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1. 癌治療に用いる分子標的薬やそれ以外の生物学的製剤により皮膚に生じる副作用cutaneous side effects of molecularly targeted therapy and other biologic agents used for cancer therapy [show details]
…imatinib, several cutaneous effects are described In a total of 911 patients reported in phase I and II studies of dasatinib, cutaneous eruptions were reported in 35 percent . Reactions included localized …
2. 従来の抗癌剤に伴う皮膚障害cutaneous side effects of conventional chemotherapy agents [show details]
…knowledgeable of the most commonly reported cutaneous reaction patterns for the drugs the patient is receiving. The clinician must also be familiar with the cutaneous manifestations of certain cancers, as well …
3. 成人におけるライム病の臨床症状clinical manifestations of lyme disease in adults [show details]
… disease can generally be divided into three phases: early localized, early disseminated, and late disease However,… borrelial lymphocytoma is a rare cutaneous manifestation of Lyme disease that usually occurs during the early phase of infection .… While early erythema at the tick bite site is common due to a reaction to antigens in the tick saliva, this early allergic reaction must be differentiated from EM,…
4. 梅毒：治療とモニタリングsyphilis treatment and monitoring [show details]
…manifestations of late syphilis, and/or treatment failure. Patients with a history of an immediate-type hypersensitivity reaction require desensitization. For patients with a history of a delayed-type reaction,… the initial phase of infection, the organism disseminates widely, setting the stage for subsequent manifestations. If untreated, syphilis can have a number of significant late adverse outcomes,… Cutaneous gummas usually heal rapidly after penicillin therapy with little scarring.…
5. ライム病の治療treatment of lyme disease [show details]
… disease can generally be divided into three phases: early localized, early disseminated, and late disease However,… acrodermatitis chronica atrophicans is a cutaneous manifestation of late Lyme disease that may appear years following primary infection.… Although the majority of drug reactions were not severe, four serious allergic reactions occurred when patients received ceftriaxone.…

English Journal

A novel role for neutrophils in IgE-mediated allergy: Evidence for antigen presentation in late-phase reactions.

Polak D, Hafner C, Briza P, Kitzmüller C, Elbe-Bürger A, Samadi N, Gschwandtner M, Pfützner W, Zlabinger GJ, Jahn-Schmid B, Bohle B.
The Journal of allergy and clinical immunology. 2019 Mar;143(3)1143-1152.e4.
Neutrophils and allergen-specific T cells accumulate in patients with allergic late-phase reactions (LPRs). Their presence is associated with severe inflammation. Cytokines, such as GM-CSF, IFN-γ, and IL-3, which are typically found in patients with allergic LPRs, have been proposed to convert neut
PMID 29920351

A foot tumour as late cutaneous Lyme borreliosis: a new entity?

Bauvin O, Schmutz JL, De Martino S, Busato T, Cribier B, Barbaud A, Wahl D, Bursztejn AC.
The British journal of dermatology. 2017 Oct;177(4)1127-1130.
Acrodermatitis chronica atrophicans (ACA) is the late cutaneous form of Lyme borreliosis. The early inflammatory phase manifests with a bluish-red discoloration and doughy swelling of the skin. The atrophic phase represents a late-phase process with red discoloration, and a thin and wrinkled appeara
PMID 28477365

Passive blood anaphylaxis: subcutaneous immunoglobulins are a cause of ongoing passive anaphylactic reaction.

Zdziarski P, Gamian A, Majda J, Korzeniowska-Kowal A.
Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology. 2017 ;13()41.
Allergic, especially anaphylactic, reactions during immunoglobulin replacement therapy are rare, but their pathophysiology and classification remain ambiguous. Recent findings show positive results of skin tests with commercially available immunoglobulins, but target antigens and responsible compoun
PMID 28924447

Japanese Journal

Histamine Release Inhibitory Activity of Piper nigrum Leaf

Hirata Noriko,Naruto Shunsuke,Inaba Kazunori [他],ITOH Kimihisa,TOKUNAGA Masashi,IINUMA Munekazu,MATSUDA Hideaki
Biological & pharmaceutical bulletin 31(10), 1973-1976, 2008-10-01
… leaf (PN-ext, 50, 200 and 500 mg/kg) showed a potent dose-dependent inhibition of dinitrofluorobenzene (DNFB)-induced cutaneous reaction at 1 h [immediate phase response (IPR)] after and 24 h [late phase response (LPR)] after DNFB challenge in mice which were passively sensitized with anti-dinitrophenyl (DNP) IgE antibody. …
NAID 110006936345

Phase-dependent roles of E-selectin during chronic contact hypersensitivity responses.

Fujita Tomoyuki,Fujimoto Manabu,Matsushita Takashi,Shimada Yuka,Hasegawa Minoru,Kuwano Yoshihiro,Ogawa Fumihide,Takehara Kazuhiko,Sato Shinichi
The American journal of pathology 170(5), 1649-1658, 2007-05-01
金沢大学大学院医学系研究科血管分子科学
NAID 120001138017

麻黄配剤漢方方剤の Dinitrofluorobenzene 誘発3相性皮膚反応抑制作用

久保道徳,西村幸容,松田秀秋,中尾紀久世,田原英一,新谷卓弘
和漢医薬学雑誌 = Journal of traditional medicines 21(3), 147-153, 2004-06-20
… Anti-allergic effects of 9 Kampo medicines containing Ephedrae Herba on dinitrofluorobenzene (DNFB)-induced triphasic skin reaction were investigated. … ln the animal model, it was found that Kakkon-To, Sho-Sei-Ryu-To, Shimpi-To and Mao-Bushi-Saishin-To inhibited the ear swelling of IPR (immediate phase response), LPR (late phase response) and vLPR (very late phase response). …
NAID 110001846635