dimethyl sulfoxide

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ジメチルスルホキシド

dimethyl sulphoxidedimethylsulfoxideDMSO

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/06/09 02:28:56」(JST)

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英文文献

  • Fluorescence spectroscopy of Rhodamine 6G: Concentration and solvent effects.
  • Zehentbauer FM1, Moretto C1, Stephen R1, Thevar T1, Gilchrist JR2, Pokrajac D1, Richard KL3, Kiefer J4.Author information 1School of Engineering, University of Aberdeen, Fraser Noble Building, Aberdeen AB24 3UE, Scotland, United Kingdom.2Gilden Photonics, 9 South Avenue, Clydebank Business Park, Clydebank G81 2NR, Scotland, United Kingdom.3Magdalen College School, Oxford, United Kingdom.4School of Engineering, University of Aberdeen, Fraser Noble Building, Aberdeen AB24 3UE, Scotland, United Kingdom; Erlangen Graduate School in Advanced Optical Technologies, University of Erlangen-Nuremberg, 91052 Erlangen, Germany. Electronic address: j.kiefer@abdn.ac.uk.AbstractRhodamine 6G (R6G), also known as Rhodamine 590, is one of the most frequently used dyes for application in dye lasers and as a fluorescence tracer, e.g., in the area of environmental hydraulics. Knowing the spectroscopic characteristics of the optical emission is key to obtaining high conversion efficiency and measurement accuracy, respectively. In this work, solvent and concentration effects are studied. A series of eight different organic solvents (methanol, ethanol, n-propanol, iso-propanol, n-butanol, n-pentanol, acetone, and dimethyl sulfoxide (DMSO)) are investigated at constant dye concentration. Relatively small changes of the fluorescence spectrum are observed for the different solvents; the highest fluorescence intensity is observed for methanol and lowest for DMSO. The shortest peak wavelength is found in methanol (568nm) and the longest in DMSO (579nm). Concentration effects in aqueous R6G solutions are studied over the full concentration range from the solubility limit to highly dilute states. Changing the dye concentration provides tunability between ∼550nm in the dilute case and ∼620nm at high concentration, at which point the fluorescence spectrum indicates the formation of R6G aggregates.
  • Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.Spectrochim Acta A Mol Biomol Spectrosc.2014 Mar 5;121:147-51. doi: 10.1016/j.saa.2013.10.062. Epub 2013 Oct 25.
  • Rhodamine 6G (R6G), also known as Rhodamine 590, is one of the most frequently used dyes for application in dye lasers and as a fluorescence tracer, e.g., in the area of environmental hydraulics. Knowing the spectroscopic characteristics of the optical emission is key to obtaining high conversion ef
  • PMID 24239710
  • Luteolin sensitizes the antiproliferative effect of interferon α/β by activation of Janus kinase/signal transducer and activator of transcription pathway signaling through protein kinase A-mediated inhibition of protein tyrosine phosphatase SHP-2 in cancer cells.
  • Tai Z1, Lin Y2, He Y1, Huang J1, Guo J1, Yang L1, Zhang G3, Wang F4.Author information 1Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China.2Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China; Key Laboratory of Bio-resources and Eco-environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu, China.3Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China; Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China. Electronic address: zhanggl@cib.ac.cn.4Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China; Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China. Electronic address: wangfei@cib.ac.cn.AbstractNew negative regulators of interferon (IFN) signaling, preferably with tissue specificity, are needed to develop therapeutic means to enhance the efficacy of type I IFNs (IFN-α/β) and reduce their side effects. We conducted cell-based screening for IFN signaling enhancer and discovered that luteolin, a natural flavonoid, sensitized the antiproliferative effect of IFN-α in hepatoma HepG2 cells and cervical carcinoma HeLa cells. Luteolin promoted IFN-β-induced Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway activation by enhancing the phosphorylation of Jak1, Tyk2, and STAT1/2, thereby promoting STAT1 accumulation in the nucleus and endogenous IFN-α-regulated gene expression. Of interest, inhibition of phosphodiesterase (PDE) abolished the effect of IFN-β and luteolin on STAT1 phosphorylation. Luteolin also increased the cAMP-degrading activity of PDE bound with type I interferon receptor 2 (IFNAR2) and decreased the intracellular cAMP level, indicating that luteolin may act on the JAK/STAT pathway via PDE. Protein kinase A (PKA) was found to negatively regulate IFN-β-induced JAK/STAT signaling, and its inhibitory effect was counteracted by luteolin. Pull-down and immunoprecipitation assays revealed that type II PKA interacted with IFNAR2 via the receptor for activated C-kinase 1 (RACK-1), and such interaction was inhibited by luteolin. Src homology domain 2 containing tyrosine phosphatase-2 (SHP-2) was further found to mediate the inhibitory effect of PKA on the JAK/STAT pathway. These data suggest that PKA/PDE-mediated cAMP signaling, integrated by RACK-1 to IFNAR2, may negatively regulate IFN signaling through SHP-2. Inhibition of this signaling may provide a new way to sensitize the efficacy of IFN-α/β.
  • Cellular signalling.Cell Signal.2014 Mar;26(3):619-28. doi: 10.1016/j.cellsig.2013.11.039. Epub 2013 Dec 12.
  • New negative regulators of interferon (IFN) signaling, preferably with tissue specificity, are needed to develop therapeutic means to enhance the efficacy of type I IFNs (IFN-α/β) and reduce their side effects. We conducted cell-based screening for IFN signaling enhancer and discovered that luteol
  • PMID 24333668
  • Toxicity and intracellular accumulation of bile acids in sandwich-cultured rat hepatocytes: Role of glycine conjugates.
  • Chatterjee S1, Bijsmans IT2, van Mil SW3, Augustijns P4, Annaert P5.Author information 1KU Leuven Department of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, O&N2, Herestraat 49 - Bus 921, 3000 Leuven, Belgium. Electronic address: Sagnik.Chatterjee@pharm.kuleuven.be.2Department of Metabolic Diseases, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: i.bijsmans@umcutrecht.nl.3Department of Metabolic Diseases, University Medical Center Utrecht, Utrecht, The Netherlands. Electronic address: s.w.c.vanmil@umcutrecht.nl.4KU Leuven Department of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, O&N2, Herestraat 49 - Bus 921, 3000 Leuven, Belgium. Electronic address: Patrick.Augustijns@pharm.kuleuven.be.5KU Leuven Department of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, O&N2, Herestraat 49 - Bus 921, 3000 Leuven, Belgium. Electronic address: Pieter.Annaert@pharm.kuleuven.be.AbstractExcessive intrahepatic accumulation of bile acids (BAs) is a key mechanism underlying cholestasis. The aim of this study was to quantitatively explore the relationship between cytotoxicity of BAs and their intracellular accumulation in sandwich-cultured rat hepatocytes (SCRH). Following exposure of SCRH (on day-1 after seeding) to various BAs for 24h, glycine-conjugated BAs were most potent in exerting toxicity. Moreover, unconjugated BAs showed significantly higher toxicity in day-1 compared to day-3 SCRH. When day-1/-3 SCRH were exposed (0.5-4h) to 5-100μM (C)DCA, intracellular levels of unconjugated (C)DCA were similar, while intracellular levels of glycine conjugates were up to 4-fold lower in day-3 compared to day-1 SCRH. Sinusoidal efflux was by far the predominant efflux pathway of conjugated BAs both in day-1 and day-3 SCRH, while canalicular BA efflux showed substantial interbatch variability. After 4h exposure to (C)DCA, intracellular glycine conjugate levels were at least 10-fold higher than taurine conjugate levels. Taken together, reduced BA conjugate formation in day-3 SCRH results in lower intracellular glycine conjugate concentrations, explaining decreased toxicity of (C)DCA in day-3 versus day-1 SCRH. Our data provide for the first time a direct link between BA toxicity and glycine conjugate exposure in SCRH.
  • Toxicology in vitro : an international journal published in association with BIBRA.Toxicol In Vitro.2014 Mar;28(2):218-30. doi: 10.1016/j.tiv.2013.10.020. Epub 2013 Nov 7.
  • Excessive intrahepatic accumulation of bile acids (BAs) is a key mechanism underlying cholestasis. The aim of this study was to quantitatively explore the relationship between cytotoxicity of BAs and their intracellular accumulation in sandwich-cultured rat hepatocytes (SCRH). Following exposure of
  • PMID 24211540

