OATP-C

• 有機アニオン輸送・リペプチドC

関

organic anion transport polypeptide C

WordNet

1. the 3rd letter of the Roman alphabet (同)c
2. (music) the keynote of the scale of C major
3. a general-purpose programing language closely associated with the UNIX operating system

PrepTutorEJDIC

1. carbonの化学記号
2. cesiumの化学記号
3. cadmiumの化学記号

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/12/26 11:32:27」(JST)

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[Wiki en表示]

Solute carrier organic anion transporter family, member 1B1
Identifiers
Symbols	SLCO1B1; HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2; OATPC; SLC21A6
External IDs	OMIM: 604843 HomoloGene: 74575 ChEMBL: 1697668 GeneCards: SLCO1B1 Gene
Gene Ontology Molecular function • sodium-independent organic anion transmembrane transporter activity Cellular component • plasma membrane • integral to plasma membrane • membrane • basolateral plasma membrane Biological process • bile acid metabolic process • organic anion transport • bile acid and bile salt transport • sodium-independent organic anion transport • small molecule metabolic process • transmembrane transport Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	10599	n/a
Ensembl	ENSG00000134538	n/a
UniProt	Q9Y6L6	n/a
RefSeq (mRNA)	NM_006446	n/a
RefSeq (protein)	NP_006437	n/a
Location (UCSC)	Chr 12: 21.28 – 21.39 Mb	n/a
PubMed search	[1]	n/a

Solute carrier organic anion transporter family member 1B1 is a protein that in humans is encoded by the SLCO1B1 gene.

See also

• Solute carrier family

References

Further reading

• Hsiang B, Zhu Y, Wang Z et al. (2000). "A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters". J. Biol. Chem. 274 (52): 37161–8. doi:10.1074/jbc.274.52.37161. PMID 10601278. 
• König J, Cui Y, Nies AT, Keppler D (2000). "A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane". Am. J. Physiol. Gastrointest. Liver Physiol. 278 (1): G156–64. PMID 10644574. 
• Rollinger-Holzinger I, Eibl B, Pauly M et al. (2000). "LST1: a gene with extensive alternative splicing and immunomodulatory function". J. Immunol. 164 (6): 3169–76. PMID 10706707. 
• König J, Cui Y, Nies AT, Keppler D (2000). "Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide". J. Biol. Chem. 275 (30): 23161–8. doi:10.1074/jbc.M001448200. PMID 10779507. 
• Tamai I, Nezu J, Uchino H et al. (2000). "Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family". Biochem. Biophys. Res. Commun. 273 (1): 251–60. doi:10.1006/bbrc.2000.2922. PMID 10873595. 
• Cui Y, König J, Leier I et al. (2001). "Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6". J. Biol. Chem. 276 (13): 9626–30. doi:10.1074/jbc.M004968200. PMID 11134001. 
• Tirona RG, Leake BF, Merino G, Kim RB (2001). "Polymorphisms in OATP-C: identification of multiple allelic variants associated with altered transport activity among European- and African-Americans". J. Biol. Chem. 276 (38): 35669–75. doi:10.1074/jbc.M103792200. PMID 11477075. 
• Jung D, Hagenbuch B, Gresh L et al. (2001). "Characterization of the human OATP-C (SLC21A6) gene promoter and regulation of liver-specific OATP genes by hepatocyte nuclear factor 1 alpha". J. Biol. Chem. 276 (40): 37206–14. doi:10.1074/jbc.M103988200. PMID 11483603. 
• Nozawa T, Nakajima M, Tamai I et al. (2002). "Genetic polymorphisms of human organic anion transporters OATP-C (SLC21A6) and OATP-B (SLC21A9): allele frequencies in the Japanese population and functional analysis". J. Pharmacol. Exp. Ther. 302 (2): 804–13. doi:10.1124/jpet.302.2.804. PMID 12130747. 
• Michalski C, Cui Y, Nies AT et al. (2003). "A naturally occurring mutation in the SLC21A6 gene causing impaired membrane localization of the hepatocyte uptake transporter". J. Biol. Chem. 277 (45): 43058–63. doi:10.1074/jbc.M207735200. PMID 12196548. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
• Tirona RG, Leake BF, Wolkoff AW, Kim RB (2003). "Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation". J. Pharmacol. Exp. Ther. 304 (1): 223–8. doi:10.1124/jpet.102.043026. PMID 12490595. 
• Wang P, Kim RB, Chowdhury JR, Wolkoff AW (2003). "The human organic anion transport protein SLC21A6 is not sufficient for bilirubin transport". J. Biol. Chem. 278 (23): 20695–9. doi:10.1074/jbc.M301100200. PMID 12670950. 
• Nishizato Y, Ieiri I, Suzuki H et al. (2003). "Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics". Clin. Pharmacol. Ther. 73 (6): 554–65. doi:10.1016/S0009-9236(03)00060-2. PMID 12811365. 
• Niemi M, Schaeffeler E, Lang T et al. (2005). "High plasma pravastatin concentrations are associated with single nucleotide polymorphisms and haplotypes of organic anion transporting polypeptide-C (OATP-C, SLCO1B1)". Pharmacogenetics 14 (7): 429–40. doi:10.1097/01.fpc.0000114750.08559.32. PMID 15226675. 
• Huang MJ, Kua KE, Teng HC et al. (2005). "Risk factors for severe hyperbilirubinemia in neonates". Pediatr. Res. 56 (5): 682–9. doi:10.1203/01.PDR.0000141846.37253.AF. PMID 15319464. 
• Campbell SD, de Morais SM, Xu JJ (2005). "Inhibition of human organic anion transporting polypeptide OATP 1B1 as a mechanism of drug-induced hyperbilirubinemia". Chem. Biol. Interact. 150 (2): 179–87. doi:10.1016/j.cbi.2004.08.008. PMID 15535988. 
• Huang CS, Huang MJ, Lin MS et al. (2005). "Genetic factors related to unconjugated hyperbilirubinemia amongst adults". Pharmacogenet. Genomics 15 (1): 43–50. doi:10.1097/01213011-200501000-00007. PMID 15864125. 
• Katz DA, Carr R, Grimm DR et al. (2006). "Organic anion transporting polypeptide 1B1 activity classified by SLCO1B1 genotype influences atrasentan pharmacokinetics". Clin. Pharmacol. Ther. 79 (3): 186–96. doi:10.1016/j.clpt.2005.11.003. PMID 16513443. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

