関: killer cell immunoglobulin-like receptor、KIR receptor

WordNet

overwhelm with hilarity, pleasure, or admiration; "The comedian was so funny, he was killing me!"
cause to cease operating; "kill the engine"
destroy a vitally essential quality of or in; "Eating artichokes kills the taste of all other foods"
tire out completely; "The daily stress of her work is killing her"
the destruction of an enemy plane or ship or tank or missile; "the pilot reported two kills during the mission"
mark for deletion, rub off, or erase; "kill these lines in the Presidents speech" (同)obliterate, wipe_out
thwart the passage of; "kill a motion"; "he shot down the students proposal" (同)shoot down, defeat, vote down, vote out
be fatal; "cigarettes kill"; "drunken driving kills"
be the source of great pain for; "These new shoes are killing me!"
cause the death of, without intention; "She was killed in the collision of three cars"
cause to die; put to death, usually intentionally or knowingly; "This man killed several people when he tried to rob a bank"; "The farmer killed a pig for the holidays"
deprive of life; "AIDS has killed thousands in Africa"
hit with great force; "He killed the ball"
hit with so much force as to make a return impossible, in racket games; "She killed the ball"
a substance that retards or stops an activity
someone who causes the death of a person or animal (同)slayer
a difficulty that is hard to deal with; "that exam was a real killer"
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
restrictive of action; "a repressive regime"; "an overly strict and inhibiting discipline" (同)repressive, repressing

PrepTutorEJDIC

〈人・動物〉‘を'『殺す』,死亡させる / 〈植物〉‘を'枯らす / …‘を'だめにする,失わせる / 《話》…‘を'ひどく痛ませる(疲れさせる,不快にさせる) / 〈時間〉‘を'つぶす / 〈記事など〉‘を'没にする,握りつぶす / 人殺しをする / 殺すこと;(特に狩猟の)獲物をしとめること / (猟の)獲物
抑制する人(物) / 化学反応抑制剤
殺人者;屠殺(とさつ)者;殺し屋
=sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/23 07:38:05」(JST)

wiki en

Killer-cell immunoglobulin-like receptors (KIRs), are a family of cell surface proteins found on important cells of the immune system called natural killer (NK) cells. They regulate the killing function of these cells by interacting with MHC class I molecules, which are expressed on all cell types. This interaction allows them to detect virally infected cells or tumor cells that have a characteristic low level of Class I MHC on their surface. Most KIRs are inhibitory, meaning that their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the ability to activate cells.^[1] KIR molecules are highly polymorphic, meaning their gene sequences differ greatly between individuals, so that different individuals possess different arrays/repertoires of KIR genes.^[2]

Genes

two domains, long cytoplasmic tail: KIR2DL1, KIR2DL2, KIR2DL3, KIR2DL4, KIR2DL5A, KIR2DL5B,
two domains, short cytoplasmic tail: KIR2DS1, KIR2DS2, KIR2DS3, KIR2DS4, KIR2DS5
three domains, long cytoplasmic tail: KIR3DL1, KIR3DL2, KIR3DL3
three domains, short cytoplasmic tail: KIR3DS1

References

^ Vilches C, Parham P (2002). "KIR: diverse, rapidly evolving receptors of innate and adaptive immunity". Annu Rev Immunol 20: 217–51. doi:10.1146/annurev.immunol.20.092501.134942. PMID 11861603.
^ Uhrberg M (2005). "The KIR gene family: life in the fast lane of evolution". Eur J Immunol 35 (1): 10–5. doi:10.1002/eji.200425743. PMID 15580655.

External links

http://www.KIRtyping.info
The KIR Gene Cluster, NIH Bookshelf, PDF
killer cell immunoglobulin-like receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

This article about a biochemical receptor is a stub. You can help Wikipedia by expanding it.

This immunology article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 造血細胞移植後の移植片対腫瘍効果の生物学 biology of the graft versus tumor effect following hematopoietic cell transplantation
2. 新生児の免疫 immunity of the newborn
3. 造血細胞移植後の再発の予防および治療のための免疫療法 immunotherapy for the prevention and treatment of relapse following hematopoietic cell transplantation

English Journal

Influence of Differently Licensed KIR2DL1-Positive Natural Killer Cells in Transplant Recipients with Acute Leukemia: A Japanese National Registry Study.

Arima N1, Nakamura F2, Yabe T3, Tanaka J4, Fuji S5, Ohashi K6, Fukuda T5, Miyamura K7, Iwato K8, Eto T9, Mori T10, Kobayashi N11, Hoshino T12, Kato C13, Kanamori H14, Nakamae H15, Atsuta Y16, Morishima Y17, Kanda Y18.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.Biol Blood Marrow Transplant.2016 Mar;22(3):423-31. doi: 10.1016/j.bbmt.2015.09.029. Epub 2015 Oct 9.
Licensing by self MHC class I ligands is required for proper natural killer (NK) cell response. NK cells with inhibitory killer cell immunoglobulin-like receptors for nonself MHC exhibit transient alloreactivity after hematopoietic stem cell transplantation (HSCT). We analyzed 3866 recipients in the
PMID 26456260

Interaction of a dengue virus NS1-derived peptide with the inhibitory receptor KIR3DL1 on natural killer cells.

