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1. 抗原提示細胞antigen presenting cells [show details]
… Recognition of the T cell by these complexes under appropriate conditions leads to the destruction of cells harboring intracellular infectious agents. Antigens from viruses… MHC I-restricted antigen processing is ongoing in most nucleated cells. However, activation of the cell by exposure to microbes or inflammatory cytokines,… positioned for recognition by CD1-restricted T cell receptors (TCRs). CD1 molecules traffic in a similar fashion to MHC II molecules due to an endosomal targeting motif in the cytoplasmic…
2. 細胞性免疫応答the adaptive cellular immune response t cells and cytokines [show details]
…development and for antigen recognition and activation of mature T cells . CD4+ cells recognize antigen presented in the context of MHC class II, while CD8+ cells recognize antigen presented in the context …
3. 移植片対宿主病の病因pathogenesis of graft versus host disease [show details]
… (MHC) or HLA (for Human Leukocyte Antigens) in humans since these molecules underlie the recognition of antigen by T cells.… T cell activation in vivo is complex, depending upon the state of activation of the T cell (resting versus activated, naive versus mature), and on the nature of the antigen-presenting cell… contact with antigen, and so enhances the effecter and memory functions of the immune response. The role of chemokines in GVHD is supported by a phase I/II study of the chemokine (C-C motif) receptor…
4. 抗Ro/SSA抗体および抗La/SSB抗体の抗原抗体系the anti ro ssa and anti la ssb antigen antibody systems [show details]
… and an adjacent RNA recognition motif (RRM), which cooperate to bind RNA. The C-terminus of the protein contains a second RRM followed by a short basic motif ("SBF" domain) and a… La antigens were detected by immunodiffusion or by counter-immunoelectrophoresis. Most laboratories have adopted solid phase assays, including enzyme-linked immunosorbent assays (ELISA) or antigen-coated…
5. 自己免疫性肝炎：病因autoimmune hepatitis pathogenesis [show details]
… determinant in the HLA-class II binding groove crucial to antigen recognition that is carried by the DRB1*0301,… particular motif Leu-Leu-Glu-Gln-Lys-Arg at positions 67-72 of the DR polypeptide, which is encoded by DRB1*0301, DRB3*0101, and DRB1*0401 . The critical amino acid in this motif may be the Lys… studies have described defective Treg function in autoimmune hepatitis, although defective T cell activation may also be relevant . Data suggest that Tregs are numerically impaired in autoimmune liver disease …

English Journal

K1 gene transformation activities in AIDS-related and classic type Kaposi's sarcoma: Correlation with clinical presentation.

Tamanaha-Nakasone A, Uehara K, Tanabe Y, Ishikawa H, Yamakawa N, Toyoda Z, Kurima K, Kina S, Tsuneki M, Okubo Y, Yamaguchi S, Utsumi D, Takahashi K, Arakawa H, Arasaki A, Kinjo T.
Scientific reports. 2019 Apr;9(1)6416.
Kaposi's sarcoma-associated herpesvirus (KSHV) causes both AIDS-related Kaposi's sarcoma (KS) and classic KS, but their clinical presentations are different, and respective mechanisms remain to be elucidated. The KSHV K1 gene is reportedly involved in tumorigenesis through the immunoreceptor tyrosin
PMID 31015491

Myeloid C-type lectin receptors in skin/mucoepithelial diseases and tumors.

Tang C, Makusheva Y, Sun H, Han W, Iwakura Y.
Journal of leukocyte biology. 2019 Apr;().
Myeloid C-type lectin receptors (CLRs), which consist of an extracellular carbohydrate recognition domain and intracellular signal transducing motif such as the immunoreceptor tyrosine-based activation motif (ITAM) or immunoreceptor tyrosine-based inhibitory motif (ITIM), are innate immune receptors
PMID 30964564

Evaluation of CD33 as a genetic risk factor for Alzheimer's disease.

Estus S, Shaw BC, Devanney N, Katsumata Y, Press EE, Fardo DW.
Acta neuropathologica. 2019 Apr;().
In 2011, genome-wide association studies implicated a polymorphism near CD33 as a genetic risk factor for Alzheimer's disease. This finding sparked interest in this member of the sialic acid-binding immunoglobulin-type lectin family which is linked to innate immunity. Subsequent studies found that C
PMID 30949760