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1. ベンゾジアゼピンの中毒および離脱benzodiazepine poisoning and withdrawal [show details]
…available worldwide. The high incidence of BZD overdose mirrors their widespread use and availability . The diagnosis and management of acute benzodiazepine poisoning will be reviewed here. A general approach …
2. ベンゾジアゼピン依存症：疫学、発症機序、臨床症状、経過、診断benzodiazepine use disorder epidemiology pathogenesis clinical manifestations course and diagnosis [show details]
…anterograde amnesia or the inability to create new memories). Benzodiazepine intoxication is reviewed separately. Signs of benzodiazepine overdose include nystagmus, stupor or coma, and respiratory depression …
3. 麻酔後回復室（PACU）における心血管の障害cardiovascular problems in the post anesthesia care unit pacu [show details]
4. 内容が不明の大量服薬をした危篤状態の成人の初期マネージメントinitial management of the critically ill adult with an unknown overdose [show details]
…mental status prior to intubation. Do not administer flumazenil for presumed or known benzodiazepine overdose, as the risk benefit ratio of this agent is poor and withdrawal seizures can develop . The…
5. 成人における薬物中毒への一般的アプローチgeneral approach to drug poisoning in adults [show details]
…morbidity. As an example, routine administration of flumazenil to comatose patients suspected of benzodiazepine overdose may precipitate seizures, particularly if a proconvulsant drug has also been ingested, and…

English Journal

The Effect of methylphenidate on Reed Scaling in Benzodiazepine Poisoning, A Prospective Trial.

Latifi-Pour M, Hassanian-Moghaddam H, Mortazavi HS, Shadnia S, Zamani N, Rahimi M.
Current clinical pharmacology. 2019 Jan;().
Benzodiazepine is one of the most important causes of substance abuse and intoxication throughout the world and Iran. The aim of our study was to determine the role of stimulants in reversing CNS level in acute Benzodiazepine poisoning patients who were hospitalized a referral poison center. This wa
PMID 30648520

Does high-dose benzodiazepine abuse really produce liver toxicity? Results from a series of 201 benzodiazepine monoabusers.

Lugoboni F, Mirijello A, Morbioli L, Arzenton E, Leone R, Faccini M, Casari R, De Cosmo S, Gasbarrini A, Addolorato G.
Expert opinion on drug safety. 2018 May;17(5)451-456.
Several side-effects related to prolonged benzodiazepines (BZD) use have been reported. Given the primary role of liver in BZD metabolism, toxicity related to prolonged high-dose BZD use could be conceivable. No data are available on the long-term impact of high-dose BZD use on liver. A total of 201
PMID 29621907

Patient emergency assessment following deliberate self-poisoning with benzodiazepines: Can cognitive markers predict recall of the psychiatric interview? A pilot study.

Salles J, Pariente J, Dimeglio C, Gandia P, Lemesle B, Giron A, Franchitto N, Schmitt L, Very E.
Journal of psychopharmacology (Oxford, England). 2017 10;31(10)1362-1368.
In cases of deliberate self-poisoning (DSP), patients often ingest benzodiazepines (BZDs), known to alter memory. Experts recommend recovery of the patient's cognitive capacity before psychiatric assessment. Unfortunately, there is no validated tool in common practice to assess whether sufficient co
PMID 28441901

Japanese Journal

迅速定量法(FPIA法)による急性ベンゾジアゼピン系薬物中毒における体内動態予測

平田清貴,松本宜明,黒川顕,猪熊朋子,松本光雄,村田正弘
病院薬学 = Journal of the Nippon Hospital Pharmacists Association 24(4), 349-356, 1998-08-10
… One of the important therapeutic indices in acute drug poisoning is the prediction of the drug's pharmacokinetic parameters. … However, there are few data available on the drugs concerning the pharmacokinetic parameters in acute drug poisoning which occurs when drugs are ingested in extremely large doses. …
NAID 110001799748

迅速定量法（ＦＰＩＡ法）による急性ベンゾジアゼピン系薬物中毒における体内動態予測

平田清貴,松本宜明,黒川顕,猪熊朋子,松本光雄,村田正弘
病院薬学 24(4), 349-356, 1998
… One of the important therapeutic indices in acute drug poisoning is the prediction of the drug's pharmacokinetic parameters. … However, there are few data available on the drugs concerning the pharmacokinetic parameters in acute drug poisoning which occurs when drugs are ingested in extremely large doses. …
NAID 130004299616

急性中毒における血清中ベンゾジアゼピン系薬物の定量

平田清貴,村田正弘,黒川顕,松本宜明,村松章子,松本光雄
病院薬学 = Journal of the Nippon Hospital Pharmacists Association 22(6), 572-578, 1996-12-10
… To determine benzodiazepines in the serum of patients with acute benzodiazepine (BZD) poisoning, a Fluorescence polarization immunoassay (FPIA) on Abbott's TDx analyzer system was performed. … The serum BZD (Flunitrazepam, Etizolam, Clotiazepam) concentrations were measured using benzodiazepine serum reagents. … The serums containing 100-2000 ng/ml of BZD were measured by means of FPIA. …
NAID 110001799615