デノボ癌
WordNet
- used to express refusal or denial or disagreement etc or especially to emphasize a negative statement; "no, you are wrong"
- a negative; "his no was loud and clear"
- referring to the degree to which a certain quality is present; "he was no heavier than a child" (同)no more
- not in any degree or manner; not at all; "he is no better today"
- quantifier; used with either mass nouns or plural count nouns for indicating a complete or almost complete lack or zero quantity of; "we have no bananas"; "no eggs left and no money to buy any"; "have you no decency?"; "did it with no help"; "Ill get you there in no time"
- a legal document signed and sealed and delivered to effect a transfer of property and to show the legal right to possess it; "he signed the deed"; "he kept the title to his car in the glove compartment" (同)deed of conveyance, title
- go `ding dong, like a bell (同)dong, dingdong
- a ringing sound
PrepTutorEJDIC
- 《名詞の前に置いて》『一つも』(『一人も,少しも』)・・・『ない』 / 《補語につけて》『決して・・・でない』 / 《省略文で》・・・なし;・・・お断り / 《話》少ししか(あまり)・・・ない / (肯定の問いに対して)『いいえ』;(否定の問いに対して)はい,ええ / 《not, norの前に挿入して》『いや』,否 / 《形容詞の前に置その形容詞を否定して》…どころではない / 《比較級の前に置いて》ちっとも…でない,…と全く同じ / 《… or no の形で》…であってもなくても / 《驚き・困惑・不信などを表して》とんでもない / 《単数形で》『拒否』,「『いいえ』」という返事 / 《複数形で》反対[投]票
- 『行為』,行動 / (正式の)捺印証書,権利書 / …'を'証書を作製して譲渡する
- 〈鐘など〉‘を'ガンガン鳴らす / 〈鐘などが〉ガンガン鳴る / (鐘の)ガンガン鳴る音
- (おもに人称代名詞・固有名詞(人名),thereの後で)had, wouldの短縮形 / (疑問文でwhere,what,whenの後で)didの短縮形;Where'd he go?=Where did he go?
UpToDate Contents
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Japanese Journal
- 平坦・陥凹型早期大腸癌 (特集 大腸癌の組織発生・発育進展を再考する)
- Adenoma-carcinoma sequenceとde novo発癌の病理と臨床 (特集 大腸癌の組織発生・発育進展を再考する)
★リンクテーブル★
[★]
- 英
- de novo cancer
- 同
- de novo癌
[★]
- 英
- cancer
- 関
- 悪性腫瘍
種類
- 癌腫(carcinoma):上皮性
- 肉腫(sarcoma):間葉系
- carcinoma：腺癌(adenocarcinma)、扁平上皮癌(squamous cell carcinoma)、移行上皮癌(transitional cell carcinoma)
- sarcoma：骨肉腫、横紋筋肉腫、平滑筋肉腫、脂肪肉腫、線維肉腫
| Neoplasm
|
Causes
|
Effect
|
| Small cell lung carcinoma
|
ACTH or ACTH-like peptide
|
Cushing’s syndrome
|
| Small cell lung carcinoma and intracranial neoplasms
|
ADH
|
SIADH
|
| Squamous cell lung carcinoma, renal cell carcinoma, breast carcinoma, multiple myeloma, and bone metastasis (lysed bone)
|
PTH-related peptide, TGF-β, TNF-α, IL-1
|
Hypercalcemia
|
| Renal cell carcinoma, hemangioblastoma
|
Erythropoietin
|
Polycythemia
|
| Thymoma, small cell lung carcinoma
|
Antibodies against presynaptic Ca2+ channels at neuromuscular junction
|
Lambert-Eaton syndrome (muscle weakness)
|
| Leukemias and lymphomas
|
Hyperuricemia due to excess nucleic acid turnover (i.e., cytotoxic therapy)
|
Gout, urate nephropathy
|
- http://ganjoho.ncc.go.jp/public/statistics/pub/statistics01.html
| ●2005年の死亡数が多い部位は順に
|
|
|
1位
|
2位
|
3位
|
