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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/04 18:32:15」(JST)

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| Name = thyroxine 5'-deiodinase | EC_number = 1.97.1.10 | IUBMB_EC_number = 1/97/1/10 | CAS_number= 70712-46-8 | GO_code = 0004800 | image = | width = | caption = }} Deiodinase (or iodide peroxidase or "Monodeiodinase") is a peroxidase enzyme that is involved in the activation or deactivation of thyroid hormones.

Types

Types of deiodinases include:

family	prosthetic group	genes
Iodothyronine deiodinase	selenium	DIO1, DIO2, DIO3
Iodotyrosine deiodinase	flavin	IYD

In general, T₄ (thyroxine) is converted into T₃ (triiodothyronine) or rT₃ (reverse triiodothyronine) by the iodothyronine deiodinase enzyme in target cells.

Starvation response

In starvation, deiodinase (to be specific, Deiodinase I) is inhibited thus lowering basal metabolic rate. However, in the brain, heart, skeletal muscle and thyroid, this is not so, as these organs must maintain homeostasis (skeletal muscle through shivering can increase temperature). This is achieved by the latter organs expressing deiodinase II rather than Deiodinase I as in most peripheral tissues.^{[citation needed]}

selenium

selenium which is the prosthetic group of iodotyrosine deiodinase ,as selenocysteine, plays a crucial role in determinig the free circulating levels of T_{3. Selenium defeciency can have implications in fall of T_{3 levels.}}

_{External links}

_{Deiodinase at the US National Library of Medicine Medical Subject Headings (MeSH)}

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UpToDate Contents

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1. 甲状腺ホルモンの合成および生理 thyroid hormone synthesis and physiology
2. 甲状腺ホルモンの作用 thyroid hormone action

English Journal

Decreased translation of Dio3 mRNA is associated with drug-induced hepatotoxicity.

Dudek KM, Suter L, Darras VM, Marczylo EL, Gant TW.Source*Systems Toxicology Group, Medical Research Council Toxicology Unit, Hodgkin Building, Lancaster Road, Leicester LE1 9HN, U.K.
The Biochemical journal.Biochem J.2013 Jul 1;453(1):71-82. doi: 10.1042/BJ20130049.
Recent work has demonstrated the importance of post-transcriptional gene regulation in toxic responses. In the present study, we used two rat models to investigate mRNA translation in the liver following xenobiotic-induced toxicity. By combining polysome profiling with genomic methodologies, we were
PMID 23586759

Role of the type 2 iodothyronine deiodinase (D2) in the control of thyroid hormone signaling.

Arrojo E Drigo R, Fonseca TL, Werneck-de-Castro JP, Bianco AC.SourceDivision of Endocrinology, Diabetes and Metabolism, University of Miami, Miller School of Medicine, Miami, FL, USA.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Jul;1830(7):3956-64. doi: 10.1016/j.bbagen.2012.08.019. Epub 2012 Aug 29.
BACKGROUND: Thyroid hormone signaling is critical for development, growth and metabolic control in vertebrates. Although serum concentration of thyroid hormone is remarkable stable, deiodinases modulate thyroid hormone signaling on a time- and cell-specific fashion by controlling the activation and
PMID 22967761

Thyroid hormone's action on progenitor/stem cell biology: New challenge for a classic hormone?

Sirakov M, Skah S, Nadjar J, Plateroti M.SourceInstitut de Biologie et de Médecine Moléculaires, Université Libre de Bruxelles, Belgium.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Jul;1830(7):3917-27. doi: 10.1016/j.bbagen.2012.07.014. Epub 2012 Aug 7.
BACKGROUND: Thyroid hormones are involved in developmental and homeostatic processes in several tissues. Their action results in different outcomes depending on the developmental stage, tissue and/or cellular context. Interestingly, their pleiotropic roles are conserved across vertebrates. It is lar
PMID 22890105

Japanese Journal

Iodotyrosine Deiodinase, a Novel Target of Environmental Halogenated Chemicals for Disruption of the Thyroid Hormone System in Mammals (Recent Advances in the Mechanistic Understanding of Endocrine Disruption by Environmental Chemicals)

Shimizu Ryo
Biological & pharmaceutical bulletin 37(9), 1430-1434, 2014-09
NAID 40020173156

ヒトにおけるSelenoproteinの役割とSelenocysteine insertion sequence-binding protein2(SBP2)異常症の表現型〔簡潔表題 : SBP2異常による甲状腺機能障害(脱ヨード酵素障害)〕 (特集甲状腺ホルモン代謝)

鬼形和道
日本甲状腺学会雑誌 5(1), 32-36, 2014-04
NAID 40020087869

Cytosolic T3-binding protein modulates dynamic alteration of T3-mediated gene expression in cells

, , , , , , , , ,
Endocrine Journal 61(6), 561-570, 2014
… We estimated the constitutive expression of three T3-responsive genes, growth hormone (GH), deiodinase 1 (Dio1), and deiodinase 2 (Dio2), in two cell lines. …
NAID 130004770447

Related Pictures

★リンクテーブル★

リンク元	「脱ヨウ素酵素」「iodide peroxidase」「デヨードナーゼ」

「脱ヨウ素酵素」

　　[★]

英: deiodinase
関: 甲状腺、甲状腺ホルモン

deiodinase	type1(D1)	type2(D2)	type3(D3)
触媒する反応	T₄→T₃→T₂	T₄→T₃	T₃→T₂
触媒する反応	T₄→rT₃→T₂	rT₃→T₂	T₄→rT₃
発現臓器	肝臓、腎臓、甲状腺、下垂体	脳、下垂体、褐色細胞、松果体、心臓、甲状腺、骨格筋、胎盤	脳、皮膚、胎盤
基質親和性	rT3>>T4>T3	T4>rT3	T3>T4
プロピルチオウラシルに対する感受性	＋	－	－