和文文献

  • Surface morphology of fluorene thin film fabricated by electrospray deposition technique using two organic solvents: Application for organic light-emitting diodes
  • 福田 武司,本多 善太郎,鎌田 憲彦
  • Thin Solid Films 520(1), 600-605, 2011-10
  • … The root mean square (RMS) roughness of the F8BT thin film was reduced by the addition of dimethyl sulfoxide (DMSO) in tetrahydrofuran (THF). …
  • NAID 120003459945
  • Lipase-catalyzed synthesis of hydrophobically modified dextrans : Activity and regioselectivity of lipase from Candida rugosa(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)
  • Kaewprapan Kultida,Wongkongkatep Jirarut,Panbangred Watanalai,Phinyocheep Pranee,Marie Emmanuelle,Durand Alain,Inprakhon Pranee
  • Journal of bioscience and bioengineering 112(2), 124-129, 2011-08
  • … Vinyl decanoate-modified dextran macromolecules (DexT40-VD) were synthesized in dimethyl sulfoxide at 50℃ using lipase AY from Candida rugosa for catalyzing transesterification between polysaccharide and vinyl fatty esters. …
  • NAID 110008711112

関連リンク

ジメチルスルホキシド (Dimethyl sulfoxide、略称DMSO) は (CH3)2SO の分子式で表 される有機化合物である。純度の高いものは無色無臭だが、長く貯蔵したものは分解物 である硫黄化合物の臭気(磯の香りに似ている)を持つ。非常に吸湿性が高い。 皮膚へ  ...
Structure, classification, information, physical and chemical properties for DMSO, Methyl sulfoxide, Dimethyl sulphoxide, Methylsulfinylmethane, Demasorb, Dimexide, Domoso, Demsodrox, Dromisol.

関連画像

dimethyl sulfoxideDMSO700SQ.jpgDimethyl sulfoxide (DMSO) - microspray - Dimethyl Sulfoxide - 70%dmso dimethyl sulfoxide dimethyl sulfoxide DMSO (Dimethyl sulfoxide) 99.9% - 4 fl. oz


★リンクテーブル★
リンク元胆嚢直接溶解薬」「ジメチルスルホキシド」「DMSO」「dimethylsulfoxide」「dimethyl sulphoxide

胆嚢直接溶解薬」

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  • 利胆薬

胆嚢直接溶解薬


ジメチルスルホキシド」

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dimethyl sulfoxide, DMSO


DMSO」

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dimethyl sulfoxidedimethyl sulphoxidedimethylsulfoxide


dimethylsulfoxide」

  [★]

ジメチルスルホキシド

dimethyl sulfoxidedimethyl sulphoxideDMSO


dimethyl sulphoxide」

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ジメチルスルホキシド

dimethyl sulfoxidedimethylsulfoxideDMSO




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