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1. 成人の肥満：疫学および危険因子obesity in adults etiology and risk factors [show details]
…medications across a spectrum of diseases, can alter body weight and even lead to obesity Hypothalamic obesity is a rare syndrome in humans that can be regularly produced in animals by injury to the ventromedial …
2. 小児における先天性中枢性低換気症候群および睡眠関連低換気症のその他の原因congenital central hypoventilation syndrome and other causes of sleep related hypoventilation in children [show details]
3. 小児や青年の肥満の定義、疫学、病因definition epidemiology and etiology of obesity in children and adolescents [show details]
…progressive severe obesity, which is particularly difficult to treat In the pediatric age group, hypothalamic obesity most often arises after surgical treatment for craniopharyngioma, and usually is associated …
4. 成人の肥満：発生率、スクリーニング、および評価obesity in adults prevalence screening and evaluation [show details]
…axis if there are signs of disorders such as Cushing syndrome, growth hormone deficiency, or hypothalamic obesity. Routine genetic testing is not recommended, as monogenic disorders that include obesity…
5. 肥満の小児や青年の臨床的評価clinical evaluation of the obese child and adolescent [show details]

English Journal

A comprehensive diagnostic approach to detect underlying causes of obesity in adults.

van der Valk ES, van den Akker ELT, Savas M, Kleinendorst L, Visser JA, Van Haelst MM, Sharma AM, van Rossum EFC.
Obesity reviews : an official journal of the International Association for the Study of Obesity. 2019 Jun;20(6)795-804.
Obesity is a worldwide growing problem. When confronted with obesity, many health care providers focus on direct treatment of the consequences of adiposity. We plead for adequate diagnostics first, followed by an individualized treatment. We provide experience-based and evidence-based practical reco
PMID 30821060

Bone Morphogenetic Protein-8B Expression is Induced in Steatotic Hepatocytes and Promotes Hepatic Steatosis and Inflammation In Vitro.

Mahli A, Seitz T, Beckröge T, Freese K, Thasler WE, Benkert M, Dietrich P, Weiskirchen R, Bosserhoff A, Hellerbrand C.
Cells. 2019 May;8(5).
Non-alcoholic fatty liver disease (NAFLD) is considered to be the hepatic manifestation of the metabolic syndrome. The bone morphogenetic protein-8B (BMP8B) has been shown to be expressed in brown adipose tissues and the hypothalamus and to affect thermogenesis and susceptibility to diet-induced obe
PMID 31096638

Muscogiuri G, Formoso G, Pugliese G, Ruggeri RM, Scarano E, Colao A, .
Reviews in endocrine & metabolic disorders. 2019 May;().
Prader-Willi syndrome (PWS) is a genetic disorder characterized by short stature, low lean body mass, muscular hypotonia, mental retardation, behavioral abnormalities, dysmorphic features, and excessive appetite with progressive obesity. It is caused by lack of expression of genes on the paternally
PMID 31065942

細井徹,小澤光一郎
薬学雑誌. 乙号 136(6), 827-830, 2016
… Obesity is one of the major risk factors of metabolic syndrome, such as hypertension, hyperlipidemia, and diabetes. … Leptin exerts an anti-obesity effect through the Ob-Rb leptin receptor, which is mainly expressed on hypothalamic neuronal cells. … Recent evidence indicated that one of the mechanisms of obesity may be the development of leptin resistance. …
NAID 130005154182

Insulin-driven translational capacity is impaired in primary fibroblasts of Prader Willi

Meneghello Cristiana,Segat Daniela,Fortunati Elisabetta
Intractable & Rare Diseases Research 5(1), 17-24, 2015
… Prader-Willi (PW) syndrome is a rare genetic disorder characterized by hypothalamic-pituitary abnormalities and severe hypotonia, hyperphagia, behavioural and psychiatric problems. … Absence of satiety leads to severe obesity and frequently to diabetes. …
NAID 130005126196

佐久間一基,松澤陽子,齋藤淳,伊藤浩子,大村昌夫,西川哲男
糖尿病 55(3), 209-214, 2012
症例は38歳女性．父，兄に糖尿病あり．1歳時に，21水酸化酵素欠損症（塩類喪失型）と診断された．成人期はデキサメタゾン補充となり2.5 mg/日まで増量され，体重が増加した．34歳時HbA1c上昇，グリメピリドが開始されたが血糖コントロールが悪化，入院となった．クッシング徴候を認めた．糖尿病性細小血管症，動脈硬化は認めず，高インスリン血症を呈した．薬剤性クッシング症候群，ステロイド糖尿病と考え，グ …
NAID 130004511317