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1. 小児における急性中毒性代謝性脳症acute toxic metabolic encephalopathy in children [show details]
… Reye syndrome is a rapidly progressive encephalopathy with hepatic dysfunction,… Uremic encephalopathy can occur as a complication of advanced acute or chronic renal failure.…
2. 成人における急性中毒性代謝性脳症acute toxic metabolic encephalopathy in adults [show details]
… postprandial confusion. In chronic hepatic encephalopathy, the findings tend to fluctuate with periods of remission interspersed. In acute hepatic encephalopathy, an explosive, progressive course develops after …
3. アルコールの慢性神経学的合併症の概要overview of the chronic neurologic complications of alcohol [show details]
… Wernicke encephalopathy (WE) is an acute syndrome requiring emergent treatment to prevent death and neurologic morbidity. Korsakoff syndrome (KS) refers to a chronic neurologic condition… including those with liver disease and Wernicke encephalopathy (WE), lose a disproportionate amount of subcortical white matter compared with cortical gray matter .… Alcoholic polyneuropathy is a gradually progressive disorder of sensory,…
4. 新生児脳症の病因および発症機序etiology and pathogenesis of neonatal encephalopathy [show details]
… among 83 cases of neonatal encephalopathy from a medicolegal registry than among 250 controls (52 to 10 percent). These lesions included fetal thrombotic vasculopathy, chronic villitis with obliterative …
5. 成人における肝性脳症：治療hepatic encephalopathy in adults treatment [show details]
…hepatic encephalopathy in patients with chronic liver disease. The pathogenesis, clinical manifestations, and diagnosis of hepatic encephalopathy and the approach to patients with hepatic encephalopathy in …

English Journal

Dl-3-n-butylphthalide promotes remyelination process in cerebral white matter in rats subjected to ischemic stroke.

Cheng X, Wang H, Liu C, Zhong S, Niu X, Zhang X, Qi R, Zhao S, Zhang X, Qu H, Zhao C.
Brain research. 2019 Aug;1717()167-175.
Remyelination has been widely noticed as an important repair mechanism triggered after a stroke-induced white matter injury, but it often fails due to the lack of recruitment of the oligodendrocyte progenitor cells (OPCs) to the demyelinated area and the inadequate differentiation of OPCs. Racemic d
PMID 30986406

DL-3-n-butylphthalide alleviates vascular cognitive impairment by regulating endoplasmic reticulum stress and the Shh/Ptch1 signaling-pathway in rats.

Niu XL, Jiang X, Xu GD, Zheng GM, Tang ZP, Yin N, Li XQ, Yang YY, Lv PY.
Journal of cellular physiology. 2019 Aug;234(8)12604-12614.
DL-3-n-butylphthalide (NBP) has been approved to be effective in improving cognitive deficits. The aim of the current study was to determine whether NBP protects against cognitive deficits in a rat model of vascular dementia (VD) induced by chronic cerebral hypoperfusion (CCH) by regulating the soni
PMID 30306574

Augmented improvement of cognition and memory by aripiprazole add-on for cilostazol treatment in the chronic cerebral hypoperfusion mouse model.

Park SY, Kim HY, Lee YS, Heo HJ, Shin HK, Lee WS, Hong KW, Kim CD.
Behavioural brain research. 2019 Jun;365()133-140.
Cerebrovascular dysfunction is associated with cognitive impairment in vascular dementia patients. This study aimed to explore augmented improvement of cognition and memory by aripiprazole add-on for cilostazol treatment in vascular dementia model. Male C57BL/6 mice were subjected to BCAS, and spati
PMID 30851315

Japanese Journal

老年者のＰｒｏｇｒｅｓｓｉｖｅ　ｓｕｂｃｏｒｔｉｃａｌ　ｖａｓｃｕｌａｒ　ｅｎｃｅｐｈａｌｏｐａｔｈｙにおける脳血管透過性異常について

小山晃,渥美哲至,川上明男,石川厚,宮谷信行
脳卒中 10(4), 364-368, 1988
… 老年者のprogressive subcortical vascular encephalopathy (PSVE) における脳血管透過性の関与を知ることを目的に老年者の慢性期脳梗塞患者において髄液, 血清アルブミン比及びIgG比の検討を行った. …
NAID 130003630738