ATP sulfurylase

ATPスルフリラーゼ

関

sulfate adenylyltransferase、sulfurylase

WordNet

1. the 1st letter of the Roman alphabet (同)a
2. the blood group whose red cells carry the A antigen (同)type_A, group A

PrepTutorEJDIC

1. answer / ampere

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/17 17:16:34」(JST)

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sulfate adenylyltransferase (ATP)
Identifiers
EC number	2.7.7.4
CAS number	9012-39-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

ATP-sulfurylase
crystal structure of atp sulfurylase from thermus thermophillus hb8 in complex with aps
Identifiers
Symbol	ATP-sulfurylase
Pfam	PF01747
InterPro	IPR002650
SCOP	1i2d
SUPERFAMILY	1i2d
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

In enzymology, a sulfate adenylyltransferase (EC 2.7.7.4) is an enzyme that catalyzes the chemical reaction

ATP + sulfate diphosphate + adenylyl sulfate

Thus, the two substrates of this enzyme are ATP and sulfate, whereas its two products are diphosphate and adenylyl sulfate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:sulfate adenylyltransferase. Other names in common use include adenosine-5'-triphosphate sulfurylase, adenosinetriphosphate sulfurylase, adenylylsulfate pyrophosphorylase, ATP sulfurylase, ATP-sulfurylase, and sulfurylase. This enzyme participates in 3 metabolic pathways: purine metabolism, selenoamino acid metabolism, and sulfur metabolism.

Some sulfate adenylyltransferases are part of a bifunctional polypeptide chain associated with adenosyl phosphosulfate (APS) kinase. Both enzymes are required for PAPS (phosphoadenosine-phosphosulfate) synthesis from inorganic sulfate.

Structural studies

As of late 2007, 18 structures have been solved for this class of enzymes, with PDB accession codes 1G8F, 1G8G, 1G8H, 1I2D, 1J70, 1JEC, 1JED, 1JEE, 1JHD, 1M8P, 1R6X, 1TV6, 1V47, 1X6V, 1XJQ, 1XNJ, 1ZUN, and 2GKS.

Applications

ATP sulfurylase is one of the enzymes used in pyrosequencing.

References

Further reading

• Bandurski RS, Wilson LG, Squires CL (1956). "The mechanism of "active sulfate" formation". J. Am. Chem. Soc. 78 (24): 6408–6409. doi:10.1021/ja01605a028. 
• Hilz H and Lipmann F (1955). "The enzymatic activation of sulfate". Proc. Natl. Acad. Sci. USA 41 (11): 880–890. doi:10.1073/pnas.41.11.880. 
• Venkatachalam KV, Akita H, Strott CA (1998). "Molecular cloning, expression, and characterization of human bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase and its functional domains". J. Biol. Chem. 273 (30): 19311–20. doi:10.1074/jbc.273.30.19311. PMID 9668121. 

This article incorporates text from the public domain Pfam and InterPro IPR002650

UpToDate Contents

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• 1. 高コレステロール血症の治療のためのATP IIIガイドライン atp iii guidelines for treatment of high blood cholesterol
• 2. 癌における悪液質の臨床的特徴および病因 clinical features and pathogenesis of cancer cachexia
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• 5. 糖尿病の治療におけるスルホニル尿素およびメグリチニド sulfonylureas and meglitinides in the treatment of diabetes mellitus

English Journal

• Use of the cysteine-repressible HpMET3 promoter as a novel tool to regulate gene expression in Hansenula polymorpha.

• Yoo SJ1, Chung SY, Lee DJ, Kim H, Cheon SA, Kang HA.
• Biotechnology letters.Biotechnol Lett.2015 Jul 14. [Epub ahead of print]
• OBJECTIVES: The promoter of HpMET3, encoding an ATP sulfurylase, was evaluated for its potential as a repressible promoter to downregulate the expression of target genes in the thermotolerant, methylotrophic yeast Hansenula polymorpha.RESULTS: The expression of lacZ under the control of the 0.6 kb
• PMID 26169200

• Expression of Critical Sulfur- and Iron-Oxidation Genes and the Community Dynamics During Bioleaching of Chalcopyrite Concentrate by Moderate Thermophiles.

