voltage dependence、voltage dependency、voltage-dependent
- 関
- 電位依存的、膜電位依存性、電位依存
[★]
- 関
- voltage dependence、voltage dependency
[★]
- 関
- voltage dependency、voltage-dependent
[★]
- 関
- electric potential、electrical potential、potential
[★]
- 関
- dependent