4位
|
5位
|
|
| 男性
|
肺
|
胃
|
肝臓
|
結腸
|
膵臓
|
結腸と直腸を合わせた大腸は4位
|
| 女性
|
胃
|
肺
|
結腸
|
肝臓
|
乳房
|
結腸と直腸を合わせた大腸は1位
|
| 男女計
|
肺
|
胃
|
肝臓
|
結腸
|
膵臓
|
結腸と直腸を合わせた大腸は3位
|
|
|
| ●2001年の罹患数が多い部位は順に
|
|
|
1位
|
2位
|
3位
|
4位
|
5位
|
|
| 男性
|
胃
|
肺
|
結腸
|
肝臓
|
前立腺
|
結腸と直腸を合わせた大腸は2位
|
| 女性
|
乳房*1
|
胃
|
結腸
|
子宮*1
|
肺
|
結腸と直腸を合わせた大腸は1位
|
| 男女計
|
胃
|
肺
|
結腸
|
乳房*1
|
肝臓
|
結腸と直腸を合わせた大腸は2位
|
| *1上皮内がんを含む。
|
癌の素因となる遺伝子
- HIM.494
| Table 79-1 Cancer Predisposition Syndromes and Associated Genes
|
| Syndrome
|
Gene
|
Chromosome
|
Inheritance
|
Tumors
|
| ataxia telangiectasia
|
ATM
|
11q22-q23
|
AR
|
breast cancer
|
| autoimmune lymphoproliferative syndrome
|
FAS
|
10q24
|
AD
|
lymphomas
|
| FASL
|
1q23
|
|
| Bloom syndrome
|
BLM
|
15q26.1
|
AR
|
cancer of all types
|
| Cowden syndrome
|
PTEN
|
10q23
|
AD
|
breast, thyroid
|
| familial adenomatous polyposis
|
APC
|
5q21
|
AD
|
intestinal adenoma, colorectal cancer
|
| familial melanoma
|
p16INK4
|
9p21
|
AD
|
melanoma, pancreatic cancer
|
| familial Wilms tumor
|
WT1
|
11p13
|
AD
|
pediatric kidney cancer
|
| hereditary breast/ovarian cancer
|
BRCA1
|
17q21
|
AD
|
breast, ovarian, colon, prostate
|
| BRCA2
|
13q12.3
|
|
| hereditary diffuse gastric cancer
|
CDH1
|
16q22
|
AD
|
stomach cancers
|
| hereditary multiple exostoses
|
EXT1
|
8q24
|
AD
|
exostoses, chondrosarcoma
|
| EXT2
|
11p11-12
|
|
| hereditary prostate cancer
|
HPC1
|
1q24-25
|
AD
|
prostate carcinoma
|
| hereditary retinoblastoma
|
RB1
|
13q14.2
|
AD
|
retinoblastoma, osteosarcoma
|
| hereditary nonpolyposis colon cancer (HNPCC)
|
MSH2
|
2p16
|
AD
|
colon, endometrial, ovarian, stomach, small bowel, ureter carcinoma
|
| MLH1
|
3p21.3
|
|
| MSH6
|
2p16
|
|
| PMS2
|
7p22
|
|
| hereditary papillary renal carcinoma
|
MET
|
7q31
|
AD
|
papillary renal tumor
|
| juvenile polyposis
|
SMAD4
|
18q21
|
AD
|
gastrointestinal, pancreatic cancers
|
| Li-Fraumeni
|
TP53
|
17p13.1
|
AD
|
sarcoma, breast cancer
|
| multiple endocrine neoplasia type 1
|
MEN1
|
11q13
|
AD
|
parathyroid, endocrine, pancreas, and pituitary
|
| multiple endocrine neoplasia type 2a
|
RET
|
10q11.2
|
AD
|
medullary thyroid carcinoma, pheochromocytoma
|
| neurofibromatosis type 1
|
NF1
|
17q11.2
|
AD
|
neurofibroma, neurofibrosarcoma, brain tumor
|
| neurofibromatosis type 2
|
NF2
|
22q12.2
|
AD
|
vestibular schwannoma, meningioma, spine
|
| nevoid basal cell carcinoma syndrome (Gorlin's syndrome)
|
PTCH
|
9q22.3
|
AD
|
basal cell carcinoma, medulloblastoma, jaw cysts
|
| tuberous sclerosis
|
TSC1
|
9q34
|
AD
|
angiofibroma, renal angiomyolipoma
|
| TSC2
|
16p13.3
|
|
| von Hippel–Lindau
|
VHL
|
3p25-26
|
AD
|
kidney, cerebellum, pheochromocytoma
|
- 癌遺伝子、癌抑制遺伝子
癌の危険因子
- 生活習慣病#生活習慣病などのリスクファクターを改変
[★]
- 関
- anew、newly、novel
[★]
線量当量 dose equivalent