WordNet

make a map of; show or establish the features of details of; "map the surface of Venus"
to establish a mapping (of mathematical elements or sets) (同)represent
a diagrammatic representation of the earths surface (or part of it)
plan, delineate, or arrange in detail; "map ones future" (同)map out
depict as if on a map; "sorrow was mapped on the mothers face"
explore or survey for the purpose of making a map; "We havent even begun to map the many galaxies that we know exist"
locate within a specific region of a chromosome in relation to known DNA or gene sequences; "map the genes"
the 13th letter of the Roman alphabet (同)m
an enzyme that catalyzes the conversion of a proenzyme to an active enzyme

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1. 前立腺癌の分子生物学 molecular biology of prostate cancer
2. リウマチ性疾患におけるサイトカインネットワーク：治療の意味 cytokine networks in rheumatic diseases implications for therapy
3. 進行非小細胞肺癌に対する遺伝子型による個別治療 personalized genotype directed therapy for advanced non small cell lung cancer
4. 分子標的剤およびその他の生物製剤を用いた癌治療による皮膚合併症 cutaneous complications of molecularly targeted therapy and other biologic agents used for cancer therapy
5. 転移性乳癌における予後および予測因子 prognostic and predictive factors in metastatic breast cancer

Activation of TAK1 by Chemotactic and Growth Factors, and Its Impact on Human Neutrophil Signaling and Functional Responses.

Sylvain-Prévost S1, Ear T1, Simard FA1, Fortin CF1, Dubois CM1, Flamand N2, McDonald PP3.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2015 Dec 1;195(11):5393-403. doi: 10.4049/jimmunol.1402752. Epub 2015 Oct 21.
The MAP3 kinase, TAK1, is known to act upstream of IKK and MAPK cascades in several cell types, and is typically activated in response to cytokines (e.g., TNF, IL-1) and TLR ligands. In this article, we report that in human neutrophils, TAK1 can also be activated by different classes of inflammatory
PMID 26491199

BAALC potentiates oncogenic ERK pathway through interactions with MEKK1 and KLF4.

Morita K1, Masamoto Y1, Kataoka K1, Koya J1, Kagoya Y1, Yashiroda H2, Sato T1,3, Murata S2, Kurokawa M1,4.
Leukemia.Leukemia.2015 Nov;29(11):2248-56. doi: 10.1038/leu.2015.137. Epub 2015 Jun 8.
Although high brain and acute leukemia, cytoplasmic (BAALC) expression is a well-characterized poor prognostic factor in acute myeloid leukemia (AML), neither the exact mechanisms by which BAALC drives leukemogenesis and drug resistance nor therapeutic approaches against BAALC-high AML have been pro
PMID 26050649

Detection of novel germline mutations for breast cancer in non-BRCA1/2 families.

Aloraifi F1, McDevitt T2, Martiniano R1, McGreevy J1, McLaughlin R1, Egan CM1, Cody N2, Meany M2, Kenny E3, Green AJ2, Bradley DG1, Geraghty JG4, Bracken AP1.
The FEBS journal.FEBS J.2015 Sep;282(17):3424-37. doi: 10.1111/febs.13352. Epub 2015 Jul 14.
The identification of the breast cancer susceptibility genes BRCA1 and BRCA2 enhanced clinicians' ability to select high-risk individuals for aggressive surveillance and prevention, and led to the development of targeted therapies. However, BRCA1/2 mutations account for only 25% of familial breast c
PMID 26094658

Suppressive Effect of Tomentosin on the Production of Inﬂammatory Mediators in RAW264.7 Cells

馬田敏幸
産業医科大学雑誌 36(2), 105-114, 2014-06-01
… 白質共役型受容体(GPCR)のリガンドであるリゾホスファチジン酸(LPA)やストレスとしてのソルビトール刺激により誘発されるHB-EGFのシェディングは,それぞれプロテインキナーゼC(PKC)-δ,古典的MAPキナーゼおよびp38MAPキナーゼを介して誘発された.この刺激誘発によるシェディングをN-アセチル-L-システイン(NAC)が阻害したことより,HB-EGFの刺激誘発によるシェディングヘROSが関与することが示唆された.それ …
NAID 110009823329