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the 13th letter of the Roman alphabet (同)m

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Mach number / mark[s] / Monsieur

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1. 慢性閉塞性肺疾患（COPD）：危険因子およびリスク低減 chronic obstructive pulmonary disease risk factors and risk reduction
2. 腹部大動脈瘤の疫学、危険因子、病因および自然経過 epidemiology risk factors pathogenesis and natural history of abdominal aortic aneurysm
3. 関節リウマチの病因 pathogenesis of rheumatoid arthritis
4. 無症候性腹部大動脈瘤のマネージメント management of asymptomatic abdominal aortic aneurysm
5. 複合形質の遺伝の原則 principles of complex trait genetics

English Journal

Human amniotic epithelial stem cells inhibit microglia activation through downregulation of tumor necrosis factor-α, interleukin-1β and matrix metalloproteinase-12 in vitro and in a rat model of intracerebral hemorrhage.

Liang H1, Guan D2, Gao A3, Yin Y1, Jing M1, Yang L1, Ma W1, Hu E1, Zhang X4.Author information 1Key Laboratory of Neurosurgery, College of Heilongjiang Province, First Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China.2Department of Neurosurgery, Qingdao Hiser Medical Group, Qingdao, People's Republic of China.3School of Life Science, Northeast Agricultural University, Harbin, People's Republic of China.4Key Laboratory of Neurosurgery, College of Heilongjiang Province, First Affiliated Hospital of Harbin Medical University, Harbin, People's Republic of China. Electronic address: Xiangtongzhang@Gmail.com.AbstractBACKGROUND AIMS: The molecular mechanisms by which stem cell transplantation improves functional recovery after intracerebral hemorrhage (ICH) are not well understood. Accumulating evidence suggests that microglia cells are activated shortly after ICH and that this activation contributes to secondary ICH-induced brain injury. We studied the effect of human amniotic epithelial stem cells (HAESCs) on microglia activation.
Cytotherapy.Cytotherapy.2014 Apr;16(4):523-34. doi: 10.1016/j.jcyt.2013.11.007. Epub 2014 Jan 11.
BACKGROUND AIMS: The molecular mechanisms by which stem cell transplantation improves functional recovery after intracerebral hemorrhage (ICH) are not well understood. Accumulating evidence suggests that microglia cells are activated shortly after ICH and that this activation contributes to secondar
PMID 24424266

In Crohn's disease fibrosis reduced expression of the miR-29 family enhances collagen expression in intestinal fibroblasts.

Nijhuis A, Biancheri P, Lewis A, Bishop CL, Giuffrida P, Chan C, Feakins RM, Poulsom R, Di Sabatino A, Corazza GR, Macdonald TT, Lindsay JO, Silver AR.AbstractIntestinal fibrosis with stricture formation is a complication of Crohn's disease (CD) that may mandate surgical resection. Accurate biomarkers that reflect the relative contribution of fibrosis to an individual stricture are an unmet need in managing patients with CD. The microRNA (miR)-29 family has been implicated in cardiac, hepatic and pulmonary fibrosis. We investigated the expression of miR-29a, miR-29b and miR-29c in mucosa overlying a stricture in CD patients (SCD) paired with mucosa from non-strictured areas (NSCD). There was significant down-regulation of the miR-29 family in mucosa overlying SCD compared to mucosa overlying NSCD. MiR-29b showed the largest fold-decrease and was selected for functional analysis. Over-expression of miR-29b in CD fibroblasts led to a down-regulation of collagen I and III transcripts and collagen III protein, but did not alter matrix metalloproteinase (MMP)-3, MMP-12 and tissue inhibitor of metalloproteinase (TIMP)-1 production. TGF-β1 up-regulated collagen I and III transcripts and collagen III protein as a consequence of the down-regulation of miR-29b and TGF-β1-induced collagen expression was reversed by exogenous overexpression of miR-29b. Furthermore, serum levels of miR-29 were lower in patients with stricturing disease compared to those without. These data implicate the miR-29 family in the pathogenesis of intestinal fibrosis in CD and provides impetus for the further evaluation of the miR-29 family as biomarkers.
Clinical science (London, England : 1979).Clin Sci (Lond).2014 Mar 18. [Epub ahead of print]
Intestinal fibrosis with stricture formation is a complication of Crohn's disease (CD) that may mandate surgical resection. Accurate biomarkers that reflect the relative contribution of fibrosis to an individual stricture are an unmet need in managing patients with CD. The microRNA (miR)-29 family h
PMID 24641356

Reactive oxygen species induce matrix metalloproteinase-12-dependent degradation of collagen 5 and fibronectin to promote the motility of human umbilical cord derived mesenchymal stem cells.

