WordNet

street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"

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酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/19 10:31:20」(JST)

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Flufenamic acid is a member of the anthranilic acid derivatives (or fenamate) class of NSAID drugs^[1]^:718 Like other members of the class, it is a COX inhibitor and prevents formation of prostaglandins.^[2] Flufenamic acid is known to bind to and reduce the activity of prostaglandin F synthase and activate TRPC6.^[3]

It is not widely used in humans as it has a high rate (30-60%) of gastrointestinal side effects.^[4]^:310 It is generally not available in the US.^[2] It is available in some Asian and European countries as a generic.^[5]

Scientists led by Claude Winder from Parke-Davis invented flufenamic acid in 1963, along with fellow members of the class, mefenamic acid in 1961 and meclofenamate sodium in 1964.^[1]^:718

References

^ ^a ^b Whitehouse M. Drugs to Treat Inflammation: A Historical Overview. pp 707-729 in Frontiers in Medicinal Chemistry , Volume 4. Eds Rahman A, et al. Bentham Science Publishers, 2009 ISBN 9781608052073
^ ^a ^b NIH LiverTox Database Mefenamic Acid Last updated June 23, 2015. Page accessed July 3, 2015. Quote: "(fenamates generally not available in the United States, such as tolfenamic acid and flufenamic acid)"
^ "Chemical–Gene Interaction Query: Flufenamic Acid (Homo sapiens)". Comparative Toxicogenomics Database. North Carolina State University. Retrieved 4 July 2015.
^ Jeffrey K. Aronson. Meyler's Side Effects of Analgesics and Anti-inflammatory Drugs. Elsevier, 2009 ISBN 9780080932941
^ Drugs.com Drugs.com international listings for flufenamic acid Page accessed July 3, 2015

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UpToDate Contents

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1. 尿酸のバランス uric acid balance
2. 出産時の臍帯血酸塩基分析 umbilical cord blood acid base analysis at delivery
3. 妊娠中の葉酸補充 folic acid supplementation in pregnancy
4. ポルフィリン症：概要 porphyrias an overview
5. 疾患予防におけるビタミン補給 vitamin supplementation in disease prevention

English Journal

TRPM2 contributes to antigen-stimulated Ca(2+) influx in mucosal mast cells.

Oda S, Uchida K, Wang X, Lee J, Shimada Y, Tominaga M, Kadowaki M.SourceDivision of Gastrointestinal Pathophysiology, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama, 930-0194, Japan.
Pflugers Archiv : European journal of physiology.Pflugers Arch.2013 Jan 31. [Epub ahead of print]
Food allergy (FA) is a common allergic disease without any currently available effective drug therapies. Mucosal mast cells (MMCs) play a particularly important role in FA, and the increase in their cytosolic Ca(2+) concentration ([Ca(2+)](cyt)) is considered to be a principal component of the degra
PMID 23371039

Finite dose skin mass balance including the lateral part: comparison between experiment, pharmacokinetic modeling and diffusion models.

Selzer D, Hahn T, Naegel A, Heisig M, Kostka KH, Lehr CM, Neumann D, Schaefer UF, Wittum G.SourceBiopharmaceutics and Pharmaceutical Technology, Saarland University, Saarbruecken, Germany.
Journal of controlled release : official journal of the Controlled Release Society.J Control Release.2013 Jan 28;165(2):119-28. doi: 10.1016/j.jconrel.2012.10.009. Epub 2012 Oct 22.
This work investigates in vitro finite dose skin absorption of the model compounds flufenamic acid and caffeine experimentally and mathematically. The mass balance in different skin compartments (donor, stratum corneum (SC), deeper skin layers (DSL), lateral skin parts and acceptor) is analyzed as a
PMID 23099116

Bicellar systems as new delivery strategy for topical application of flufenamic acid.

Rubio L, Alonso C, Rodríguez G, Cócera M, López-Iglesias C, Coderch L, De la Maza A, Parra JL, López O.SourceDepartment of Chemical and Surfactants Technology (IQAC-CSIC), C/Jordi Girona 18-26, 08034 Barcelona, Spain. Electronic address: laia.rubio@iqac.csic.es.
International journal of pharmaceutics.Int J Pharm.2013 Jan 26. pii: S0378-5173(13)00065-3. doi: 10.1016/j.ijpharm.2013.01.034. [Epub ahead of print]
In this work, bicellar systems, bilayered disc-shaped nanoaggregates formed in water by phospholipids, are proposed as a novel strategy for delivery of the anti-inflammatory flufenamic acid (FFA) to the skin. A comparative percutaneous penetration study of this drug in bicellar systems and other veh
PMID 23357252

Japanese Journal

Effect of N-Phenylanthranilic Acid Scaffold Nonsteroidal Anti-inflammatory Drugs on the Mitochondrial Permeability Transition

Biological and Pharmaceutical Bulletin 39(2), 278-284, 2016
NAID 130005122365

TRPM4 Channels Mediate Hypertonicity-induced, Ca²⁺-impermeable, Non-selective Cation Currents in a Cervical Cancer Cell Line, HeLa Cells

信州医学雑誌 62(1), 33-44, 2014
NAID 130004551913

Wing (Ib) cells in frog taste discs detect dietary unsaturated fatty acids

Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology 166(3), 434-440, 2013-11
NAID 120005328272

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★リンクテーブル★

リンク元	「フルフェナム酸」「flufenamate」
拡張検索	「flufenamic acid aluminum」「flufenamic acid aluminium」

「フルフェナム酸」

Flufenamic acid
Systematic (IUPAC) name
	2-{[3-(Trifluoromethyl)phenyl]amino}benzoic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of; administration	oral, topical
Legal status
Legal status	AU: S4 (Prescription only);
Pharmacokinetic data
Protein binding	extensively
Metabolism	Hydroxylation, glucuronidation
Biological half-life	~3 h
Excretion	50% urine, 36% feces
Identifiers
CAS Number	530-78-9
ATC code	M01AG03 (WHO)
PubChem	CID 3371
IUPHAR/BPS	2447
DrugBank	DB02266
ChemSpider	3254
UNII	60GCX7Y6BH
KEGG	D01581
ChEBI	CHEBI:42638
ChEMBL	CHEMBL23588
Chemical data
Formula	C14H10F3NO2
Molar mass	281.22991 g/mol
	SMILES FC(F)(F)c1cc(ccc1)Nc2ccccc2C(=O)O ;
	InChI InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20) ; Key:LPEPZBJOKDYZAD-UHFFFAOYSA-N ;
Physical data
Melting point	124 to 125 °C (255 to 257 °F) resolidification and remelting at 134°C to 136°C
Solubility in water	Practically insoluble in water; soluble in ethanol, chloroform and diethyl ether mg/mL (20 °C)
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