hepatic dysfunction

出典: meddic


hepatic damage, hepatic insufficiency, hepatopathy, impaired liver function, liver damage, liver disorder, liver dysfunction

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/04/17 06:23:00」(JST)

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英文文献

  • Underexpressed CNDP2 Participates in Gastric Cancer Growth Inhibition through Activating the MAPK Signaling Pathway.
  • Zhang Z1, Miao L2, Xin X3, Zhang J4, Yang S4, Miao M4, Kong X5, Jiao B4.Author information 1Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China Key Laboratory of Liver Disease, Center of Infectious Diseases, Guangzhou 458 Hospital, Guangzhou, China.2Department of Pharmacology, School of Pharmacy and Institute of Biomedical Sciences, Fudan University, Shanghai, China.3Department of Pharmacology, School of Pharmacy and Institute of Biomedical Sciences, Fudan University, Shanghai, China Department of Pharmacology, Taishan Medical University, Shandong Province, China.4Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China.5Key Laboratory of Liver Disease, Center of Infectious Diseases, Guangzhou 458 Hospital, Guangzhou, China.AbstractIncreasing evidence suggests that cytosolic non-specific dipeptidase 2 (CNDP2) appears to do more than just perform an enzymatic activity; it is functionally important in cancers as well. Here, we show that the expression of CNDP2 is commonly down-regulated in gastric cancer tissues. The ectopic expression of CNDP2 resulted in significant inhibition of cell proliferation, induction of cell apoptosis and cell cycle arrest, and suppressed gastric tumor growth in nude mice. We further revealed that the reintroduction of CNDP2 transcriptionally upregulated p38 and activated c-Jun NH2-terminal kinase (JNK), whereas the loss of CNDP2 increased the phosphorylation of extracellular signal-related kinase (ERK). These results suggest that CNDP2 acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway.
  • Molecular medicine (Cambridge, Mass.).Mol Med.2014 Dec 24;20(1):17-28. doi: 10.2119/molmed.2013.00102.
  • Increasing evidence suggests that cytosolic non-specific dipeptidase 2 (CNDP2) appears to do more than just perform an enzymatic activity; it is functionally important in cancers as well. Here, we show that the expression of CNDP2 is commonly down-regulated in gastric cancer tissues. The ectopic exp
  • PMID 24395568
  • Histopathology of fathead minnow (Pimephales promelas) exposed to hydroxylated fullerenes.
  • Jovanović B, Whitley EM, Palić D.Author information Chair for Fish Diseases and Fisheries Biology, Faculty of Veterinary Medicine, Ludwig Maximilians University of Munich (LMU) , Munich , Germany.AbstractHydroxylated fullerenes are reported to be very strong antioxidants, acting to quench reactive oxygen species, thus having strong potential for important and widespread applications in innovative therapies for a variety of disease processes. However, their potential for toxicological side effects is still largely controversial and unknown. Effects of hydroxylated fullerenes C60(OH)24 on the fathead minnow (Pimephales promelas) were investigated microscopically after a 72-hour (acute) exposure by intraperitoneal injection of 20 ppm of hydroxylated fullerenes per gram of body mass. Cumulative, semi-quantitative histopathologic evaluation of brain, liver, anterior kidney, posterior kidney, skin, coelom, gills and the vestibuloauditory system revealed significant differences between control and hydroxylated fullerene-treated fish. Fullerene-treated fish had much higher cumulative histopathology scores. Histopathologic changes included loss of cellularity in the interstitium of the kidney, a primary site of haematopoiesis in fish, and loss of intracytoplasmic glycogen in liver. In the coelom, variable numbers of leukocytes, including many macrophages and fewer heterophils and rodlet cells, were admixed with the nanomaterial. These findings raise concern about in vivo administration of hydroxylated fullerenes in experimental drugs and procedures in human medicine, and should be investigated in more detail.
  • Nanotoxicology.Nanotoxicology.2014 Nov;8(7):755-63. doi: 10.3109/17435390.2013.828794. Epub 2013 Aug 22.
  • Hydroxylated fullerenes are reported to be very strong antioxidants, acting to quench reactive oxygen species, thus having strong potential for important and widespread applications in innovative therapies for a variety of disease processes. However, their potential for toxicological side effects is
  • PMID 23883179
  • Hepatoprotective effects of fermented Curcuma longa L. on carbon tetrachloride-induced oxidative stress in rats.
  • Kim Y1, You Y2, Yoon HG3, Lee YH4, Kim K5, Lee J6, Kim MS7, Kim JC8, Jun W9.Author information 1Division of Food and Nutrition, Chonnam National University, Gwangju 550-757, Republic of Korea; Korea INS Pharm Research Institute, Jeollanamdo 519-822, Republic of Korea.2Human Ecology Research Institute, Chonnam National University, Gwangju 550-757, Republic of Korea.3Department of Biochemistry and Molecular Biology, College of Medicine, Yonsei University, Seoul 120-752, Republic of Korea.4Department of Food and Nutrition, University of Suwon, Suwon 445-743, Republic of Korea.5Department of Biofood Analysis, Korea Bio Polytechnic, Ganggyung 320-905, Republic of Korea.6Department of Medical Nutrition, Kyung Hee University, Yongin 446-701, Republic of Korea.7Department of Statistics, Chonnam National University, Gwangju 550-757, Republic of Korea.8College of Veterinary Medicine, Chonnam National University, Gwangju 550-757, Republic of Korea.9Division of Food and Nutrition, Chonnam National University, Gwangju 550-757, Republic of Korea; Human Ecology Research Institute, Chonnam National University, Gwangju 550-757, Republic of Korea. Electronic address: wjjin@chonnam.ac.kr.AbstractThe hepatoprotective effect of fermented Curcuma longa L. (FC) was investigated in rats under CCl4-induced oxidative stress. FC at a dose of 30 or 300mg/kg body weight (b.w.) was orally administered for 14days followed by a single dose of CCl4 (1.25mL/kg b.w. in 20% corn oil) on day 14. Pretreatment with FC drastically prevented the elevated activities of serum AST, ALT, LDH, and ALP caused by CCl4-induced hepatotoxicity. Histopathologically evident hepatic necrosis was significantly ameliorated by FC pretreatment. When compared to the CCl4-alone treated group, rats pretreated with FC displayed the reduced level of malondialdehyde. Furthermore, FC enhanced antioxidant capacities with higher activities of catalase, glutathione-S-transferase, glutathione reductase, and glutathione peroxidase, and level of reduced glutathione. These results suggest that FC could be a candidate used for the prevention against various liver diseases induced by oxidative stress via elevating antioxidative potentials and decreasing lipid peroxidation.
  • Food chemistry.Food Chem.2014 May 15;151:148-53. doi: 10.1016/j.foodchem.2013.11.058. Epub 2013 Nov 19.
  • The hepatoprotective effect of fermented Curcuma longa L. (FC) was investigated in rats under CCl4-induced oxidative stress. FC at a dose of 30 or 300mg/kg body weight (b.w.) was orally administered for 14days followed by a single dose of CCl4 (1.25mL/kg b.w. in 20% corn oil) on day 14. Pretreatment
  • PMID 24423514