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English Journal

• Primary-like Human Hepatocytes Genetically Engineered to Obtain Proliferation Competence Display Hepatic Differentiation Characteristics in Monolayer and Organotypical Spheroid Cultures.

• Herzog N1, Hansen M1, Miethbauer S1, Schmidtke KU1, Anderer U1, Lupp A2, Sperling S3, Seehofer D3, Damm G3, Scheibner K1, Küpper JH1.
• Cell biology international.Cell Biol Int.2015 Dec 30. doi: 10.1002/cbin.10574. [Epub ahead of print]
• Primary human hepatocytes are in great demand during drug development and in hepatology. However, both scarcity of tissue supply and donor variability of primary cells create a need for the development of alternative hepatocyte systems. By using a lentivirus vector system to transfer coding sequence
• PMID 26715207

• Quantification of proteins by flow cytometry: Quantification of human hepatic transporter P-gp and OATP1B1 using flow cytometry and mass spectrometry.

• Hogg K1, Thomas J1, Ashford D1, Cartwright J1, Coldwell R2, Weston DJ2, Pillmoor J1, Surry D2, O'Toole P3.
• Methods (San Diego, Calif.).Methods.2015 Jul 1;82:38-46. doi: 10.1016/j.ymeth.2015.03.030. Epub 2015 Apr 24.
• Flow cytometry is a powerful tool for the quantitation of fluorescence and is proven to be able to correlate the fluorescence intensity to the number of protein on cells surface. Mass spectroscopy can also be used to determine the number of proteins per cell. Here we have developed two methods, usin
• PMID 25916617

• An immortalized human blood-nerve barrier endothelial cell line for in vitro permeability studies.

