WordNet

want to have; "Id like a beer now!"
a kind of person; "Well not see his like again"; "I cant tolerate people of his ilk" (同)ilk
a similar kind; "dogs, foxes, and the like", "we dont want the likes of you around here" (同)the like, the likes of
equal in amount or value; "like amounts"; "equivalent amounts"; "the same amount"; "gave one six blows and the other a like number"; "the same number" (同)same
resembling or similar; having the same or some of the same characteristics; often used in combination; "suits of like design"; "a limited circle of like minds"; "members of the cat family have like dispositions"; "as like as two peas in a pod"; "doglike devotion"; "a dreamlike quality" (同)similar
be fond of; "I like my nephews"
feel about or towards; consider, evaluate, or regard; "How did you like the Presidents speech last night?"
find enjoyable or agreeable; "I like jogging"; "She likes to read Russian novels"
ring slowly; "For whom the bell tolls"
a fee levied for the use of roads or bridges (used for maintenance)
charge a fee for using; "Toll the bridges into New York City"
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
a feeling of pleasure and enjoyment; "Ive always had a liking for reading"; "she developed a liking for gin"
found pleasant or attractive; often used as a combining form; "a well-liked teacher"

PrepTutorEJDIC

…‘を'『好む』,‘が'好きである / 《しばしば否定文で,またwould,《英》shouldと共に用いて》…‘を'望む,…したい / 『好む』;望む / 《複数形で》好み,好きな事
(外観・性質などが)…『に似た』,のような / (やり方,程度などが)…『と同じように』 / …『らしい』,にふさわいし / 《おもに話》たとえば…のような / 《名詞の前にのみ用いて》(性質・外観などが)同じの,(数量が)等しい / 《補語にのみ用いて》似ている,そっくりで / たぶん,おそらく(probably) / (…に)似た人(物),(…と)同等の人(物),匹敵する人(物)《+『of』+『名』》 / …のように / あたかも…のように
〈鐘が〉(にっくり規則的に繰り返して)鳴る / (ゆっくり規則的に繰り返して)〈鐘〉‘を'鳴らす / 〈鐘が〉…‘を'知らせる / 鐘を鳴らすこと / 鐘の音
(橋・道路などの)『使用[通行]料金』,使用税 / (長距離電話などの)『料金』,サービス料 / 《通例単数形で》(災難などの)被害の程度,犠牲(死傷)負数
=sense organ / 受信装置
(…の)『好み』,趣味《+『for』(『to』)+『名』》

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/29 06:53:30」(JST)

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[Wiki en表示]

Toll-like receptor 7, also known as TLR7, is protein that in humans is encoded by the TLR7 gene. Orthologs are found in mammals and birds.^[1]

Function[edit]

TLR7 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on human chromosome X.^[2]

TLR7 recognises single stranded RNA in endosomes, which is a common feature of viral genomes which are internalised by macrophages.

Clinical significance[edit]

Imiquimod acts upon TLR7.^[3]

References[edit]

^ Du X, Poltorak A, Wei Y, Beutler B (September 2000). "Three novel mammalian toll-like receptors: gene structure, expression, and evolution". Eur. Cytokine Netw. 11 (3): 362–71. PMID 11022119. Cite uses deprecated parameters (help)
^ "Entrez Gene: TLR7 toll-like receptor 7".
^ Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S (February 2002). "Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway". Nat. Immunol. 3 (2): 196–200. doi:10.1038/ni758. PMID 11812998. Cite uses deprecated parameters (help)

External links[edit]

Toll-Like Receptor 7 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on the X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 全身性エリテマトーデスの疫学および病因 epidemiology and pathogenesis of systemic lupus erythematosus
2. Toll様受容体：疾患および治療における役割 toll like receptors roles in disease and therapy
3. 外陰および膣の尖圭コンジローマの治療 treatment of vulvar and vaginal warts
4. 分類不能型低ガンマグロブリン血症の病因 pathogenesis of common variable immunodeficiency
5. 幼児血管腫のマネージメント management of infantile hemangiomas

English Journal

The microRNAs Let7c and miR21 are recognized by neuronal Toll-like receptor 7 to restrict dendritic growth of neurons.

