- 関
- vascular endothelial growth factor receptor-1
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/01/01 03:04:47」(JST)
[Wiki en表示]
| FLT1 |
|
| Available structures |
| PDB |
Ortholog search: PDBe RCSB |
| List of PDB id codes |
|
1FLT, 1QSV, 1QSZ, 1QTY, 1RV6, 2XAC, 3HNG, 4CKV, 4CL7, 5EX3
|
|
|
| Identifiers |
| Aliases |
FLT1, FLT, FLT-1, VEGFR-1, VEGFR1, fms related tyrosine kinase 1 |
| External IDs |
MGI: 95558 HomoloGene: 134179 GeneCards: FLT1 |
| Gene location (Human) |
|
| Chr. |
Chromosome 13 (human)[1] |
|
|
| Band |
13q12.3 |
Start |
28,300,344 bp[1] |
| End |
28,495,145 bp[1] |
|
| Gene location (Mouse) |
|
| Chr. |
Chromosome 5 (mouse)[2] |
|
|
| Band |
5 G3|5 87.01 cM |
Start |
147,561,604 bp[2] |
| End |
147,726,011 bp[2] |
|
| RNA expression pattern |
|
| More reference expression data |
|
| Gene ontology |
| Molecular function |
• vascular endothelial growth factor-activated receptor activity
• transferase activity
• nucleotide binding
• protein kinase activity
• VEGF-B-activated receptor activity
• placental growth factor-activated receptor activity
• kinase activity
• protein binding
• transmembrane receptor protein tyrosine kinase activity
• VEGF-A-activated receptor activity
• protein tyrosine kinase activity
• ATP binding
• growth factor binding
|
| Cellular component |
• cytoplasm
• integral component of membrane
• endosome
• focal adhesion
• membrane
• receptor complex
• integral component of plasma membrane
• extracellular region
• extracellular space
• plasma membrane
• actin cytoskeleton
|
| Biological process |
• positive regulation of vascular endothelial growth factor receptor signaling pathway
• cell differentiation
• blood vessel morphogenesis
• vascular endothelial growth factor receptor-1 signaling pathway
• positive regulation of MAP kinase activity
• monocyte chemotaxis
• positive regulation of phospholipase C activity
• transmembrane receptor protein tyrosine kinase signaling pathway
• vascular endothelial growth factor signaling pathway
• phosphorylation
• positive regulation of angiogenesis
• positive regulation of phosphatidylinositol 3-kinase activity
• multicellular organism development
• chemotaxis
• protein phosphorylation
• vascular endothelial growth factor receptor signaling pathway
• embryonic morphogenesis
• angiogenesis
• protein autophosphorylation
• positive regulation of phosphatidylinositol 3-kinase signaling
• peptidyl-tyrosine phosphorylation
• cellular response to vascular endothelial growth factor stimulus
• cell migration
• positive regulation of MAPK cascade
• positive regulation of cell proliferation
• positive regulation of cell migration
|
| Sources:Amigo / QuickGO |
|
| Orthologs |
| Species |
Human |
Mouse |
| Entrez |
|
|
| Ensembl |
|
|
| UniProt |
|
|
| RefSeq (mRNA) |
|
|
NM_001159920
NM_001160030
NM_001160031
NM_002019
|
|
|
| RefSeq (protein) |
|
|
NP_001153392
NP_001153502
NP_001153503
NP_002010
|
|
|
| Location (UCSC) |
Chr 13: 28.3 – 28.5 Mb |
Chr 13: 147.56 – 147.73 Mb |
| PubMed search |
[3] |
[4] |
| Wikidata |
| View/Edit Human |
View/Edit Mouse |
|
Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the FLT1 gene.[5]
Contents
- 1 Function
- 2 Interactions
- 3 See also
- 4 References
- 5 Further reading
Function
Oncogene FLT belongs to the src gene family and is related to oncogene ROS (MIM 165020). Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The sequence structure of the FLT gene resembles that of the FMS gene (MIM 164770); hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.[supplied by OMIM][6]
Interactions
FLT1 has been shown to interact with PLCG1[7] and vascular endothelial growth factor B (VEGF-B).[8][9]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000102755 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029648 - Ensembl, May 2017
- ^ "Human PubMed Reference:".
- ^ "Mouse PubMed Reference:".
