WordNet

a deficiency of red blood cells (同)anaemia
a lack of vitality (同)anaemia
genus of terrestrial or lithophytic ferns having pinnatifid fronds; chiefly of tropical America (同)genus Anemia

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1. 貧血を有する成人患者に対するアプローチ approach to the adult patient with anemia
2. 貧血を有する小児に対するアプローチ approach to the child with anemia
3. 小児における溶血性貧血の概要 overview of hemolytic anemias in children
4. 赤血球産生低下による貧血 anemias due to decreased red cell production
5. Sideroblastic anemias: Diagnosis and management

English Journal

Sideroblastic Anemia: Diagnosis and Management.

Bottomley SS1, Fleming MD2.
Hematology/oncology clinics of North America.Hematol Oncol Clin North Am.2014 Aug;28(4):653-670. doi: 10.1016/j.hoc.2014.04.008. Epub 2014 Jun 2.
Sideroblastic anemias (SAs) may be acquired or congenital and share the features of disrupted utilization of iron in the erythroblast, ineffective erythropoiesis, and variable systemic iron overload. Congenital forms can have associated syndromic features or be nonsyndromic, and many of them have mu
PMID 25064706

Percutaneous excretion of iron and ferritin (through Al-hijamah) as a novel treatment for iron overload in beta-thalassemia major, hemochromatosis and sideroblastic anemia.

El Sayed SM1, Abou-Taleb A2, Mahmoud HS3, Baghdadi H4, Maria RA5, Ahmed NS6, Nabo MM7.
Medical hypotheses.Med Hypotheses.2014 Aug;83(2):238-46. doi: 10.1016/j.mehy.2014.04.001. Epub 2014 Apr 8.
Iron overload is a big challenge when treating thalassemia (TM), hemochromatosis and sideroblastic anemia. It persists even after cure of TM with bone marrow transplantation. Iron overload results from increased iron absorption and repeated blood transfusions causing increased iron in plasma and int
PMID 24857772

Mitochondrial transporters of the SLC25 family and associated diseases: a review.

Palmieri F.
Journal of inherited metabolic disease.J Inherit Metab Dis.2014 Jul;37(4):565-75. doi: 10.1007/s10545-014-9708-5. Epub 2014 May 6.
To date, 14 inherited diseases (including phenotypes) associated to mitochondrial transporters of the SLC25 family have been well characterized biochemically and genetically. They are rare metabolic disorders caused by mutations in the SLC25 nuclear genes that encode mitochondrial carriers, a superf
PMID 24797559

Japanese Journal

Idiopathic refractory sideroachrestic anemia progressing to acute mixed lymphoblasticmyelomonocytic leukemia

HEHLMANN R
Blut. 46, 11-21, 1983
NAID 30013239396

農繁期における農夫症の血液学的研究

吉田伍郎
日本農村医学会雑誌 20(1), 22-28, 1971
… was over two folds of that of the 80 non F.S.cases, without sex discrimination.<BR>2) As regards the mean value of blood sugar, blood sugar level in the female group was low.<BR>3) From the red blood cell indices (Wintrobe) anemia was classified as: myelophthic anemia (normochromic normocytic) of males;chromic simple anemia due to infection hypoendocrinism (hypochromic normocytic);anemia due to infection or deficiency of Vitamin B6 (normochromic …
NAID 130004383708

鉄非利用性低色素性貧血(Sideroachrestic hypochromic anemia)について

小宮正文
治療 47(4), 489-495, 1965-04
NAID 40018053351

「鉄芽球性貧血」

　　[★]

英: sideroblastic anemia SA
ラ: anemia sideroblastica
同: 鉄不応性貧血 sideroachrestic anemia
関: 環状鉄芽球、貧血、続発性鉄芽球性貧血

概念

ヘム合成障害による無効造血によって貧血を来す症候群

病因

原発性

後天性
先天性

続発性

薬剤性：INH、サイクロセリン、アザチオプリン、クロラムフェニコール
症候性：関節リウマチ、悪性腫瘍、骨髄異形成症 MDS(骨髄線維症)、白血病、多発性骨髄腫、サラセミア
中毒性：アルコール中毒、鉛中毒

ピリドキシン反応性：ビタミンB6投与により改善(ピリドキシン反応性貧血)

検査

(根拠無き解釈)骨髄では鉄が赤芽球に取り込まれてはアポトーシスに至り無効造血が続いており、鉄の需要はない。このため、末梢血中の鉄は使用されないため増加、また網内系の貯蔵鉄も使用されないまま蓄積するので血清フェリチンが増加する。総鉄結合能はトランスフェリンの全体量は変化せず不変。骨髄ではなんとか赤血球を作ろうと、過形成となっており、赤芽球が著明にみられる。