WordNet

have or establish a relationship to; "She relates well to her peers"
be in a relationship with; "How are these two observations related?" (同)interrelate
give an account of; "The witness related the events"
connected by kinship, common origin, or marriage
being connected either logically or causally or by shared characteristics ; "painting and the related arts"; "school-related activities"; "related to micelle formation is the...ability of detergent actives to congregate at oil-water interfaces" (同)related to
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

(…に)〈事件・事情など〉‘を'『物語る』《+『名』+『to』+『名』》 / (…と)…‘を'『関係させる』,結びつける《+『名』+『to(with)』+『名』》 / 〈物・事が〉(…に)関係がある,かかわる《+『to(with)』+『名(wh・節・句)』》 / (…に)〈人が〉なじむ,順応する《+『to』+『名』》
関係のある
蛋白(たんばく)質
=sense organ / 受信装置

UpToDate Contents

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1. 成人の家族性高コレステロール血症：概要familial hypercholesterolemia in adults overview [show details]
…mutations in the LDLR gene have been identified . The mutations at the LDLR locus have been categorized into four classes of alleles based on the phenotypic behavior of the mutant protein : Class I – Null …
2. 低形成腎renal hypodysplasia [show details]
…or hypodysplasia. CLS is caused by mutations in the LRP4 gene, encoding the low-density lipoprotein receptor-related protein 4 . Infants with CHARGE syndrome (coloboma of the retina or the iris, heart …
3. Gene test interpretation: Familial hypercholesterolemia genes (LDLR, APOB, PCSK9)gene test interpretation familial hypercholesterolemia genes ldlr apob pcsk9 [show details]
… apolipoprotein B (previously called apoB100), the major protein component of LDL. It is responsible for LDL binding to (and uptake by) the LDLR. The full length protein is called apoB100; truncated forms are referred …
4. リポ蛋白糸球体症lipoprotein glomerulopathy [show details]
…lipoprotein levels are determined in part by the binding activities of apo E to the LDL receptor, LDL receptor-related protein, and VLDL receptor. Apo E is composed of 299 amino acids and has a relative molecular …
5. 骨形成不全症：臨床的特徴および診断osteogenesis imperfecta clinical features and diagnosis [show details]
… ocular form of OI . It is caused by deletion of the gene for low-density-lipoprotein (LDL) receptor-related protein 5 (LRP-5). Other characteristic findings include microcephaly; pseudoglioma (inflammatory …

English Journal

Knockdown of Lrp1 in RAW264 cells inhibits osteoclast differentiation and osteoclast-osteoblast interactions in vitro.

Kohara Y, Haraguchi R, Kitazawa R, Kitazawa S.
Biochemical and biophysical research communications. 2020 Mar;523(4)961-965.
Low density lipoprotein receptor-related protein 1 (LRP1), a multifunctional cell surface protein, is expressed in bone marrow-derived macrophages. While LRP1 is thought to be a suppressor of osteoclast differentiation at late stages, its function at early stages remains unclear. Here we demonstrate
PMID 31964526

IgE Contributes to Atherosclerosis and Obesity by Affecting Macrophage Polarization, Macrophage Protein Network, and Foam Cell Formation.

Zhang X, Li J, Luo S, Wang M, Huang Q, Deng Z, de Febbo C, Daoui A, Liew PX, Sukhova GK, Metso J, Jauhiainen M, Shi GP, Guo J.
Arteriosclerosis, thrombosis, and vascular biology. 2020 Mar;40(3)597-610.
By binding to its high-affinity receptor FcεR1, IgE activates mast cells, macrophages, and other inflammatory and vascular cells. Recent studies support an essential role of IgE in cardiometabolic diseases. Plasma IgE level is an independent predictor of human coronary heart disease. Yet, a direct
PMID 31996021

Involvement of chronic unpredictable mild stress-induced hippocampal LRP1 up-regulation in microtubule instability and depressive-like behavior in a depressive-like adult male rat model.

Wang H, Xiao L, Wang H, Wang G.
Physiology & behavior. 2020 Mar;215()112749.
Low-density lipoprotein receptor-related protein 1 (LRP1) and tau play an important role in developing Alzheimer's disease. This study aimed to explore the involvement of LRP1 in microtubule dynamic and depressive-like behavior in a depressive-like rat model. It also investigated whether fluoxetine
PMID 31770536

Japanese Journal

Lactoferrinはヒト歯肉線維芽細胞において細胞増殖と創傷治癒を促進する―<i>in vitro</i>研究

鈴木苗穂
日本歯周病学会会誌 61(1), 18-27, 2019
… また，HGFsにはLactoferrinの受容体であるlow density lipoprotein（LDL）receptor-related protein 1（LRP1）が発現しており，LactoferrinによってHGFsの細胞増殖能と創傷治癒が促進された。 … さらに，Lactoferrinがextracellular signal-related kinase 1/2（ERK1/2）のリン酸化を促進した。 …
NAID 130007626290

An Endocytic Receptor, Megalin-Ligand Interactions : Effects of Glycosylation

Hirano Makoto
Trends in glycoscience and glycotechnology 30(175-177), E155-160, 2018-07
NAID 40021833784

Genome-Wide Association Study of Renal Function Traits: Results from the Japan Multi-Institutional Collaborative Cohort Study

Hishida Asahi,Nakatochi Masahiro,Akiyama Masato,Kamatani Yoichiro,Nishiyama Takeshi,Ito Hidemi,Oze Isao,Nishida Yuichiro,Hara Megumi,Takashima Naoyuki,Turin TanvirChowdhury,Watanabe Miki,Suzuki Sadao,Ibusuki Rie,Shimoshikiryo Ippei,Nakamura Yohko,Mikami Haruo,Ikezaki Hiroaki,Furusyo Norihiro,Kuriki Kiyonori,Endoh Kaori,Koyama Teruhide,Matsui Daisuke,Uemura Hirokazu,Arisawa Kokichi,Sasakabe Tae,Okada Rieko,Kawai Sayo,Naito Mariko,Momozawa Yukihide,Kubo Michiaki,Wakai Kenji
American Journal of Nephrology 47(5), 304-316, 2018-06
… Results: In the discovery phase, 28 variants within 4 loci (chromosome [chr] 2 with 8 variants including rs3770636 in the LDL receptor related protein 2 gene locus, on chr 5 with 2 variants including rs270184, chr 17 with 15 variants including rs3785837 in the BCAS3 gene locus, and chr 18 with 3 variants including rs74183647 in the nuclear factor of activated T-cells 1 gene locus) reached the suggestive level of p < …
NAID 120006504382