graft-versus-host disease

出典: meddic

移植片対宿主病 GVHD

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/08/28 15:12:57」(JST)

wiki en

[Wiki en表示]

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

英文文献

  • Endoscopy in the diagnosis of intestinal graft-versus-host disease: Is lower endoscopy with biopsy as effective in diagnosis as upper endoscopy combined with lower endoscopy?
  • Crowell KR, Patel RA, Fluchel M, Lowichik A, Bryson S, Pohl JF.SourceDepartment of Pediatrics, Primary Children's Medical Center, University of Utah, Salt Lake City, Utah.
  • Pediatric blood & cancer.Pediatr Blood Cancer.2013 Nov;60(11):1798-800. doi: 10.1002/pbc.24634. Epub 2013 Jun 14.
  • BACKGROUND: Graft-versus-host disease (GvHD) causes morbidity and mortality in recipients of hematopoietic stem cell transplantation (SCT). This study assessed the distribution of GvHD in gastrointestinal (GI) biopsies from the upper and lower GI tract in pediatric patients who had undergone SCT and
  • PMID 23775774
  • Feasibility of clofarabine cytoreduction followed by haploidentical hematopoietic stem cell transplantation in patients with relapsed or refractory advanced acute leukemia.
  • Tischer J, Stemmler HJ, Engel N, Hubmann M, Fritsch S, Prevalsek D, Schulz C, Zoellner AK, Bücklein V, Hill W, Ledderose G, Hausmann A.SourceDepartment of Medicine III, Hematopoietic stem cell transplantation, Ludwig-Maximilians University of Munich, Campus Grosshadern, Munich, Germany.
  • Annals of hematology.Ann Hematol.2013 Oct;92(10):1379-88. doi: 10.1007/s00277-013-1862-6. Epub 2013 Aug 9.
  • Clofarabine is a novel purine nucleoside analogue with immunosuppressive and anti-leukemic activity in acute lymphoblastic and myeloid leukemia (AML, ALL). This retrospective study was performed to evaluate the feasibility and anti-leukemic activity of a sequential therapy using clofarabine for cyto
  • PMID 23928857
  • Combination of fludarabine, amsacrine, and cytarabine followed by reduced-intensity conditioning and allogeneic hematopoietic stem cell transplantation in patients with high-risk acute myeloid leukemia.
  • Krejci M, Doubek M, Dusek J, Brychtova Y, Racil Z, Navratil M, Tomiska M, Horky O, Pospisilova S, Mayer J.SourceDepartment of Internal Medicine, Hematology and Oncology, University Hospital Brno and Masaryk University, Jihlavska 20, 625 00, Brno, Czech Republic, mkrejci@fnbrno.cz.
  • Annals of hematology.Ann Hematol.2013 Oct;92(10):1397-403. doi: 10.1007/s00277-013-1790-5. Epub 2013 Jun 1.
  • Sequential use of chemotherapy and reduced-intensity conditioning (RIC) with allogeneic stem cell transplantation (SCT) has been proposed to improve the treatment outcomes in patients with high-risk acute myeloid leukemia (AML). Here, we present our experience with this procedure in a cohort of 60 A
  • PMID 23728608