Liu HY1, Huang CM2, Hung YF2, Hsueh YP3.
Experimental neurology.Exp Neurol.2015 Jul;269:202-12. doi: 10.1016/j.expneurol.2015.04.011. Epub 2015 Apr 24.
Inflammatory responses are known to play critical roles in the regulation of neurodevelopment and neurodegeneration. Although microglial cells are recognized as professional immune cells in brains, recent evidence suggests that neurons also express important receptors and regulators of innate immuni
PMID 25917529

Toll-like receptor 7 Gln11Leu, c.4-151A/G, and +1817G/T polymorphisms in Crimean Congo hemorrhagic fever.

Arslan S1, Engin A, Özbilüm N, Bakır M.
Journal of medical virology.J Med Virol.2015 Jul;87(7):1090-5. doi: 10.1002/jmv.24174. Epub 2015 Apr 16.
Crimean-Congo hemorrhagic fever (CCHF) is a viral zoonosis. Toll-like receptors (TLRs) initiate signaling cascades leading to the activation of the innate immune system following CCHF infection. In this study, TLR7 (Gln11Leu, c.4-151A/G, and +1817G/T) polymorphisms were investigated in CCHF patients
PMID 25879168

Early clinical evaluation of the intranasal TLR7 agonist GSK2245035: Use of translational biomarkers to guide dosing and confirm target engagement.

Tsitoura D1, Ambery C2, Price M3, Powley W1, Garthside S2, Biggadike K1, Quint D1.
Clinical pharmacology and therapeutics.Clin Pharmacol Ther.2015 Jun 5. doi: 10.1002/cpt.157. [Epub ahead of print]
Modulation of the airways' immune milieu is a key therapeutic goal for remission from respiratory allergies. To explore this hypothesis GSK2245035, a selective toll-like receptor 7 (TLR7) agonist with preferential Type-1 Interferon (IFN)-stimulating properties, was developed for intranasal applicati
PMID 26044169

Japanese Journal

Oxidized Low-Density Lipoprotein Promotes Macrophage Lipid Accumulation via the Toll-Like Receptor 4-Src Pathway

Circulation journal : official journal of the Japanese Circulation Society 79(11), 2509-2516, 2015-11
NAID 40020625326

SIRT1-related inhibition of pro-inflammatory responses and oxidative stress are involved in the mechanism of nonspecific low back pain relief after exercise through modulation of Toll-like receptor 4

The journal of biochemistry 158(4), 299-308, 2015-10
NAID 40020615377

Toll様受容体8はRNAの分解物であるウリジンを認識する

臨床免疫・アレルギー科 = Clinical immunology & allergology 64(3), 294-298, 2015-09
NAID 40020592862

Related Pictures

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★リンクテーブル★

リンク元	「Toll様受容体7」「Toll様レセプター7」「TLR7」
関連記事	「like」「toll」

「Toll様受容体7」

Toll-like receptor 7
Identifiers
Symbols	TLR7; TLR7-like
External IDs	OMIM: 300365 MGI: 2176882 HomoloGene: 75060 ChEMBL: 5936 GeneCards: TLR7 Gene
Gene Ontology
Molecular function	• double-stranded RNA binding; • single-stranded RNA binding; • transmembrane signaling receptor activity; • drug binding; • siRNA binding;
Cellular component	• Golgi membrane; • cytoplasm; • lysosome; • endosome; • endoplasmic reticulum; • endoplasmic reticulum membrane; • plasma membrane; • endosome membrane; • integral to membrane; • early phagosome; • endolysosome membrane;
Biological process	• toll-like receptor signaling pathway; • microglial cell activation involved in immune response; • MyD88-dependent toll-like receptor signaling pathway; • inflammatory response; • I-kappaB phosphorylation; • positive regulation of chemokine production; • positive regulation of interleukin-6 production; • positive regulation of interleukin-8 production; • toll-like receptor 7 signaling pathway; • toll-like receptor 9 signaling pathway; • response to chemical stimulus; • positive regulation of NF-kappaB import into nucleus; • positive regulation of interferon-gamma biosynthetic process; • innate immune response; • positive regulation of interferon-alpha biosynthetic process; • positive regulation of interferon-beta biosynthetic process; • positive regulation of interleukin-8 biosynthetic process; • positive regulation of inflammatory response; • defense response to virus; • pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response; • cellular response to mechanical stimulus;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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