WordNet
- the approximate amount of something (usually used prepositionally as in `in the region of' (同)neighborhood
- the extended spatial location of something; "the farming regions of France"; "religions in all parts of the world"; "regions of outer space" (同)part
- a knowledge domain that you are interested in or are communicating about; "it was a limited realm of discourse"; "here we enter the region of opinion"; "the realm of the occult" (同)realm
- a large indefinite location on the surface of the Earth; "penguins inhabit the polar regions"
- relating to or causing or involving catalysis; "catalytic reactions"
PrepTutorEJDIC
- (地理的な)『地域』,『地帯』;(特に広大な)地方 / 《複数形で》(宇宙などの)区分,界,属 / (身体の)部分 / (学問などの)分野,領域 / 《複数形で》(都会から離れた)地方
- 触媒[作用]の
UpToDate Contents
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- 1. 慢性閉塞性肺疾患（COPD）：危険因子およびリスク低減 chronic obstructive pulmonary disease risk factors and risk reduction
- 2. 血管新生阻害剤の概要 overview of angiogenesis inhibitors
- 3. HIVプロテアーゼ阻害剤 hiv protease inhibitors
- 4. 松果体部腫瘍 pineal gland masses
- 5. 慢性骨髄性白血病の細胞生物学および分子生物学 cellular and molecular biology of chronic myeloid leukemia
English Journal
- Vaccines against Clostridium perfringens Alpha-toxin.
- Nagahama M.Author information Department of Microbiology, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro- cho, Tokushima 770-8514, Japan. nagahama@ph.bunri-u.ac.jp.AbstractClostridium perfringens alpha-toxin is thought to be an important agent in gas gangrene, which is a lifethreatening infection with fever, pain, edema, myonecrosis, and gas production. The toxin (370 residues) is composed of an N-terminal domain (1-250 residues, N-domain) in which the catalytic site is found and a C-terminal domain (251-370 residues, C-domain) responsible for binding to membranes. During the past decade, recombinant DNA technology has been employed to develop second-generation vaccines, including site-directed mutants and the C-domain of the toxin, to prevent gas gangrene. These immunities have led to protection against the lethal effects of wild-type C. perfringens in mice. C-domain vaccines are capable of protecting against heterologous clostridia causing clostridial myonecrosis. This article summarizes the current knowledge on vaccines against alpha-toxin.
- Current pharmaceutical biotechnology.Curr Pharm Biotechnol.2014 Nov;14(10):913-7.
- Clostridium perfringens alpha-toxin is thought to be an important agent in gas gangrene, which is a lifethreatening infection with fever, pain, edema, myonecrosis, and gas production. The toxin (370 residues) is composed of an N-terminal domain (1-250 residues, N-domain) in which the catalytic site
- PMID 24372250
- Effects of a domain-selective ACE inhibitor in a mouse model of chronic angiotensin II-dependent hypertension.
- Burger D1, Reudelhuber TL2, Mahajan A3, Chibale K3, Sturrock ED4, Touyz RM.Author information 1*Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Canada.2†Clinical Research Institute of Montreal, Montreal, Canada.3‡Department of Chemistry and South African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town, Rondebosch, South Africa.4§Institute of Infectious Diseases and Molecular Medicine and Division of Medical Biochemistry, University of Cape Town, Cape Town, South Africa.AbstractThe somatic isozyme of ACE (angiotensin I-converting enzyme) comprises two distinct zinc-dependent catalytic domains with different substrate specificities for angiotensin I (cleaved selectively by the C-domain) and bradykinin (cleaved equally efficiently by both the N- and C-domains). Classical ACEIs (ACE inhibitors) target both domains, with side effects such as cough and angio-oedema being attributed, in part, to N-domain inhibition, probably through bradykinin accumulation. We questioned whether a novel C-domain-selective ACEI (lisW-S) has anti-hypertensive effects without influencing bradykinin status. AngII (angiotensin II)-dependent hypertension was studied in mice that express active human renin in the liver (TtRhRen). Compared with wild-type littermates, TtRhRen mice displayed cardiac hypertrophy and had significantly elevated SBP [systolic BP (blood pressure)] as determined by tail cuff sphygmomanometry (150±3 compared with 112±5 mmHg; P<0.05) and telemetry (163±3 compared with 112±2 mmHg; P<0.01). Treatment with the non-selective ACEI lisinopril (1 mg/kg of body weight per day via an osmotic mini-pump for 2 weeks) reduced SBP (127±3 compared with. 154±6; P<0.05). Similarly, treatment with the C-domain selective ACEI lisW-S (lisinopril-tryptophan; 3.6 mg/kg of body weight per day via an osmotic mini-pump for 2 weeks) reduced BP. Treatment with lisinopril or lisW-S significantly reduced levels of AngII in kidneys (~4-fold; P<0.001). Ang-(2-8) [angiotensin-2-8)] was significantly reduced by lisinopril, but not by lisW-S. Plasma bradykinin levels were significantly increased only in the lisinopril group. These data suggest that C-domain-selective ACEIs reduce BP and AngII levels similarly to classical ACEIs. C-domain-selective ACEIs have the potential to avoid undesirable effects on the bradykinin system common to classic ACEIs and may represent a novel approach to the treatment of hypertension.