• Yosef N1, Ubogu EE.
• Cellular and molecular neurobiology.Cell Mol Neurobiol.2013 Mar;33(2):175-86. doi: 10.1007/s10571-012-9882-7. Epub 2012 Oct 27.
• Solute and macromolecular transport studies may elucidate nutritional requirements and drug effects in healthy and diseased peripheral nerves. Endoneurial endothelial cells are specialized microvascular cells that form the restrictive blood-nerve barrier (BNB). Primary human endoneurial endothelial
• PMID 23104242

Japanese Journal

• 有機アニオントランスポーターOATP-Cに見られる遺伝子多型と輸送活性

• 杉浦 重樹
• Journal of Nara Medical Association 57(2/3), 41-49, 2006-06-30
• … OATP-Cは肝臓の血液側膜に存在し,様々な化合物を血液中から肝細胞内に取り込む.この取り込みが肝排泄の第一段階であり,薬物動態を考える上で重要なステップである.OATP-Cの遺伝子多型が近年多数同定され,人種による違いや,輸送活性の変化に起因する薬物の体内動態の変動がしだいに明らかになってきた. …
• NAID 110004997555

• OJ-002 Influence of Genetic Polymorphisms of OATP-C on Cholesterol Lowering Effect of Pravastatin(Cardiovascular pharmacology, basic/clinical-2 (H) OJ1,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society)

• Takahashi Reiko,Uchida Shinya,Katou Hideki,Satoh Hiroshi,Hayashi Hideharu,Ohhashi Kyoichi,Watanabe Hiroshi
• Circulation journal : official journal of the Japanese Circulation Society 70(Supplement_I), 234, 2006-03-01
• NAID 110005941702

• Carrier-mediated hepatic uptake of a novel non-renal excretion type uric acid generation inhibitor, Y-700

• Sai Yoshimichi,Kato Yukio,Nakamura Keiko,Kato Sayaka,Nishimura Tomohiro,Kubo Yoshiyuki,Tamai Ikumi,Yang Shu,Hu Zhuhan,Yamada Ichimaro,Tsuji Akira
• Journal of Pharmaceutical Sciences 95(2), 336-347, 2006-02
• … Uptake of Y-700 by sinusoidal membrane transporters, such as organic anion transporter (Oat) 2 and organic anion transporting polypeptide (OATP)-B, OATP-C, OATP-8, and Oatp1, could not be detected although uptake of Y-700 in the oocytes expressing sodium/taurocholate cotransporting polypeptide (NTCP) was slightly observed. …
• NAID 120001893504

Related Links

• OATP；Organic anion transporting polypeptide 有機アニオン ...

肝細胞のOATP・・・OATP1B1（別名：OATP-C／OATP2 ） 薬物の血液から肝細胞中への取り込みに関与。 OATP1B1を介して肝臓へ取り込まれる薬剤 メバロチン（プラバスタチン） クレストール（ロスバスタチン） 他 OATP1B1を阻害 ...

• OATP1B1 (OATP-C) OATP1B1 - 日本薬学会第131年会(静岡)

29-0572 OATP1B1 (OATP-C) の輸送活性に与える薬物の影響：OATP1B1 発現細胞を用いた 解析 山下 恵子1, 亀山 良雄1,2, 橋詰 美里1, 小林 カオル1, 細川 正清1, 千葉 寛1 （1 千葉大院薬,2 日本化薬創薬研） 【目的 ...

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★リンクテーブル★

リンク元	「organic anion transport polypeptide C」「有機アニオン輸送ポリペプチドC」
関連記事	「C」「OA」「OAT」「OATP」「Cs」

「organic anion transport polypeptide C」

　　[★]

有機アニオン輸送・リペプチドC

関

OATP-C

「有機アニオン輸送ポリペプチドC」

　　[★]

英

organic anion transport polypeptide C、OATP-C

「C」

　　[★]

• 炭素 carbon
• シトシン cytosine
• システイン cysteine
• シチジン
• セルシウス度 摂氏 degrees Celsius degree C
• 産婦人科領域で「子宮外頚 子宮外頚部 exocervix」を表現するための略語

　 　 　 　

「OA」

　　[★]

• 変形性関節症 osteoarthritis
• 眼白子症 ocular albinism
• 耳神経動脈 otic artery

「OAT」

　　[★] 有機アニオントランスポーター organic anion transporter

「OATP」

　　[★]

関

Organic anion transporting polypeptide

「Cs」

　　[★] セシウム, caesium, cesium