和文文献

  • 急性リンパ性白血病に合併した腸管嚢胞様気腫症の1例 : 血液疾患に合併する同症についての文献的考察を加えて
  • 塩崎 宏子,岡村 隆光,田嶋 強,石山 みどり,吉永 健太郎,志関 雅幸,森 直樹,寺村 正尚,泉二 登志子
  • 東京女子医科大学雑誌 83(E2), E638-E642, 2013-03-31
  • 急性リンパ性白血病に対する化学療法中に腸管嚢胞様気腫症(PCI)を合併した症例を経験したので、成人血液疾患に合併するPCIについて文献的考察を加えて報告した。症例は16歳男性。急性リンパ性白血病と診断され、化学療法により完全寛解を得たが、地固め療法中に腹痛と下痢を認め、腹部単純X線と腹部CTによりPCIと診断された。絶食、輸液、酸素吸入などの保存的治療によって改善した。当科において最初のPCI症例 …
  • NAID 110009575079
  • Comparison of direct costs for allogeneic bone marrow transplantation from unrelated donors and umbilical cord blood transplantation for childhood acute lymphoblastic leukemia in Japan
  • 羽賀 洋一,松本 邦愛,小原 明,佐地 勉,長谷川 友紀
  • 東邦医学会雑誌 60(2), 76-84, 2013-03-00
  • … 原著Background: The 5-year disease-free survival rate for childhood acute lymphoblastic leukemia has improved due to improvements in the regimen. … Seven adverse events associated with transplantation were analyzed: severe bacterial infection, severe fungal infection, cytomegalovirus infection, herpes virus infection, graft failure, sinusoidal obstruction syndrome, and acute graft-versus-host disease. …
  • NAID 120005306377
  • Chronic Graft-versus-Host Disease: Disease Biology and Novel Therapeutic Strategies
  • Nishimori Hisakazu,Maeda Yoshinobu,Tanimoto Mitsune
  • Acta Medica Okayama 67(1), 1-8, 2013-02-00
  • Graft-versus-host disease (GVHD) is a major complication after allogeneic hematopoietic stem cell transplantation. …
  • NAID 120005232331

関連リンク

Graft-versus-host disease (GVHD) is a complication that can occur after a stem cell or bone marrow transplant. With GVHD, the newly transplanted donor ... GVHD may occur after a bone marrow or stem cell transplant ...
Lymphocytes are white blood cells responsible for immune reactions, which can be dangerous in graft-versus-host (GVH) disease seen in bone marrow transplants but beneficial when the donor's immunity against infection is ...

関連画像

Graft versus host disease =داء رفض Figure 4 : Graft-versus-host disease Graft versus host disease =داء رفض Graft versus host disease =داء رفض Graft versus host disease =داء رفض  graft versus host disease in de diverse


★リンクテーブル★
先読みGVHD
リンク元移植片対宿主病
拡張検索chronic graft-versus-host disease」「post transfusion graft-versus-host disease」「acute graft-versus-host disease
関連記事graft」「host」「disease」「versus」「diseased

GVHD」

  [★] 移植片対宿主病 graft versus host disease


移植片対宿主病」

  [★]

graft versus host disease, graft-versus-host disease, GVHD
GVH病
GVH反応拒絶反応移植片対宿主反応
  • first aid step1 2006 p.191

概念

移植片 が 宿主 に対して 免疫反応を起こす
  • 皮膚(→紅斑)、肝臓(→黄疸)、小腸(→下痢)の障害が起こる

分類

発症時期

重症度

GVHDの臨床病期
Stage 皮膚 肝臓(ビリルビン) 消化管
+ 斑状丘疹 体表の25%以下 2-3 mg/dl 下痢 > 500 ml/day
++ 斑状丘疹 25-50% 3-6 mg/dl 下痢 > 1000 ml/day
+++ 全身紅皮症 50-75% 6-15 mg/dl 下痢 > 1500 ml/day
++++ 全身紅皮症 水疱, 落屑 >15 mg/dl 激しい腹痛and/orイレウス
GVHDの重症度
Grade 皮膚 肝/消化管 全身状態
I + ~ ++ - ~ - 問題なし
II + ~ +++ + and/or + 軽度の悪化
III ++ ~ +++ ++ ~ +++ and/or ++ ~ +++ 高度の悪化
IV ++ ~ ++++ ++ ~ ++++ and ++ ~ ++++ 極度の悪化


メモ

USMLE

  • Q book p.192 28



chronic graft-versus-host disease」

  [★]

chronic GVHD


post transfusion graft-versus-host disease」

  [★] 輸血後移植片対宿主病

acute graft-versus-host disease」

  [★]

