Toll様受容体7

関: Toll-like receptor 7

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/07/28 17:58:15」(JST)

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Toll-like receptor 7, also known as TLR7, is protein that in humans is encoded by the TLR7 gene. Orthologs are found in mammals and birds.^[1]

Function[edit]

TLR7 is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8, on human chromosome X.^[2]

TLR7 recognises single stranded RNA in endosomes, which is a common feature of viral genomes which are internalised by macrophages.

Clinical significance[edit]

Imiquimod acts upon TLR7.^[3]

References[edit]

^ Du X, Poltorak A, Wei Y, Beutler B (September 2000). "Three novel mammalian toll-like receptors: gene structure, expression, and evolution". Eur. Cytokine Netw. 11 (3): 362–71. PMID 11022119.
^ "Entrez Gene: TLR7 toll-like receptor 7".
^ Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S (February 2002). "Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway". Nat. Immunol. 3 (2): 196–200. doi:10.1038/ni758. PMID 11812998.

External links[edit]

Toll-Like Receptor 7 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article on a gene on the X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. Toll様受容体：疾患および治療における役割 toll like receptors roles in disease and therapy
2. 全身性エリテマトーデスの疫学および病因 epidemiology and pathogenesis of systemic lupus erythematosus
3. 分類不能型低ガンマグロブリン血症の病因 pathogenesis of common variable immunodeficiency
4. ヘルパーT細胞サブセット：疾患における分化および役割 t helper subsets differentiation and role in disease
5. リウマチ性疾患の治療における抗マラリア剤 antimalarial drugs in the treatment of rheumatic disease

English Journal

Human placenta-derived stromal cells decrease inflammation, placental injury and blood pressure in hypertensive pregnant mice.

Chatterjee P1, Chiasson VL1, Pinzur L2, Raveh S2, Abraham E2, Jones KA3, Bounds KR1, Ofir R2, Flaishon L2, Chajut A2, Mitchell BM4.
Clinical science (London, England : 1979).Clin Sci (Lond).2016 Apr 1;130(7):513-23. doi: 10.1042/CS20150555. Epub 2015 Dec 18.
Pre-eclampsia, the development of hypertension and proteinuria or end-organ damage during pregnancy, is a leading cause of both maternal and fetal morbidity and mortality, and there are no effective clinical treatments for pre-eclampsia aside from delivery. The development of pre-eclampsia is charac
PMID 26685104

Increased expression of Toll-like receptors 7 and 9 in myasthenia gravis thymus characterized by active Epstein-Barr virus infection.

Cavalcante P1, Galbardi B2, Franzi S3, Marcuzzo S4, Barzago C5, Bonanno S6, Camera G7, Maggi L8, Kapetis D9, Andreetta F10, Biasiucci A11, Motta T12, Giardina C13, Antozzi C14, Baggi F15, Mantegazza R16, Bernasconi P17.
Immunobiology.Immunobiology.2016 Apr;221(4):516-27. doi: 10.1016/j.imbio.2015.12.007. Epub 2015 Dec 12.
Considerable data implicate the thymus as the main site of autosensitization to the acetylcholine receptor in myasthenia gravis (MG), a B-cell-mediated autoimmune disease affecting the neuromuscular junction. We recently demonstrated an active Epstein-Barr virus (EBV) infection in the thymus of MG p
PMID 26723518

Splenic RNA and MicroRNA Mimics Promote Complement Factor B Production and Alternative Pathway Activation via Innate Immune Signaling.

Zou L1, Feng Y1, Xu G2, Jian W2, Chao W3.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2016 Mar 15;196(6):2788-98. doi: 10.4049/jimmunol.1502106. Epub 2016 Feb 17.
Complement factor B (cfB) is an essential component of the alternative pathway (AP) and plays an important role in the pathogenesis of polymicrobial sepsis. However, the mechanism leading to cfB production and AP activation during sepsis remains poorly understood. In this study, we found that plasma
PMID 26889043

Japanese Journal

Lactobacillus acidophilus L-92 Cells Activate Expression of Immunomodulatory Genes in THP-1 Cells

YANAGIHARA Sae,GOTO Hiroaki,HIROTA Tatsuhiko,FUKUDA Shinji,OHNO Hiroshi,YAMAMOTO Naoyuki
Bioscience of Microbiota, Food and Health 33(4), 157-164, 2014
… Two transmembrane receptor genes, TLR7 and ICAM1, were also upregulated in the early phase of treatment. …
NAID 130004680094

Toll-Like Receptors Required for Dermatophagoides farinae to Activate NF-κB

Kitajima Takaaki,Muroi Masashi,Yamashita Naomi [他],Tanamoto Ken-ichi
Biological and Pharmaceutical Bulletin 37(1), 74-80, 2014
… The excrement extract also activated NF-κB in HEK293 cells expressing TLR1/TLR2, TLR2/TLR6 and CD14/TLR4/MD-2, whereas no activation was observed in cells expressing TLR3, TLR5, TLR7, TLR8 or TLR9. …
NAID 130003382102

TLR7の反応による自己免疫の誘導とGTPase (特集自然免疫と炎症・自己免疫)

齋藤伸一郎
臨床免疫・アレルギー科 60(6), 596-602, 2013-12
NAID 40019921754

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リンク元	「Toll様受容体7」
関連記事	「TL」

「Toll様受容体7」

Toll-like receptor 7
Identifiers
Symbols	TLR7; TLR7-like
External IDs	OMIM: 300365 MGI: 2176882 HomoloGene: 75060 ChEMBL: 5936 GeneCards: TLR7 Gene
Gene Ontology
Molecular function	• double-stranded RNA binding; • single-stranded RNA binding; • transmembrane signaling receptor activity; • drug binding; • siRNA binding;
Cellular component	• Golgi membrane; • cytoplasm; • lysosome; • endosome; • endoplasmic reticulum; • endoplasmic reticulum membrane; • plasma membrane; • endosome membrane; • integral to membrane; • early phagosome; • endolysosome membrane;
Biological process	• toll-like receptor signaling pathway; • microglial cell activation involved in immune response; • MyD88-dependent toll-like receptor signaling pathway; • inflammatory response; • I-kappaB phosphorylation; • positive regulation of chemokine production; • positive regulation of interleukin-6 production; • positive regulation of interleukin-8 production; • toll-like receptor 7 signaling pathway; • toll-like receptor 9 signaling pathway; • response to chemical stimulus; • positive regulation of NF-kappaB import into nucleus; • positive regulation of interferon-gamma biosynthetic process; • innate immune response; • positive regulation of interferon-alpha biosynthetic process; • positive regulation of interferon-beta biosynthetic process; • positive regulation of interleukin-8 biosynthetic process; • positive regulation of inflammatory response; • defense response to virus; • pathogen-associated molecular pattern dependent induction by symbiont of host innate immune response; • cellular response to mechanical stimulus;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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英: Toll-like receptor 7、TLR7
関: Toll様レセプター7

「TL」

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[pmid11022119-1] Du X, Poltorak A, Wei Y, Beutler B (September 2000). "Three novel mammalian toll-like receptors: gene structure, expression, and evolution". Eur. Cytokine Netw. 11 (3): 362–71. PMID 11022119.

[2] "Entrez Gene: TLR7 toll-like receptor 7".

[pmid11812998-3] Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S (February 2002). "Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway". Nat. Immunol. 3 (2): 196–200. doi:10.1038/ni758. PMID 11812998.

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TLR7