- ^ Shibuya M, Yamaguchi S, Yamane A, Ikeda T, Tojo A, Matsushime H, Sato M (Apr 1990). "Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family". Oncogene. 5 (4): 519–24. PMID 2158038.
- ^ "Entrez Gene: FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)".
- ^ Cunningham SA, Arrate MP, Brock TA, Waxham MN (Nov 1997). "Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites". Biochemical and Biophysical Research Communications. 240 (3): 635–9. doi:10.1006/bbrc.1997.7719. PMID 9398617.
- ^ Olofsson B, Korpelainen E, Pepper MS, Mandriota SJ, Aase K, Kumar V, Gunji Y, Jeltsch MM, Shibuya M, Alitalo K, Eriksson U (Sep 1998). "Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells". Proceedings of the National Academy of Sciences of the United States of America. 95 (20): 11709–14. doi:10.1073/pnas.95.20.11709. PMC 21705 . PMID 9751730.
- ^ Makinen T, Olofsson B, Karpanen T, Hellman U, Soker S, Klagsbrun M, Eriksson U, Alitalo K (Jul 1999). "Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1". The Journal of Biological Chemistry. 274 (30): 21217–22. doi:10.1074/jbc.274.30.21217. PMID 10409677.
Further reading
- Petrova TV, Makinen T, Alitalo K (Nov 1999). "Signaling via vascular endothelial growth factor receptors". Experimental Cell Research. 253 (1): 117–30. doi:10.1006/excr.1999.4707. PMID 10579917.
- Sato Y, Kanno S, Oda N, Abe M, Ito M, Shitara K, Shibuya M (May 2000). "Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction". Annals of the New York Academy of Sciences. 902 (1): 201–5; discussion 205–7. doi:10.1111/j.1749-6632.2000.tb06314.x. PMID 10865839.
- Boyd AW, Lackmann M (Dec 2001). "Signals from Eph and ephrin proteins: a developmental tool kit". Science's STKE : Signal Transduction Knowledge Environment. 2001 (112): RE20. doi:10.1126/stke.2001.112.re20. PMID 11741094.
- Luttun A, Tjwa M, Carmeliet P (Dec 2002). "Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders". Annals of the New York Academy of Sciences. 979: 80–93. doi:10.1111/j.1749-6632.2002.tb04870.x. PMID 12543719.
- Maynard SE, Venkatesha S, Thadhani R, Karumanchi SA (May 2005). "Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia". Pediatric Research. 57 (5 Pt 2): 1R–7R. doi:10.1203/01.PDR.0000159567.85157.B7. PMID 15817508.
- Shibuya M (2007). "Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis". Angiogenesis. 9 (4): 225–30; discussion 231. doi:10.1007/s10456-006-9055-8. PMID 17109193.
- Widmer M, Villar J, Benigni A, Conde-Agudelo A, Karumanchi SA, Lindheimer M (Jan 2007). "Mapping the theories of preeclampsia and the role of angiogenic factors: a systematic review". Obstetrics and Gynecology. 109 (1): 168–80. doi:10.1097/01.AOG.0000249609.04831.7c. PMID 17197602.
- López-Novoa JM (Mar 2007). "Soluble endoglin is an accurate predictor and a pathogenic molecule in pre-eclampsia". Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. 22 (3): 712–4. doi:10.1093/ndt/gfl768. PMID 17210583.
- Poesen K, Lambrechts D, Van Damme P, Dhondt J, Bender F, Frank N, Bogaert E, Claes B, Heylen L, Verheyen A, Raes K, Tjwa M, Eriksson U, Shibuya M, Nuydens R, Van Den Bosch L, Meert T, D'Hooge R, Sendtner M, Robberecht W, Carmeliet P (Oct 2008). "Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration". The Journal of Neuroscience. 28 (42): 10451–9. doi:10.1523/JNEUROSCI.1092-08.2008. PMID 18923022.
- Joukov V, Kaipainen A, Jeltsch M, Pajusola K, Olofsson B, Kumar V, Eriksson U, Alitalo K (Nov 1997). "Vascular endothelial growth factors VEGF-B and VEGF-C". Journal of Cellular Physiology. 173 (2): 211–5. doi:10.1002/(SICI)1097-4652(199711)173:2<211::AID-JCP23>3.0.CO;2-H. PMID 9365524.
- Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, MacDonald DD, Jin DK, Shido K, Kerns SA, Zhu Z, Hicklin D, Wu Y, Port JL, Altorki N, Port ER, Ruggero D, Shmelkov SV, Jensen KK, Rafii S, Lyden D (Dec 2005). "VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche". Nature. 438 (7069): 820–7. doi:10.1038/nature04186. PMC 2945882 . PMID 16341007.
|
PDB gallery
|
|
|
|
1flt: VEGF IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR
|
|
|
|
1qsv: THE VEGF-BINDING DOMAIN OF FLT-1, 20 NMR STRUCTURES
|
|
|
|
1qsz: THE VEGF-BINDING DOMAIN OF FLT-1 (MINIMIZED MEAN)
|
|
|
|
1qty: VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH DOMAIN 2 OF THE FLT-1 RECEPTOR
|
|
|
|
1rv6: Crystal Structure of PlGF in Complex with Domain 2 of VEGFR1
|
|
|
|
Receptors: growth factor receptors
|
| Type I cytokine receptor |
- Nerve growth factors: Ciliary neurotrophic factor
- Erythropoietin
|
| Receptor protein serine/threonine kinase |
- TGF pathway: TGF-beta
- Activin
- Bone morphogenetic protein
|
| Receptor tyrosine kinase |
|
|
- Nerve growth factors: high affinity Trk
|
|
|
- Somatomedin
- Insulin-like growth factor 1
|
- ErbB/Epidermal growth factor
|
|
|
|
| Tumor necrosis factor receptor |
- Nerve growth factors: Low affinity/p75
|
| Ig superfamily |
- Platelet-derived growth factor
- Stem cell factor
|
| Other/ungrouped |
- Somatomedin
- Insulin-like growth factor 2
|
|
Protein kinases: tyrosine kinases (EC 2.7.10)
|
|
Receptor tyrosine kinases (EC 2.7.10.1)
|
| Growth factor receptors |
| EGF receptor family |
|
| Insulin receptor family |
|
| PDGF receptor family |
- CSF1R
- FLT3
- KIT
- PDGFR (PDGFRA
- PDGFRB)
|
| FGF receptor family |
|
| VEGF receptors family |
|
| HGF receptor family |
|
| Trk receptor family |
|
|
| EPH receptor family |
- EPHA1
- EPHA2
- EPHA3
- EPHA4
- EPHA5
- EPHA6
- EPHA7
- EPHA8
- EPHB1
- EPHB2
- EPHB3
- EPHB4
- EPHB5
- EPHB6
- EPHX
|
| LTK receptor family |
|
| TIE receptor family |
|
| ROR receptor family |
|
| DDR receptor family |
|
| PTK7 receptor family |
|
| RYK receptor family |
|
| MuSK receptor family |
|
| ROS receptor family |
|
| AATYK receptor family |
|
| AXL receptor family |
|
| RET receptor family |
|
| uncategorised |
|
|
|
|
Non-receptor tyrosine kinases (EC 2.7.10.2)
|
| ABL family |
|
| ACK family |
|
| CSK family |
|
| FAK family |
|
| FES family |
|
| FRK family |
|
| JAK family |
|
| SRC-A family |
|
| SRC-B family |
|
| TEC family |
|
| SYK family |
|
|
|
|
Enzymes
|
| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
|
| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
|
| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
|
| Kinetics |
- Enzyme kinetics
- Eadie–Hofstee diagram
- Hanes–Woolf plot
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
|
| Types |
- EC1 Oxidoreductases (list)
- EC2 Transferases (list)
- EC3 Hydrolases (list)
- EC4 Lyases (list)
- EC5 Isomerases (list)
- EC6 Ligases (list)
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- FOXF2 deficiency permits basal-like breast cancer cells to form lymphangiogenic mimicry by enhancing the response of VEGF-C/VEGFR3 signaling pathway.
- Wang QS1, He R2, Yang F2, Kang LJ2, Li XQ1, Fu L3, Sun B4, Feng YM5.
- Cancer letters.Cancer Lett.2018 Apr 28;420:116-126. doi: 10.1016/j.canlet.2018.01.069. Epub 2018 Jan 31.