• Zhou D1, Peng T, Zhou H, Liu X, Gu G, Chen M, Qiu G, Zeng W.
• Current microbiology.Curr Microbiol.2015 Jul;71(1):62-9. doi: 10.1007/s00284-015-0817-7. Epub 2015 May 5.
• Sulfate adenylyltransferase gene and 4Fe-4S ferredoxin gene are the key genes related to sulfur and iron oxidations during bioleaching system, respectively. In order to better understand the bioleaching and microorganism synergistic mechanism in chalcopyrite bioleaching by mixed culture of moderate
• PMID 25941022

• Real-time fluorescence assays of alkaline phosphatase and ATP sulfurylase activities based on a novel PPi fluorescent probe.

• Wang X1, Zhang Z1, Ma X1, Wen J1, Geng Z2, Wang Z3.
• Talanta.Talanta.2015 May;137:156-60. doi: 10.1016/j.talanta.2015.01.028. Epub 2015 Feb 2.
• An anthracene-armed tetraaza macrocyclic fluorescent probe 3-(9-anthrylmethyl)-3,6,9,15-tetraazabicyclo[9.3.1]pentadeca-1(15),11,13-triene(l) for detecting Zn(2+) in aqueous medium was synthesized. L-Zn(2+) complex, showed selectivity toward pyrophosphate ion (PPi) by quenching the fluorescence in a
• PMID 25770619

Japanese Journal

• Techniques : Kinetic Assays for Determining In Vitro APS Reductase Activity in Plants without the Use of Radioactive Substances

• Brychkova Galina,Yarmolinsky Dmitry,Sagi Moshe
• Plant and Cell Physiology 53(9), 1648-1658, 2012-09
• NAID 40019417526

• Development of a Homologous Transformation System for Aspergillus aculeatus Based on the sC Gene Encoding ATP-Sulfurylase

• ADACHI Hiromi,TANI Shuji,KANAMASA Shin,SUMITANI Jun-ichi,KAWAGUCHI Takashi
• Bioscience, biotechnology, and biochemistry 73(5), 1197-1199, 2009-05-23
• … A homologous transformation system was developed using the endogenous ATP-sulfurylase gene, AasC, as a selectable marker in Aspergillus aculeatus. … Molecular analysis of sC+ transformants revealed that the frequency of single copy integration at ATP-sulfurylase locus was more than 40%. …
• NAID 10027541507

Related Links

• ATP Sulfurylase (M0394) - New England Biolabs Japan

ニュー・イングランド・バイオラボ －NEBは制限酵素、エンドヌクレアーゼ、リコンビナント酵素、PCR用試薬、発現システム、マーカー、コンピテントセル、RNA研究用試薬、ポリメラーゼ、修飾酵素、核酸、細胞解析などの試薬 ...

• ATP Sulfurylase | New England Biolabs

Categories: Phosphatase & Sulfurylase Products Applications: DNA Sequencing Product Information Description Properties and Usage Quality Control Description ATP Sulfurylase catalyzes the activation of sulfate by transferring ...

Related Pictures

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★リンクテーブル★

リンク元	「sulfate adenylyltransferase」「ATPスルフリラーゼ」
関連記事	「AT」「ATP」「A」「sulfurylase」

「sulfate adenylyltransferase」

　　[★]

硫酸アデニルトランスフェラーゼ、硫酸アデニリルトランスフェラーゼ

関

ATP sulfurylase、sulfurylase

「ATPスルフリラーゼ」

　　[★]

英

ATP sulfurylase

関

スルフリラーゼ、硫酸アデニルトランスフェラーゼ

「AT」

　　[★]

• 無酸素性作業閾値 anaerobic threshold
• 毛細血管拡張性運動失調症 ataxia telangiectasia
• アンチトロンビン antithrombin
• 加速時間 acceleration time

「ATP」

　　[★] アデノシン三リン酸 アデノシン3リン酸 adenosine triphosphate adenosine 5'-triphosphate

「A」

　　[★]

• アデニン adenine
• アデノシン adenosine
• アラニン alanine

　 　 　

「sulfurylase」

　　[★]

スルフリラーゼ

関

ATP sulfurylase、sulfate adenylyltransferase