WordNet

a complex consisting of an organic base in association with hydrogen chloride

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/20 16:53:07」(JST)

wiki en

Nicardipine hydrochloride (Cardene) is a medication used to treat high blood pressure and angina. It belongs to the class of calcium channel blockers.

Nicardipine is a dihydropyridine calcium-channel blocking agent used for the treatment of vascular disorders such as chronic stable angina, hypertension, and Raynaud's phenomenon. It is available in oral and intravenous formulations. Its mechanism of action and clinical effects closely resemble those of nifedipine and the other dihydropyridines (amlodipine, felodipine), except that nicardipine is more selective for cerebral and coronary blood vessels. Furthermore, nicardipine does not intrinsically decrease myocardial contractility and may be useful in the management of congestive heart failure. Nicardipine also has a longer half-life than nifedipine. Nicardipine was approved by the FDA in December 1988. The patent for both Cardene and Cardene SR expired in October 1995.

It has been used in percutaneous coronary intervention.^[1] Nicardipine is also an option for lowering of blood pressure in stroke patients who require blood pressure lowering prior to administration of Alteplase when blood pressure is >185/110. Also may be used during rtPA therapy when blood pressure is >230/120.

Nicardipine must be used with caution in patients with renal failure because of possible kidney shutdown.

Nicardipine inhibits the transmembrane influx of calcium ions into cardiac muscle and smooth muscle without changing serum calcium concentrations. The contractile processes of cardiac muscle and vascular smooth muscle are dependent upon the movement of extracellular calcium ions into these cells through specific ion channels. The effects of nicardipine are more selective to vascular smooth muscle than cardiac muscle. In animal models, nicardipine produced relaxation of coronary vascular smooth muscle at drug levels which cause little or no negative inotropic effect.

References[edit]

^ Huang RI, Patel P, Walinsky P, et al. (November 2006). "Efficacy of intracoronary nicardipine in the treatment of no-reflow during percutaneous coronary intervention". Catheter Cardiovasc Interv 68 (5): 671–6. doi:10.1002/ccd.20885. PMID 17034064.

This drug article relating to the cardiovascular system is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 頸動脈内膜剥離術および頸動脈ステント留置術の麻酔 anesthesia for carotid endarterectomy and carotid stenting
2. 腹部大動脈瘤ステントグラフト留置術に対する麻酔 anesthesia for endovascular aortic repair
3. 高血圧緊急症の治療に用いる薬物 drugs used for the treatment of hypertensive emergencies
4. 成人における高血圧緊急症の評価および治療 evaluation and treatment of hypertensive emergencies in adults
5. 動脈瘤性くも膜下出血の治療 treatment of aneurysmal subarachnoid hemorrhage

English Journal

Cholesterol reduces the sensitivity to platinum-based chemotherapy via upregulating ABCG2 in lung adenocarcinoma.

Wu Y1, Si R2, Tang H1, He Z1, Zhu H1, Wang L1, Fan Y3, Xia S4, He Z5, Wang Q6.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2015 Jan 17. pii: S0006-291X(15)00057-1. doi: 10.1016/j.bbrc.2015.01.035. [Epub ahead of print]
Inoperable lung adenocarcinoma is currently treated with platinum-based chemotherapy. However, the effectiveness of these chemotherapeutic agents is not the same for all patients. Patients either show quick chemoresistance (QCR) or delayed chemoresistance (DCR), which are defined by 87 and 242 days
PMID 25603057

Intrathecal application of the nimodipine slow-release microparticle system eg-1962 for prevention of delayed cerebral ischemia and improvement of outcome after aneurysmal subarachnoid hemorrhage.

Etminan N1, Macdonald RL, Davis C, Burton K, Steiger HJ, Hänggi D.
Acta neurochirurgica. Supplement.Acta Neurochir Suppl.2015;120:281-6. doi: 10.1007/978-3-319-04981-6_47.
The effective reduction of delayed cerebral ischemia (DCI), a main contributor for poor outcome following aneurysmal subarachnoid hemorrhage (SAH), remains challenging. Previous clinical trials on systemic pharmaceutical treatment of SAH mostly failed to improve outcome, probably because of insensit
PMID 25366637

Effects of diltiazem on sympathetic activity in patients with aneurysmal subarachnoid hemorrhage.

Ogura T1, Takeda R, Ooigawa H, Nakajima H, Kurita H.
Acta neurochirurgica. Supplement.Acta Neurochir Suppl.2015;120:47-50. doi: 10.1007/978-3-319-04981-6_8.
This study evaluated the effect of diltiazem, a calcium antagonist, on sympathetic activity in patients with aneurysmal subarachnoid hemorrhage (SAH) during the hyperacute stage. Of patients with aneurysmal SAH who underwent aneurysm repair between August 2008 and June 2011, 119 consecutive patients
PMID 25366598

Japanese Journal

A Novel Rapid Quantitative Analysis of Drug Migration on Tablets Using Laser Induced Breakdown Spectroscopy

Yokoyama Makoto,Tourigny Martine,Moroshima Kenji [他],Suzuki Junsuke,Sakai Miyako,Iwamoto Kiyoshi,Takeuchi Hirofumi
Chemical and Pharmaceutical Bulletin 58(11), 1521-1524, 2010
… To evaluate drug migration, model tablets containing nicardipine hydrochloride as active pharmaceutical ingredient (API) were prepared by a conventional wet granulation method. …
NAID 130000405669

全身麻酔中に塩酸ニカルジピン投与が原因と思われる低酸素血症をきたした肥満患者の1例

佐藤健一,久慈昭慶,佐藤裕,坂本望,鍋島謙一,西健,鹿島悠子,四戸豊,佐藤雅仁,城茂治
日本歯科麻酔学会雑誌 = JOURNAL OF JAPANESE DENTAL SOCIETY OF ANESTHESIOLOGY 35(3), 396-397, 2007-07-15
NAID 10019533019

INDUCTION OF HEPATIC CYTOCHROME P450 ISOFORMS BY NICARDIPINE AT THERAPEUTIC DOSES IN SPONTANEOUSLY HYPERTENSIVE RATS

Miyajima Shoji,Nemoto Kiyomitsu,Sekimoto Masashi [他],KINAE Yusuke,KASAHARA Toshihiko,SOUMA Shinji,DEGAWA Masakuni
Journal of toxicological sciences 32(1), 79-90, 2007-02-16
… Nicardipine hydrochloride (Nic), a calcium channel antagonist, is used for the treatment of hypertension. …
NAID 110006204881

「ニカルジピン」

Nicardipine
Systematic (IUPAC) name
	2-[benzyl(methyl)amino]ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Clinical data
Trade names	Cardene
AHFS/Drugs.com	monograph
MedlinePlus	a695032
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral, intravenous
Pharmacokinetic data
Protein binding	>95%
Half-life	8.6 hours
Identifiers
CAS number	55985-32-5
ATC code	C08CA04
PubChem	CID 4474
IUPHAR ligand	2559
DrugBank	DB00622
ChemSpider	4319
UNII	CZ5312222S
KEGG	D08270
ChEMBL	CHEMBL1484
Chemical data
Formula	C26H29N3O6
Mol. mass	479.525 g/mol
	SMILES O=C(OCCN(Cc1ccccc1)C)\C2=C(\N/C(=C(/C(=O)OC)C2c3cccc([N+]([O-])=O)c3)C)C;
	InChI InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3 ; Key:ZBBHBTPTTSWHBA-UHFFFAOYSA-N ;
Physical data
Melt. point	136-138 °C (-80 °F)
(what is this?) (verify);