Yun SP1, Lee SJ, Oh SY, Jung YH, Ryu JM, Suh HN, Kim MO, Oh KB, Han HJ.Author information 1Department of Veterinary Physiology, College of Veterinary Medicine, Research Institute for Veterinary Science, and BK21 PLUS Creative Veterinary Research Center, Seoul National University, Seoul 151-741, Korea.AbstractBACKGROUND AND PURPOSE: Reactive oxygen species (ROS) are potent regulator of stem cell behavior; however, their physiological significance as regards the matrix metalloproteinase (MMP) regulation of the motility of human umbilical cord blood derived mesenchymal stem cells (UCB-MSCs) has not been characterized. In the present study, we investigate the role of hydrogen peroxide (H2 O2 ) in promoting UCB-MSCs motility and its related signaling pathways.
British journal of pharmacology.Br J Pharmacol.2014 Mar 13. doi: 10.1111/bph.12681. [Epub ahead of print]
BACKGROUND AND PURPOSE: Reactive oxygen species (ROS) are potent regulator of stem cell behavior; however, their physiological significance as regards the matrix metalloproteinase (MMP) regulation of the motility of human umbilical cord blood derived mesenchymal stem cells (UCB-MSCs) has not been ch
PMID 24627968

Japanese Journal

PLASMA CELL INFILTRATION AND MUCOID DEGENERATION IN THE MEDIA OF ASCENDING AORTA IN PATIENT WITH CORONARY ARTERY DISEASE

Nagareda Tomofumi,Hirata Nobuaki,Kosakai Yoshio,Ohsawa Masahiko
Journal of Nara Medical Association 62(3,4,5), 55-67, 2011-10-31
… Plasma cells do not appear in non-inflammatorytissue.Methods We compared plasma cells，and matrix metalloproteinase (MMP)-2-，-9- and-12-positive cells immunohistochemically，and we also compared mucoid degenerationand fibrosis determined by staining using a point-counting method，for groups with avariable number of coronary stenotic (≧75%)lesions.Results In patients with one to three coronary stenotic lesions，plasma cells andmucoid degeneration were low in the aortic media. …
NAID 120004973703

Synthesis and Matrix Metalloproteinase-12 Inhibitory Activity of Ageladine A Analogs

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Chemical and Pharmaceutical Bulletin 59(5), 579-596, 2011
… From the matrix metalloproteinase-12 (MMP-12) inhibitory activity assay carried out using the novel analogs, it appeared evident that the halogen atom at the 2-position of pyrrole ring was essential for the inhibitory activity and that the introduction of a bromine atom into the 4-position of pyrrole ring is very effective for producing potent activity. …
NAID 130000648873

Loss of the BMP antagonist USAG-1 ameliorates disease in a mouse model of the progressive hereditary kidney disease Alport syndrome

Tanaka Mari,Asada Misako,Higashi Atsuko Y.,Nakamura Jin,Oguchi Akiko,Tomita Mayumi,Yamada Sachiko,Asada Nariaki,Takase Masayuki,Okuda Tomohiko,Kawachi Hiroshi,Economides Aris N.,Robertson Elizabeth,Takahashi Satoru,Sakurai Takeshi,Goldschmeding Roel,Muso Eri,Fukatsu Atsushi,Kita Toru,Yanagita Motoko
Journal of Clinical Investigation 120(3), 768-777, 2010-03-01
… Furthermore, in cultured mesangial cells, BMP-7 attenuated and USAG-1 enhanced the expression of MMP-12, a protease that may contribute to GBM degradation. …
NAID 120002851415