- PMID 29409810
- Immune cells regulate VEGF signalling via release of VEGF and antagonistic soluble VEGF receptor-1.
- Hoeres T1, Wilhelm M1, Smetak M1, Holzmann E1, Schulze-Tanzil G2, Birkmann J1.
- Clinical and experimental immunology.Clin Exp Immunol.2018 Apr;192(1):54-67. doi: 10.1111/cei.13090. Epub 2018 Jan 4.
- PMID 29235095
- TLR9 (Toll-Like Receptor 9) Agonist Suppresses Angiogenesis by Differentially Regulating VEGFA (Vascular Endothelial Growth Factor A) and sFLT1 (Soluble Vascular Endothelial Growth Factor Receptor 1) in Preeclampsia.
- He B1, Yang X1, Li Y1, Huang D1, Xu X1, Yang W1, Dai Y1, Zhang H1, Chen Z1, Cheng W2.
- Hypertension (Dallas, Tex. : 1979).Hypertension.2018 Apr;71(4):671-680. doi: 10.1161/HYPERTENSIONAHA.117.10510. Epub 2018 Feb 5.
- PMID 29437897
Japanese Journal
- Screening of DNA Signaling Aptamer from Multiple Candidates Obtained from SELEX with Next-generation Sequencing
- YOSHITOMI Toru,WAYAMA Fumiya,KIMURA Keiko,WAKUI Koji,FURUSHO Hitoshi,YOSHIMOTO Keitaro
- Analytical Sciences 35(1), 113-116, 2019
- … In this study, we discovered DNA signaling aptamers against VEGFR-1. …
- NAID 130007554959
- 新規甲状腺がん治療薬レンバチニブメシル酸塩の創製研究
- 船橋 泰博,鶴岡 明彦
- MEDCHEM NEWS 25(4), 183-188, 2015
- … <p>レンバチニブメシル酸塩（レンバチニブ）はエーザイ筑波研究所にて創製された経口投与可能な受容体チロシンキナーゼを阻害するマルチキナーゼ阻害剤であり、腫瘍血管新生に関わる血管内皮増殖因子受容体VEGFR1～3および線維芽細胞増殖因子受容体FGFR1～4、ならびにがん細胞増殖に関わるRearranged During Transfectionがん原遺伝子RETのチロシンキナーゼ活性を阻害する。 …
- NAID 130007480827
- 新規甲状腺がん治療薬レンバチニブメシル酸塩（レンビマカプセル）の非臨床研究と臨床試験成績
- 鶴岡 明彦,松井 順二,鈴木 拓也 [他],小山 則行,渡辺 達夫,船橋 泰博
- 日本薬理学雑誌 146(5), 283-290, 2015
- … レンバチニブメシル酸塩は，経口投与可能な受容体チロシンキナーゼ阻害薬であり，腫瘍の血管新生に関わる血管内皮増殖因子受容体（VEGFR）1～3，線維芽細胞増殖因子受容体（FGFR）1～4およびRearranged During Transfectionがん原遺伝子（RET）のチロシンキナーゼ活性を阻害する．In vitro血管新生モデルではVEGFおよびFGF誘導の血管新生を阻害し，様々なヒトがん細胞を移植したマウスモ …
- NAID 130005108613
Related Links
- VEGF受容体の種類 3) 4) VEGF受容体は、VEGFR-1（Flt-1）、VEGFR-2（KDR/Flk-1）、VEGFR-3（Flt-4） の3 つのアイソフォームが存在する。 VEGFR-1 とVEGFR-2 は血管内皮細胞に特異的に発現する受容体型チロシンキナーゼ ...
- 血管内皮増殖因子受容体1（VEGFR-1）と単球・マクロファージ細胞の増殖・分化への関与、および慢性間接リウマチ ... 1. 東京大学医科学研究所 腫瘍抑制研究分野 2. 東京女子医科大学薬理学教室 3. キリンビール株式会社医薬カンパニー ...
★リンクテーブル★
[★]
- 英
- vascular endothelial growth factor receptor-1、VEGFR-1
- 関
- 血管内皮増殖因子受容体-1
[★]
血管内皮増殖因子受容体1
- 関
- VEGFR-1
[★]
- 関
- vascular endothelial growth factor receptor、VEGF receptor
[★]
血管内皮増殖因子 vascular endothelial growth factor