Townsley E1, O'Connor G2, Cosgrove C3, Woda M1, Co M1, Thomas SJ4, Kalayanarooj S5, Yoon IK6, Nisalak A6, Srikiatkhachorn A1, Green S1, Stephens HA7, Gostick E8, Price DA8,9, Carrington M2,3, Alter G3, McVicar DW2, Rothman AL10, Mathew A1.
Clinical and experimental immunology.Clin Exp Immunol.2016 Mar;183(3):419-30. doi: 10.1111/cei.12722. Epub 2015 Nov 24.
Killer immunoglobulin-like receptors (KIRs) interact with human leucocyte antigen (HLA) class I ligands and play a key role in the regulation and activation of NK cells. The functional importance of KIR-HLA interactions has been demonstrated for a number of chronic viral infections, but to date only
PMID 26439909

Diversity in KIR gene repertoire in HIV-1 exposed infected and uninfected infants: A study from India.

Chavan VR1, Ahir S1, Ansari Z1, Samant-Mawani P2, Nanavati R3, Mehta P4, Mania-Pramanik J1.
Journal of medical virology.J Med Virol.2016 Mar;88(3):417-25. doi: 10.1002/jmv.24348. Epub 2015 Aug 24.
Natural killer (NK) cells have antiviral activity mediated through killer immunoglobulin receptors (KIRs). Studies have shown the importance of KIR receptors in HIV infection. However reports on association of KIR genes in HIV infection from Indian population are limited, not a single study is repor
PMID 26255774

Japanese Journal

Differential effects of interleukin-12 and interleukin-15 on expansion of NK cell receptor-expressing CD8+ T cells

Sugita Junichi,Tanaka Junji,Yasumoto Atsushi,Shiratori Souichi,Wakasa Kentaro,Kikuchi Misato,Shigematsu Akio,Kondo Takeshi,Asaka Masahiro,Imamura Masahiro
Annals of Hematology 89(2), 115-120, 2010-02
… The cytolytic activity of cells expressing natural killer cell receptors (NKRs) depends on the balance between stimulatory and inhibitory signals. … We investigated both inhibitory NK receptor (CD94/NKG2A) expression and stimulatory NKR (NKG2D) expression on T cells after stimulation with cytokines (IL-12 or IL-15). …
NAID 120002725525

NK Activating Receptor, NKG2D : Function and Biological Roles(<Young Investigator's Symposium>Infection and Immunity)

Ogasawara Kouetsu
Journal of oral biosciences 47(1), 1-5, 2005-02-20
NAID 110003163510

「KIR receptor」

　　[★]

KIR受容体、KIRレセプター、抑制化レセプター、キラー細胞抑制受容体、キラー細胞抑制レセプター、キラー免疫グロブリン様受容体

関: killer cell immunoglobulin-like receptor、killer inhibitory receptor

「キラー細胞抑制受容体」

　　[★]

英: killer inhibitory receptor、KIR receptor
関: KIR受容体、KIRレセプター、抑制化レセプター、キラー細胞抑制レセプター、キラー免疫グロブリン様受容体、キラー細胞免疫グロブリン様受容体

「killer cell immunoglobulin-like receptor」

　　[★]

キラー細胞免疫グロブリン様受容体

関: killer inhibitory receptor、KIR receptor

「inhibitor」

　　[★]

n.

阻害剤、阻害薬、抑制薬、抑制剤、(内在性物質について)インヒビター、抑制物質

関: blocker、depressant、suppressant

「kill」

　　[★]

v.

殺す、死滅させる

関: killing

linux

option

9 KILL プロセスの強制終了

ex.

kill -9 process_id

「inhibitory」

　　[★]

抑制性の、抑制的な、阻害性の

関: inhibiting、suppressive

「inhibitory receptor」

　　[★]

抑制性受容体、抑制性レセプター

「killer」

　　[★]

キラー、殺し屋

[1] Vilches C, Parham P (2002). "KIR: diverse, rapidly evolving receptors of innate and adaptive immunity". Annu Rev Immunol 20: 217–51. doi:10.1146/annurev.immunol.20.092501.134942. PMID 11861603.

[2] Uhrberg M (2005). "The KIR gene family: life in the fast lane of evolution". Eur J Immunol 35 (1): 10–5. doi:10.1002/eji.200425743. PMID 15580655.

リンク元	「KIR receptor」「キラー細胞抑制受容体」「killer cell immunoglobulin-like receptor」
関連記事	「inhibitor」「kill」「inhibitory」「inhibitory receptor」「killer」

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案内

killer inhibitory receptor