WordNet

an impairment of health or a condition of abnormal functioning
the act of tolerating something
the power or capacity of an organism to tolerate unfavorable environmental conditions
willingness to recognize and respect the beliefs or practices of others
caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological

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Circular dichroism and electron microscopy studies in vitro of 33-mer gliadin peptide revealed secondary structure transition and supramolecular organization.

Herrera MG, Zamarreño F, Costabel M, Ritacco H, Hütten A, Sewald N, Dodero VI.SourceDepartment of Chemistry, INQUISUR, National University of South, CONICET, Av. Alem 1253, 8000 Bahía Blanca, Argentina.
Biopolymers.Biopolymers.2014 Jan;101(1):96-106. doi: 10.1002/bip.22288.
Gliadin, a protein present in wheat, rye, and barley, undergoes incomplete enzymatic degradation during digestion, producing an immunogenic 33-mer peptide, LQLQPF(PQPQLPY)3 PQPQPF. The special features of 33-mer that provoke a break in its tolerance leading to gliadin sensitivity and celiac disease
PMID 23703327

Pucino V, De Rosa V, Procaccini C, Matarese G.SourceDivisione di Immunologia Clinica ed Allergologia, Centro Interdipartimentale di Ricerca in Scienze Immunologiche di Base e Cliniche, Università di Napoli Federico II, Napoli, Italy.
Chemical immunology and allergy.Chem Immunol Allergy.2014;99:155-69. doi: 10.1159/000353557. Epub 2013 Oct 17.
Regulatory T cells (Treg cells) are crucial in mediating immune homeostasis and promoting the establishment and maintenance of peripheral tolerance. Excess body weight and obesity are typified by 'low-degree' chronic inflammation and are associated with an increased risk of atherosclerosis, diabetes
PMID 24217608

Drug-Induced Hypothermia as Beneficial Treatment before and after Cerebral Ischemia.

Johansen FF, Hasseldam H, Rasmussen RS, Bisgaard AS, Bonfils PK, Poulsen SS, Hansen-Schwartz J.SourceMolecular Pathology, Biotech Research and Innovation Centre, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Pathobiology : journal of immunopathology, molecular and cellular biology.Pathobiology.2014;81(1):42-52. doi: 10.1159/000352026. Epub 2013 Aug 23.
Objectives: Hypothermia is still unproven as beneficial treatment in human stroke, although in animal models, conditioning the brain with hypothermia has induced tolerance to insults. Here, we delineate the feasibility of drug-induced mild hypothermia in reducing ischemic brain damage when condition
PMID 23989388

Liver steatosis is associated with insulin resistance in skeletal muscle rather than in the liver in Japanese patients with non-alcoholic fatty liver disease

Kato Ken-ichiro,Takeshita Yumie,Misu Hirofumi,Zen Yoh,Kaneko Shuichi,Takamura Toshinari
Journal of Diabetes Investigation 6(2), 158-163, 2015-03-01
… Aims/Introduction: To examine the association between liver histological features and organ-specific insulin resistance indices calculated from 75-g oral glucose tolerance test data in patients with non-alcoholic fatty liver disease. … Materials and Methods: Liver biopsy specimens were obtained from 72 patients with non-alcoholic fatty liver disease, and were scored for steatosis, grade and stage. …
NAID 120005593987

Intestinal Immunity and Gut Microbiota as Therapeutic Targets for Preventing Atherosclerotic Cardiovascular Diseases

Yamashita Tomoya,Kasahara Kazuyuki,Emoto Takuo,Matsumoto Takuya,Mizoguchi Taiji,Kitano Naoki,Sasaki Naoto,Hirata Ken-ichi
Circulation Journal advpub(0), 2015
… Atherosclerosis is considered a chronic inflammatory disease and an intervention targeting the inflammatory process could be a new therapeutic strategy for preventing atherosclerotic cardiovascular diseases (CVD). … Similar to regulatory immune responses achieved by oral tolerance, our method had systemic effects that ultimately contributed towards atherosclerosis reduction. …
NAID 130005089384

Atheroma Progression in Obese Early-stage Diabetic Japanese Patients in Response to Glycemic Control: Sub-analysis from the DIANA Study

Kataoka Yu,Yasuda Satoshi,Miyamoto Yoshihiro,Sase Kazuhiro,Kosuge Masami,Kimura Kazuo,Yoshimasa Yasunao,Miyazaki Shunichi,DIANA study investigators
Journal of Atherosclerosis and Thrombosis 22(7), 697-705, 2015
… We herein investigated the characteristics of the disease substrate in obese early-stage diabetics.Methods: The DIANA (DIAbetes and diffuse coronary NArrowing) study was a serial evaluation of angiographic disease progression in early-stage diabetics with coronary artery disease. … On serial angiographic evaluations, obese patients had greater disease progression, reflected by a larger percent change in the TLL (24.7±13.7 vs. 7.4±10.0%, p=0.04). …
NAID 130005089131