factor VII

出典: meddic

第VII因子

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/10/27 05:56:09」(JST)

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英文文献

  • Antimicrobial responses of teleost phagocytes and innate immune evasion strategies of intracellular bacteria.
  • Grayfer L1, Hodgkinson JW2, Belosevic M3.Author information 1Department of Microbiology and Immunology, University of Rochester, Rochester, NY, USA.2Department of Biological Sciences, University of Alberta, Edmonton, Canada.3Department of Biological Sciences, University of Alberta, Edmonton, Canada; School of Public Health, University of Alberta, Edmonton, Canada. Electronic address: mike.belosevic@ualberta.ca.AbstractDuring infection, macrophage lineage cells eliminate infiltrating pathogens through a battery of antimicrobial responses, where the efficacy of these innate immune responses is pivotal to immunological outcomes. Not surprisingly, many intracellular pathogens have evolved mechanisms to overcome macrophage defenses, using these immune cells as residences and dissemination strategies. With pathogenic infections causing increasing detriments to both aquacultural and wild fish populations, it is imperative to garner greater understanding of fish phagocyte antimicrobial responses and the mechanisms by which aquatic pathogens are able to overcome these teleost macrophage barriers. Insights into the regulation of macrophage immunity of bony fish species will lend to the development of more effective aquacultural prophylaxis as well as broadening our understanding of the evolution of these immune processes. Accordingly, this review focuses on recent advances in the understanding of teleost macrophage antimicrobial responses and the strategies by which intracellular fish pathogens are able to avoid being killed by phagocytes, with a focus on Mycobacterium marinum.
  • Developmental and comparative immunology.Dev Comp Immunol.2014 Apr;43(2):223-42. doi: 10.1016/j.dci.2013.08.003. Epub 2013 Aug 15.
  • During infection, macrophage lineage cells eliminate infiltrating pathogens through a battery of antimicrobial responses, where the efficacy of these innate immune responses is pivotal to immunological outcomes. Not surprisingly, many intracellular pathogens have evolved mechanisms to overcome macro
  • PMID 23954721
  • Natriuretic peptides modulate ATP-sensitive K(+) channels in rat ventricular cardiomyocytes.
  • Burley DS, Cox CD, Zhang J, Wann KT, Baxter GF.Author information Cardiff School of Pharmacy and Pharmaceutical Sciences, Cardiff University, King Edward VII Avenue, Cardiff, CF10 3NB, UK, burleyds@cardiff.ac.uk.AbstractB-type natriuretic peptide (BNP) and C-type natriuretic peptide (CNP), and (Cys-18)-atrial natriuretic factor (4-23) amide (C-ANF), are cytoprotective under conditions of ischemia-reperfusion, limiting infarct size. ATP-sensitive K(+) channel (KATP) opening is also cardioprotective, and although the KATP activation is implicated in the regulation of cardiac natriuretic peptide release, no studies have directly examined the effects of natriuretic peptides on cardiac KATP activity. Normoxic cardiomyocytes were patch clamped in the cell-attached configuration to examine sarcolemmal KATP (sKATP) activity. The KATP opener pinacidil (200 μM) increased the open probability of the patch (NPo; values normalized to control) at least twofold above basal value, and this effect was abolished by HMR1098 10 μM, a selective KATP blocker (5.23 ± 1.20 versus 0.89 ± 0.18; P < 0.001). We then examined the effects of BNP, CNP, C-ANF and 8Br-cGMP on the sKATP current. Bath application of BNP (≥10 nM) or CNP (≥0.01 nM) suppressed basal NPo (BNP: 1.00 versus 0.56 ± 0.09 at 10 nM, P < 0.001; CNP: 1.0 versus 0.45 ± 0.16, at 0.01 nM, P < 0.05) and also abolished the pinacidil-activated current at concentrations ≥10 nM. C-ANF (≥10 nM) enhanced KATP activity (1.00 versus 3.85 ± 1.13, at 100 nM, P < 0.05). The cGMP analog 8Br-cGMP 10 nM dampened the pinacidil-activated current (2.92 ± 0.60 versus 1.53 ± 0.32; P < 0.05). Natriuretic peptides modulate sKATP current in ventricular cardiomyocytes. This may be at least partially associated with their ability to augment intracellular cGMP concentrations via NPR-A/B, or their ability to bind NPR-C with high affinity. Although the mechanism of modulation requires elucidation, these preliminary data give new insights into the relationship between natriuretic peptide signaling and sKATP in the myocardium.
  • Basic research in cardiology.Basic Res Cardiol.2014 Mar;109(2):402. doi: 10.1007/s00395-014-0402-4. Epub 2014 Jan 30.
  • B-type natriuretic peptide (BNP) and C-type natriuretic peptide (CNP), and (Cys-18)-atrial natriuretic factor (4-23) amide (C-ANF), are cytoprotective under conditions of ischemia-reperfusion, limiting infarct size. ATP-sensitive K(+) channel (KATP) opening is also cardioprotective, and although the
  • PMID 24477916
  • Plasma Levels and Distribution of Gene Polymorphisms of Factor VII in Turkish Population.
  • Turfan M, Poyraz F, Kaymak AÖ, Ergun MA, Tavil Y, Gursel T, Abaci A.Author information 1Department of Cardiology, Bezmialem University, Istanbul, Turkey.AbstractThree factor VII (FVII) promoter haplotypes are associated with stratified plasma FVII levels. To our knowledge, this is the first study examining the distribution of FVII gene polymorphism and levels in Turkish population. The study population was classified into 3 groups according to the absence of coronary arterial disease and presence or absence of a history of myocardial infarction. It was found that the levels of FVII coagulant activity (FVIIc) were higher in the event group than that of the other groups. Participants with high FVIIc levels were found to have 2-fold increased risk for myocardial infarction. The alleles at the FVII loci in all cases are similar. In conclusion, our results indicate that FVIIc levels have an important predictive role in cardiovascular events. The distribution of FVII gene polymorphisms in the Turkish population shows significant differences when compared with European populations.
  • Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis.Clin Appl Thromb Hemost.2014 Mar;20(2):164-8. doi: 10.1177/1076029612459676. Epub 2012 Sep 9.
  • Three factor VII (FVII) promoter haplotypes are associated with stratified plasma FVII levels. To our knowledge, this is the first study examining the distribution of FVII gene polymorphism and levels in Turkish population. The study population was classified into 3 groups according to the absence o
  • PMID 22964781

