WordNet

simple and healthful and close to nature; "an organic lifestyle"
a fertilizer that is derived from animal or vegetable matter (同)organic fertilizer, organic fertiliser
being or relating to or derived from or having properties characteristic of living organisms; "organic life"; "organic growth"; "organic remains found in rock"
involving or affecting physiology or bodily organs; "an organic disease"
of or relating to foodstuff grown or raised without synthetic fertilizers or pesticides or hormones; "organic eggs"; "organic vegetables"; "organic chicken"
relating or belonging to the class of chemical compounds having a carbon basis; "hydrocarbons are organic compounds"
move something or somebody around; usually over long distances
an exchange of molecules (and their kinetic energy and momentum) across the boundary between adjacent layers of a fluid or across cell membranes
move while supporting, either in a vehicle or in ones hands or on ones body; "You must carry your camping gear"; "carry the suitcases to the car"; "This train is carrying nuclear waste"; "These pipes carry waste water into the river" (同)carry
transport commercially (同)send, ship
wind instrument whose sound is produced by means of pipes arranged in sets supplied with air from a bellows and controlled from a large complex musical keyboard (同)pipe_organ
a fully differentiated structural and functional unit in an animal that is specialized for some particular function
a government agency or instrument devoted to the performance of some specific function; "The Census Bureau is an organ of the Commerce Department"
a periodical that is published by a special interest group; "the organ of the communist party"
the 3rd letter of the Roman alphabet (同)c
(music) the keynote of the scale of C major
a general-purpose programing language closely associated with the UNIX operating system
a negatively charged ion

PrepTutorEJDIC

有機体の,生物の,生物から生じた / (動植物の)器官の / 有機肥料を用いる(を用いて育った)・有機的な,組織的な,系統的な・有機質の
(ある場所からある場所へ)…‘を'『輸送する』,運搬する《+名+from+名+to+名》 / 《文》《受動態で》(…で)…‘を'夢中にする,有頂天にする《+名+with+名》 / 〈罪人〉‘を'流刑にする / 〈U〉輸送,運送,輸送(交通)機関(transportation) / 〈C〉(軍隊や軍需品を運ぶ)輸送船,輸送機
『オルガン』,パイプオルガン(pipe organ),リードオルガン(reed organ),電子オルガン(electronic organ),手回しオルガン(barrel organ) / (動植物の)『器官』 / (政党・会社などの)機関誌,機関紙 / 《しばしば複数形で》(行動・実施などの)組織,機関
carbonの化学記号
陰イオン

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. スタチン誘発性ミオパチー statin myopathy
2. 高アニオンギャップ性代謝性アシドーシス患者におけるΔアニオンギャップ／ΔHCO3比 the anion gap hco3 ratio in patients with a high anion gap metabolic acidosis
3. 薬理ゲノム学の概要 overview of pharmacogenomics
4. 抱合型高ビリルビン血症関連の遺伝性疾患 inherited disorders associated with conjugated hyperbilirubinemia
5. 有機酸血症 organic acidemias

English Journal

Pharmacogenetic Foundations of Therapeutic Efficacy and Adverse Events of Statins.

Arrigoni E1, Del Re M2, Fidilio L3, Fogli S4, Danesi R5, Di Paolo A6.
International journal of molecular sciences.Int J Mol Sci.2017 Jan 6;18(1). pii: E104. doi: 10.3390/ijms18010104.
BACKGROUND: In the era of precision medicine, more attention is paid to the search for predictive markers of treatment efficacy and tolerability. Statins are one of the classes of drugs that could benefit from this approach because of their wide use and their incidence of adverse events.METHODS: Lit
PMID 28067828

Pre-incubation with cyclosporine A potentiates its inhibitory effects on pitavastatin uptake mediated by recombinantly expressed cynomolgus monkey hepatic organic anion transporting polypeptide.

Takahashi T1, Ohtsuka T2, Uno Y3, Utoh M3, Yamazaki H4, Kume T2.
Biopharmaceutics & drug disposition.Biopharm Drug Dispos.2016 Nov;37(8):479-490. doi: 10.1002/bdd.2039. Epub 2016 Oct 14.
Cyclosporine A, an inhibitor of hepatic organic anion transporting polypeptides (OATPs), reportedly increased plasma concentrations of probe substrates, although its maximum unbound blood concentrations were lower than the experimental half-maximal inhibitory (IC50 ) concentrations. Pre-incubation w
PMID 27603548

Statin-associated muscle symptoms and SLCO1B1 rs4149056 genotype in patients with familial hypercholesterolemia.

Khine H1, Yuet WC2, Adams-Huet B3, Ahmad Z4.
American heart journal.Am Heart J.2016 Sep;179:1-9. doi: 10.1016/j.ahj.2016.05.015. Epub 2016 Jun 9.
Patients with familial hypercholesterolemia (FH) may be at increased risk for statin-associated muscle symptoms because they require long-term treatment with high-intensity statin therapy. We sought to determine (1) whether other predisposing factors, including the well-known genetic variant associa
PMID 27595674

Japanese Journal

Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a5

Arakawa Hiroshi,Shirasaka Yoshiyuki,Haga Makoto,Nakanishi Takeo,Tamai Ikumi
Biopharmaceutics and Drug Disposition 33(6), 332-341, 2012
… Fluoroquinolone antimicrobial drugs are absorbed efficiently after oral administration despite of their hydrophilic nature, implying an involvement of carrier-mediated transport in their membrane transport process. … It has been that several fluoroquinolones are substrates of organic anion transporter polypeptides OATP1A2 expressed in human intestine derived Caco-2 cells. …
NAID 120004997009

薬物の体内動態に及ぼすＳＬＣＯ１Ｂ１遺伝子多型の影響と臨床的意義

高根浩
薬学雑誌 131(11), 2011
… Organic anion transporting polypeptide 1B1 (OATP1B1, gene SLCO1B1) is expressed on the basolateral membrane of hepatocytes and can facilitate hepatic uptake of certain clinically relevant drugs such as statins except for fluvastatin, angiotensin converting enzyme inhibitors, angiotensin II receptor antagonists, antidiabetic drug (repaglinide) and anticancer drugs (SN-38 and methotrexate). …
NAID 130001491113

Screening of antibiotics that interact with organic anion-transporting polypeptides 1B1 and 1B3 using fluorescent probes.

Yamaguchi Hiroaki,Takeuchi Toshiko,Okada Masahiro,Kobayashi Minako,Unno Michiaki,Abe Takaaki,Goto Junichi,Hishinuma Takanori,Shimada Miki,Mano Nariyasu
Biological & pharmaceutical bulletin 34(3), 2011
… Hepatic organic anion transporters OATP1B1 and OATP1B3 are expressed at the sinusoidal membrane of hepatocytes and contribute to the hepatic uptake of a wide variety of clinically used drugs. … To identify the antibiotics that interact with the human organic anion transporters OATP1B1 and OATP1B3, we applied a screening system using fluorescent probes. …
NAID 130000657818

★リンクテーブル★

リンク元	「OATP-C」「有機アニオン輸送ポリペプチドC」「SLC21A6」
関連記事	「C」「transport」「organic」「anion transport」「polypeptide」