和文文献

  • 症例報告 重症妊娠悪阻を契機に分娩まで遷延する肝機能障害を発症した1例
  • 桑原 知仁,川端 伊久乃,寺田 佳世子 [他]
  • 東京産科婦人科学会会誌 61(3), 396-401, 2012-10
  • NAID 40019492652
  • 症例報告 一過性の肝障害,高度脂肪肝及び膵腫大を呈し,画像経過を観察しえた劇症1型糖尿病の1例
  • 長尾 博文,岡田 拓也,鈴木 綾乃 [他]
  • 糖尿病 55(9), 722-726, 2012-09
  • NAID 40019452219
  • 臨床経験 プロポフォールとケタミンによる全静脈麻酔の腎機能に与える影響 : フェンタニルまたはレミフェンタニルを併用した場合の比較
  • 吉田 仁,工藤 倫之,澤田 匡宏 [他]
  • 麻酔 61(8), 794-799, 2012-08
  • NAID 40019402835

関連リンク

Hepatic dysfunction hepatic dyspepsia hepatic edema hepatic edema hepatic edema hepatic encephalopathy hepatic encephalopathy hepatic encephalopathy hepatic encephalopathy Hepatic encephalopathy clinical forms ...
Information about Hepatic dysfunction in the free online English dictionary and encyclopedia. Hepatic dysfunction - definition of Hepatic dysfunction by The Free Dictionary http://www.thefreedictionary.com/Hepatic+dysfunction ...

関連画像

Hepatic Dysfunction and Morphine opioids in renal or hepatic dysfunctionHepatic Dysfunction in Pediatric Scrub pneumophila. Renal and hepatic dysfunction Hepatic Dysfunction -jaundice (from liver  With Hepatic Dysfunction | ConsultantLive


★リンクテーブル★
リンク元肝機能障害」「liver damage」「hepatic damage」「liver disorder」「liver dysfunction
関連記事dysfunction」「hepatic

肝機能障害」

  [★]

liver dysfunction, hepatic dysfunction, impaired liver function
肝障害
[show details]


liver damage」

  [★]

hepatic damagehepatic dysfunctionhepatocellular damagehepatocellular injuryhepatopathyliver cell damageliver disorder

hepatic damage」

  [★]

hepatic dysfunctionhepatocellular damagehepatocellular injuryhepatopathyliver cell damageliver damageliver disorder

liver disorder」

  [★]

hepatic damagehepatic diseasehepatic dysfunctionhepatopathyliver damageliver disease


liver dysfunction」

  [★]

肝機能障害、肝機能異常、肝機能不全

hepatic dysfunctionhepatic insufficiencyimpaired liver functionliver disease


dysfunction」

  [★]

  • n.
  • vi
  • 機能不全に陥る
barrierdamagedifficultydisorderdisturbancefoefunctional disorderfunctional impairmenthindrancehypofunctionimpairimpairmentimpedimentincompetenceinsufficiencylesionmalfunctionobstaclestun

WordNet   license wordnet

「(medicine) any disturbance in the functioning of an organ or body part or a disturbance in the functioning of a social group; "erectile dysfunction"; "sexual relationship dysfunction"」
disfunction

PrepTutorEJDIC   license prepejdic

「機能障害,機能不全」


hepatic」

  [★]

  • adj.
  • 肝臓の、肝性の、肝の
hepatohepatogenicliver

WordNet   license wordnet

「pertaining to or affecting the liver; "hepatic ducts"; "hepatic cirrhosis"」

PrepTutorEJDIC   license prepejdic

「肝臓の;肝臓にきく,肝臓のような色の」




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