WordNet

(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A
informal term for information; "give me the gen on your new line of computers"

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1. アミロイド疾患の遺伝的要因 genetic factors in the amyloid diseases
2. アルツハイマー病の遺伝学 genetics of alzheimer disease
3. 成人における早期発症の認知症 early onset dementia in adults
4. アルツハイマー病の疫学、病理、および病因 epidemiology pathology and pathogenesis of alzheimer disease
5. 認知機能低下および認知症の危険因子 risk factors for cognitive decline and dementia

Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders.

Islam MT1,2.
Neurological research.Neurol Res.2017 Jan;39(1):73-82. Epub 2016 Nov 3.
Reactive species play an important role in physiological functions. Overproduction of reactive species, notably reactive oxygen (ROS) and nitrogen (RNS) species along with the failure of balance by the body's antioxidant enzyme systems results in destruction of cellular structures, lipids, proteins,
PMID 27809706

A First-in-Class Small-Molecule that Acts as a Dual Inhibitor of HDAC and PDE5 and that Rescues Hippocampal Synaptic Impairment in Alzheimer's Disease Mice.

Cuadrado-Tejedor M1,2, Garcia-Barroso C1, Sánchez-Arias JA3, Rabal O3, Pérez-González M1, Mederos S4, Ugarte A3, Franco R1,5, Segura V6, Perea G4, Oyarzabal J3, Garcia-Osta A1.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.Neuropsychopharmacology.2017 Jan;42(2):524-539. doi: 10.1038/npp.2016.163. Epub 2016 Aug 23.
The targeting of two independent but synergistic enzymatic activities, histone deacetylases (HDACs, class I and HDAC6) and phosphodiesterase 5 (PDE5), has recently been validated as a potentially novel therapeutic approach for Alzheimer's disease (AD). Here we report the discovery of a new first-in-
PMID 27550730

Curcumin attenuates paraquat-induced cell death in human neuroblastoma cells through modulating oxidative stress and autophagy.

Jaroonwitchawan T1, Chaicharoenaudomrung N1, Namkaew J1, Noisa P2.
Neuroscience letters.Neurosci Lett.2017 Jan 1;636:40-47. doi: 10.1016/j.neulet.2016.10.050. Epub 2016 Oct 26.
Paraquat is a neurotoxic agent, and oxidative stress plays an important role in neuronal cell death after paraquat exposure. In this study, we assessed the neuroprotective effect of curcumin against paraquat and explored the underlying mechanisms of curcumin in vitro. Curcumin treatment prevented pa
PMID 27793699

Hyperpolarization-activated cyclic nucleotide gated channels: a potential molecular link between epileptic seizures and Aβ generation in Alzheimer's disease

Saito Yuhki,Inoue Tsuyoshi,Zhu Gang,Kimura Naoki,Okada Motohiro,Nishimura Masaki,Kimura Nobuyuki,Murayama Shigeo,Kaneko Sunao,Shigemoto Ryuichi,Imoto Keiji,Suzuki Toshiharu
Molecular Neurodegeneration 7, 50, 2012-10-03
… Results: X11 and X11-like (X11L) gene knockout mice suffered from epileptic seizures, along with a malfunction of hyperpolarization-activated cyclic nucleotide gated (HCN) channels. … Conclusion: Because HCN1 associates with amyloid-β precursor protein (APP) and X11/X11L in the brain, genetic deficiency of X11/X11L may induce aberrant HCN1 distribution along with epilepsy. …
NAID 120005133364

American ginseng improves neurocognitive function in senescence-accelerated mice: Possible role of the upregulated insulin and choline acetyltransferase gene expression

Shi Shun,Shi Reika,Hashizume Kiyoshi
GERIATRICS & GERONTOLOGY INTERNATIONAL 12(1), 123-130, 2012-01
… Gene expressions of peroxisome proliferator-activated receptor delta (PPAR-d), insulin, choline acetyltransferase (ChAT) and amyloid precursor protein (APP) in the brain were measured by real-time quantitative reverse transcription polymerase chain reaction assays. … Gene upregulation of insulin and ChAT in the brain, but not of PPAR-d or APP, was evident in American ginseng-fed groups. …
NAID 120004754659