急性移植片対宿主病

graft」

  [★]

  • n
  • v.
  • 移植する、(植物)接木する
cell transplantengraftengraftmentexplantgraftingimplantimplantationorgan graftorgan transplanttissue grafttissue transplanttransfertransplanttransplant recipienttransplantation

WordNet   license wordnet

「cause to grow together parts from different plants; "graft the cherry tree branch onto the plum tree"」
engraft, ingraft

WordNet   license wordnet

「the act of grafting something onto something else」
grafting

WordNet   license wordnet

「(surgery) tissue or organ transplanted from a donor to a recipient; in some cases the patient can be both donor and recipient」
transplant

PrepTutorEJDIC   license prepejdic

「(つぎ木の)つぎ穂;つぎ木 / (皮被・内臓・骨などの)移植片 / (木に)〈つぎ穂〉‘を'つぐ,(体に)〈移植片〉‘を'移植する《+『名』+『on』(『upon』,『in』,『into』)+『名』》 / …‘を'結合させる《+『名』+『together』》 / (…に)つぎ木する,移植する《+『on』(『upon』,『in』,『into』)+『名』》」

PrepTutorEJDIC   license prepejdic

「収賄,汚職;贈賄;〈C〉汚職で得たもの / 汚職する,収賄する」


host」

  [★]

WordNet   license wordnet

「be the host of or for; "We hosted 4 couples last night"」

WordNet   license wordnet

「an animal or plant that nourishes and supports a parasite; it does not benefit and is often harmed by the association」

WordNet   license wordnet

「the owner or manager of an inn」
innkeeper, boniface

WordNet   license wordnet

「archaic terms for army」
legion

WordNet   license wordnet

「(medicine) recipient of transplanted tissue or organ from a donor」

WordNet   license wordnet

「a person who invites guests to a social event (such as a party in his or her own home) and who is responsible for them while they are there」

WordNet   license wordnet

「any organization that provides resources and facilities for a function or event; "Atlanta was chosen to be host for the Olympic Games"」

PrepTutorEJDIC   license prepejdic

「(…の)大群,大勢《+『of』+『名』》(multitude)」

PrepTutorEJDIC   license prepejdic

「(客を接待する)『主人』,『主人役』;(…の)主人[役]《+『to』+『名』》 / (旅館の)主人 / 寄生動(植)物の宿主 / 〈晩餐会など〉‘の'主人役を務める,‘を'主催する」

disease」

  [★]

  • n.
疾患illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)
特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)
  • something that is very wrong with people's attitudes, way of life or with society.
ailailmentdisease entitydisorderillillnessmaladysicksickness
  • 注意
diseaseillnessdisorder


WordNet   license wordnet

「an impairment of health or a condition of abnormal functioning」

PrepTutorEJDIC   license prepejdic

「(体の)『病気』,疾患 / (精神・道徳などの)病気,病弊」

PrepTutorEJDIC   license prepejdic

「女性の話術芸人 =diseur」

versus」

  [★]

(ラテン語versus(vertere(回す、向ける)のpp)、「~に向けられた→~の方向に、~に対して」)
  • prep.
  • (訴訟・競技などで)~対、~に対して(against)(v.,vs.)
  • ~に対して、比較して
The first is the reliance on E-codes and ICD-9-CM codes for abuse to ascertain abusive versus accidental injuries.
pairpairedpairwisevs

PrepTutorEJDIC   license prepejdic

「(訴訟・競技などで)…対(《略》v.,vs.)(against) / (比較や二者択一において)…に対して」

diseased」

  [★]

WordNet   license wordnet

「caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes"」
morbid, pathologic, pathological

PrepTutorEJDIC   license prepejdic

「病気にかかった / 病的な,不健全な(morbid)」




★コメント★

[メモ入力エリア]
※コメント5000文字まで
ニックネーム:
コメント:




表示
個人用ツール


  meddic.jp

リンク
連絡