immunoreceptor tyrosine based activation motifs

ITAM

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• 1. T細胞受容体シグナル伝達t cell receptor signaling [show details]
  …coreceptor cytoplasmic domains, specifically at motifs known as immunoreceptor tyrosine-based activation motifs (ITAMs). These phosphorylated ITAMs on CD3-zeta serve as binding sites for the zeta chain-associated …
• 2. 肥満細胞：表面受容体とシグナル伝達mast cells surface receptors and signal transduction [show details]
  … transduction. Crosslinking of Fc-epsilon-RI leads to phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of the cytoplasmic domain of both the beta and gamma subunits of the receptor …
• 3. 免疫不全症を引き起こすCD3／T細胞受容体複合体疾患cd3 t cell receptor complex disorders causing immunodeficiency [show details]
  …and differentiation pathway via a motif in the cytoplasmic domain called the immunoreceptor tyrosine-based activation motif (ITAM) There are a number of molecules involved in early signal transduction …
• 4. ホジキンリンパ腫におけるエプスタイン・バール・ウイルスthe role of epstein barr virus in hodgkin lymphoma [show details]
  …with LMP1 in the plasma membrane of EBV-infected lymphocytes . LMP2a contains an immunoreceptor tyrosine based activation motif that resembles motifs carried by immunoglobulin molecules. Expression of LMP2a…
• 5. 獲得免疫である体液性免疫応答the adaptive humoral immune response [show details]
  …and Ig-beta interact with Src-family tyrosine kinases through intracellular immunoreceptor tyrosine-based activation motifs (ITAMs). B cell coreceptors can be divided into those that amplify BCR activation …

English Journal

• Molecular mechanisms of immunoreceptors in platelets.

• Kuriri FA, O'Malley CJ, Jackson DE.
• Thrombosis research. 2019 Apr;176()108-114.
• The main role of platelets is to control haemostasis when there is a blood vessel injury in order to minimise blood loss at the injury site. Under normal circumstances, platelets flow freely within blood vessels as the endothelial cells provide a non-adhesion surface. Naturally, bioactive mediators
• PMID 30802692

• Calibration of CAR activation potential directs alternative T cell fates and therapeutic potency.

• Feucht J, Sun J, Eyquem J, Ho YJ, Zhao Z, Leibold J, Dobrin A, Cabriolu A, Hamieh M, Sadelain M.
• Nature medicine. 2019 01;25(1)82-88.
• Chimeric antigen receptors (CARs) are synthetic receptors that target and reprogram T cells to acquire augmented antitumor properties. CD19-specific CARs that comprise CD28 and CD3ζ signaling motifs have induced remarkable responses in patients with refractory leukemia and lymphoma and were recentl
• PMID 30559421

• Identification of a 2-propanol analogue modulating the non-enzymatic function of indoleamine 2,3-dioxygenase 1.

• Albini E, Coletti A, Greco F, Pallotta MT, Mondanelli G, Gargaro M, Belladonna ML, Volpi C, Bianchi R, Grohmann U, Macchiarulo A, Orabona C.
• Biochemical pharmacology. 2018 Dec;158()286-297.
• Indoleamine 2,3 dioxygenase 1 (IDO1) is a metabolic enzyme that catalyzes the conversion of the essential amino acid tryptophan (Trp) into a series of immunoactive catabolites, collectively known as kynurenines. Through the depletion of Trp and the generation of kynurenines, IDO1 represents a key re
• PMID 30391205

Japanese Journal

• Adaptor protein is essential for insect cytokine signaling in hemocytes

• Proceedings of the National Academy of Sciences of the United States of America 107(36), 15862-15867, 2010-09-07
• … Although structure-activity studies have been extensively performed on the GBP and its mutants in Lepidoptera Pseudaletia separata, the signaling pathway of GBP-dependent activation of plasmatocytes remains unknown. …
• NAID 80021284424

• 円二色性分光法による変異型高親和性IgE受容体β鎖ITAM領域の構造解析

• 寺田 知新,村山 幸一,恵良 聖一,羅 智靖
• 日本生理学会大会発表要旨集 2008(0), 097-097, 2008
• … chain ITAM shows a notable depature from the consensus immunoreceptor tyrosine-based activation motif (ITAM) sequence with the presence of the third tyrosine between the two canonical tyrosines (YX5YX3Y). … ITAM motifs FFF, FYF, YFY, FYY and YYF by circular dichroism(CD) spectroscopy. …
• NAID 130007039591

• Differential roles of N- and C-terminal immunoreceptor tyrosine-based inhibition motifs during inhibition of cell activation by killer cell inhibitory receptors

• BRUHNS P.
• J. Immunol. 162, 3168, 1999
• NAID 80011020050

Related Links

• Immunoreceptor Tyrosine Based Activation Motif - an overview ...

Immunoreceptor Tyrosine Based Activation Motif Immunoreceptor tyrosine-based activation motif (ITAM) is an important signaling component for a number of immunoglobulin-like receptors including T-cell receptors, B-cell receptors ...

• Immunoreceptor tyrosine-based activation motif (ITAM), a ...

Immunoreceptor tyrosine-based activation motif (ITAM), a unique module linking antigen and Fc receptors to their signaling cascades. Isakov N(1). Author information: (1)Department of Microbiology and Immunology, Faculty of ...

• Immunoreceptor tyrosine-based inhibition motifs - ScienceDirect

Cells that are activated following ligation of receptors bearing immunoreceptor tyrosine-based activation motifs (ITAMs) can be negatively regulated by other receptors bearing immunoreceptor tyrosine-based inhibition motifs (ITIMs).

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★リンクテーブル★

リンク元	「ITAM」
関連記事	「base」「activation」「immunoreceptor」

「ITAM」

　　[★]

日

免疫受容活性化チロシンモチーフ

英

immunoreceptor tyrosine-based activation motif, immunoreceptor tyrosine based activation motifs

同

ARAM, antigen recognition activation motif

関

ITIM immunoreceptor tyrosine-based inhibition motif、immunoreceptor tyrosine-based activating motifs ITAMs

ITAMを有する分子で分類

1つ有する

• Igα
• Igβ
• CD3δ
• CD3ε
• CD3γ

3つ有する

• ζ

受容体で分類

BCRからのシグナル伝達

• B細胞のIgα, Igβ

TCRからのシグナル伝達

• T細胞のCD3, CD3, CD3, ζ

NK細胞受容体以下のシグナル伝達

• NK細胞のNKR？、NIR？

Fc受容体以下のシグナル伝達

• Fc受容体をもつ肥満細胞、マクロファージ、単球、好中球、NK細胞

特徴

• チロシンを持ち、共役するキナーゼによりリン酸化される。
• ....YXX[L/I]X6-9YXX[L/I]....

「base」

　　[★]

• n.

• 基礎、基盤、根拠、基本、基底

関

basal、base、basement、basic、basis、element、elementary、evidence、foundation、fundamental、fundamentals、fundus、ground、infrastructure、reason

　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　

「activation」

　　[★]

• 活性化、賦活化、賦活

関

activate、activated、turn on

　 　 　

「immunoreceptor」

　　[★]

• 免疫受容体、免疫レセプター

関

immunologic receptor