- Clinical science (London, England : 1979).Clin Sci (Lond).2014 Jul 1;127(1):57-63. doi: 10.1042/CS20130808.
- The somatic isozyme of ACE (angiotensin I-converting enzyme) comprises two distinct zinc-dependent catalytic domains with different substrate specificities for angiotensin I (cleaved selectively by the C-domain) and bradykinin (cleaved equally efficiently by both the N- and C-domains). Classical ACE
- PMID 24506807
- A 3D structural model and dynamics of hepatitis C virus NS3/4A protease (genotype 4a, strain ED43) suggest conformational instability of the catalytic triad: implications in catalysis and drug resistivity.
- Rimmert B1, Sabet S, Ackad E, Yousef MS.Author information 1a Department of Physics , College of Arts and Sciences, Southern Illinois University Edwardsville , Edwardsville , IL , 62026-1654 , USA .AbstractEgypt has the highest prevalence of hepatitis C virus (HCV) infection worldwide with a frequency of 15%. More than 90% of these infections are due to genotype 4, and the subtype 4a (HCV-4a) predominates. Moreover, due to the increased mobility of people, HCV-4a has recently spread to several European countries. The protease domain of the HCV nonstructural protein 3 (NS3) has been targeted for inhibition by several drugs. This approach has had marked success in inhibiting genotype 1 (HCV-1), the predominant genotype in the USA, Europe, and Japan. However, HCV-4a was found to resist inhibition by a number of these drugs, and little progress has been made to understand the structural basis of its drug resistivity. As a step forward, we sequenced the NS3 HCV-4a protease gene (strain ED43) and subsequently built a 3D structural model threaded through a template crystal structure of HCV-1b NS3 protease. The model protease, HCV-4a, shares 83% sequence identity with the template protease, HCV-1b, and has nearly identical rigid structural features. Molecular dynamics simulations predict similar overall dynamics of the two proteases. However, local dynamics and 4D analysis of the interactions between the catalytic triad residues (His57, Asp81, and Ser139) indicate conformational instability of the catalytic site in HCV-4a NS3 protease. These results suggest that the divergent dynamics behavior, more than the rigid structure, could be related to the altered catalytic activity and drug resistivity seen in HCV-4a.
- Journal of biomolecular structure & dynamics.J Biomol Struct Dyn.2014 Jun;32(6):950-8. doi: 10.1080/07391102.2013.800001. Epub 2013 Jun 14.
- Egypt has the highest prevalence of hepatitis C virus (HCV) infection worldwide with a frequency of 15%. More than 90% of these infections are due to genotype 4, and the subtype 4a (HCV-4a) predominates. Moreover, due to the increased mobility of people, HCV-4a has recently spread to several Europea
- PMID 23768174
Japanese Journal
- Factor X Deficiency with Heterozygous Mutations of Novel p.G435S and Known p.G244R in a Patient Presenting with Severe Umbilical Hemorrhage
- Ｔｈｅ Ｋｕｒｕｍｅ Ｍｅｄｉｃａｌ Ｊｏｕｒｎａｌ, 2017
- NAID 130005439839
- Cloning and expression of a novel catechol-<i>O</i>-methyltransferase in common marmosets
- Ｔｈｅ Ｊｏｕｒｎａｌ ｏｆ Ｖｅｔｅｒｉｎａｒｙ Ｍｅｄｉｃａｌ Ｓｃｉｅｎｃｅ 79(2), 267-272, 2017
- NAID 130005316105
- 金属超微粒子による各種炭素材料の触媒化学的エッチング
- 炭素 2016(274), 145-154, 2016
- NAID 130005420057
Related Links
- Definitions of Catalytic Region, synonyms, antonyms, derivatives of Catalytic Region, analogical dictionary of Catalytic Region (English) Français Español Português English » English ↔ search Arabic Bulgarian Chinese ...
- NMT isozymes contain two characteristic structures, the N-terminal region and the catalytic region. Here, it was shown that the N-terminal region of each NMT isozyme is required for isozyme-specific binding to the ribosome. The ...
Related Pictures
★リンクテーブル★
| リンク元 | 「触媒領域」「catalytic domain」「catalytic subunit」「catalytic core」 |
| 関連記事 | 「region」「catalytic」 |
「触媒領域」
「catalytic domain」
「catalytic subunit」
「catalytic core」
「region」
- n.
- 関
- area、district、division、domain、local、moiety、part、partial、piece、portion、realm、regional、segment、segmental、territory、universe
「catalytic」
- 触媒作用の、触媒作用的な、触媒的な、触媒の