和文文献

  • 肉眼的血尿, 前立腺生検後の皮下出血を契機に診断された後天性血友病の1例
  • 木村 博子,植垣 正幸,青山 輝義,三好 隆史,永井 謙一,橋村 孝幸
  • 泌尿器科紀要 59(5), 305-308, 2013-05-00
  • … Acquired hemophilia is a rare disease that can result in life threatening bleeding associated with coagulation factor VIII inhibitors. … Further hematological evaluation showed the presence of coagulation factor VIII inhibitors, which led to the diagnosis of acquired hemophilia. … All symptoms disappeared without complication after administration of predonisolone and recombinant activated factor VII. …
  • NAID 120005245082
  • 測定試薬変更時のプロトロンビン時間(PT)のデータ乖離に関する検討-先天性第VII因子欠乏症における乖離を経験して-
  • 大塚 洋子/坂口 裕子/坂本 輝彦/山田 理恵子/川内 喜代隆/加藤 博之
  • 東京女子医科大学雑誌 83(2), 72-78, 2013-04-25
  • … 【緒言】PTの測定において、試薬の変更により凝固時間(PT-s)が大きく延長したが、PT-INRが減少した先天性第VII因子欠乏症症例を経験した.このデータ乖離の原因検索を行ったので報告する.【対象と方法】対象として凝固第VII因子欠乏症症例とPT 測定依頼のあった203例の血漿および第VII因子欠乏血漿で作製した希釈検体を用いた。 …
  • NAID 110009581133
  • 後天性血友病A:第VIII因子インヒビター
  • 森 直樹
  • 東京女子医科大学雑誌 83(E2), E508-E511, 2013-03-31
  • … ,治療としては、急性出血に対して抗体価が低力価の場合第VIII因子製剤を投与するが、無効例や抗体価が低力価でない場合には、活性化プロトロンビン複合体製剤、遺伝子組換え活性型第VII因子製剤によるバイパス療法が行われる。 …
  • NAID 110009575060

関連リンク

Factor VII (formerly known as proconvertin) is one of the proteins that causes blood to clot in the coagulation cascade. It is an enzyme (EC 3.4.21.21) of the serine protease class. A recombinant form of human factor VIIa (NovoSeven, eptacog ...

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★リンクテーブル★
リンク元第VII因子」「stable factor」「coagulation factor VII
拡張検索factor VIII deficiency」「coagulation factor VIII」「blood coagulation factor VII
関連記事factor」「fact」「V」「VI

第VII因子」

  [★]

factor VII, FVII, F VII
血清プロトロンビン転化促進因子 serum prothrombin conversion accelerator SPCAプロコンバーチン proconvertin安定因子 stable factorオートトロンビンI autothrombin Iコトロンボプラスチン cothromboplastin因子VII
血液凝固因子



  • 外因系



stable factor」

  [★] 第VII因子安定因子

blood coagulation factor VIIcoagulation factor VIIfactor VII、coagulation factors, factor VII

coagulation factor VII」

  [★]

blood coagulation factor VIIfactor VIIstable factor

factor VIII deficiency」

  [★]

第VIII因子欠乏症第VIII因子欠損症

haemophiliahemophiliahemophilia A


coagulation factor VIII」

  [★]

antihemophilic factorblood coagulation factor VIIIfactor VIII


blood coagulation factor VII」

  [★]

coagulation factor VIIfactor VIIstable factor


factor」

  [★]

  • n.
elementelementaryfactorialparameter

WordNet   license wordnet

「be a contributing factor; "make things factor into a company''s profitability"」

WordNet   license wordnet

「any of the numbers (or symbols) that form a product when multiplied together」

WordNet   license wordnet

「an independent variable in statistics」

WordNet   license wordnet

「anything that contributes causally to a result; "a number of factors determined the outcome"」

PrepTutorEJDIC   license prepejdic

「(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize」

WordNet   license wordnet

「consider as relevant when making a decision; "You must factor in the recent developments"」
factor in, factor out

WordNet   license wordnet

「resolve into factors; "a quantum computer can factor the number 15"」
factor in, factor out

fact」

  [★]

  • n.
actualactuallyin factin practiceindeedpractically

WordNet   license wordnet

「an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"」

WordNet   license wordnet

「a concept whose truth can be proved; "scientific hypotheses are not facts"」

WordNet   license wordnet

「a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"」

WordNet   license wordnet

「a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"」

PrepTutorEJDIC   license prepejdic

「〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行」

V」

  [★]

WordNet   license wordnet

「the 22nd letter of the Roman alphabet」
v

PrepTutorEJDIC   license prepejdic

「vanadium の化学記号」

VI」

  [★]

PrepTutorEJDIC   license prepejdic

「Virgin Islands」



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