出典: meddic


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「an amino acid containing sulfur that is found in most proteins; oxidizes on exposure to air to form cystine」

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/10/04 19:45:38」(JST)

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  • Novel conductometric biosensor based on three-enzyme system for selective determination of heavy metal ions.
  • Soldatkin OO, Kucherenko IS, Pyeshkova VM, Kukla AL, Jaffrezic-Renault N, El'skaya AV, Dzyadevych SV, Soldatkin AP.SourceInstitute of Molecular Biology and Genetics of National Academy of Sciences of Ukraine, Zabolotnogo Street 150, 03143 Kyiv, Ukraine.
  • Bioelectrochemistry (Amsterdam, Netherlands).Bioelectrochemistry.2012 Feb;83:25-30. Epub 2011 Aug 18.
  • A differential pair of planar thin-film interdigitated electrodes, deposited on a ceramic pad, was used as a conductometric transducer. The three-enzyme system (invertase, mutarotase, glucose oxidase), immobilized on the transducer surface, was used as a bioselective element. The ratio between enzym
  • PMID 21903487
  • STM and cyclic voltammetric investigation of recombinant azurin-gold nanoparticle hybrids.
  • Yagati AK, Lee T, Min J, Choi JW.SourceInterdisciplinary Program of Integrated Biotechnology, Sogang University, #1 Shinsu-dong, Mapo-gu, Seoul, 121-742, Republic of Korea.
  • Bioelectrochemistry (Amsterdam, Netherlands).Bioelectrochemistry.2012 Feb;83:8-14. Epub 2011 Jul 27.
  • Here, we developed a method for the formation of redox metalloprotein azurin (Az) and gold nanoparticle (Au-NP) hybrid and evaluated its electrical and electrochemical properties using a combination of scanning tunneling microscopy (STM)/scanning tunneling spectroscopy (STS). A cysteine residue was
  • PMID 21840267


  • Enzymatic synthesis of chiral amino acid sulfoxides by Fe(II)/α-ketoglutarate-dependent dioxygenase
  • Hibi Makoto,Kawashima Takashi,Yajima Hiroko,Smirnov Sergey V.,Kodera Tomohiro,Sugiyama Masakazu,Shimizu Sakayu,Yokozeki Kenzo,Ogawa Jun
  • Tetrahedron: Asymmetry 24(17), 990-994, 2013-09-00
  • … The IDO catalyzed sulfoxidation of l-methionine, l-ethionine, S-methyl-l-cysteine, S-ethyl-l-cysteine, and S-allyl-l-cysteine into the corresponding (S)-configured sulfoxides such as (+)-methiin and (+)-alliin, which are responsible for valuable physiological activities in mammals, and have high stereoselectivity. …
  • NAID 120005323888
  • Identification of the recognition sequence and target proteins for DJ-1 protease
  • Mitsugi Hitomi,Niki Takeshi,Takahashi-Niki Kazuko,Tanimura Kyoko,Yoshizawa-Kumagaye Kumiko,Tsunemi Masahiko,Iguchi-Ariga Sanae M. M.,Ariga Hiroyoshi
  • Febs letters 587(16), 2493-2499, 2013-08-19
  • … DJ-1, the product of familial Parkinson's disease gene and an oncogene, is a cysteine protease which plays a role in anti-oxidative stress reaction. …
  • NAID 120005326755
  • Five amino acid residues in cysteine-rich domain of human T1R3 were involved in the response for sweet-tasting protein, thaumatin.
  • Masuda Tetsuya,Taguchi Wakana,Sano Ayane,Ohta Keisuke,Kitabatake Naofumi,Tani Fumito
  • Biochimie 95(7), 1502-1505, 2013-07-00
  • … Although it was shown that the cysteine-rich domain (CRD) of human T1R3 (hT1R3) is important for the response to thaumatin, the amino acid residues within CRD critical for response are still unknown. …
  • NAID 120005293582


Cysteine (abbreviated as Cys or C) is an α-amino acid with the chemical formula HO2CCH(NH2)CH2SH. It is a semi-essential amino acid, which means that it can be biosynthesized in humans. The thiol side chain in cysteine often participates ...






3,3'-ジチオビス(2-アミノプロピオン酸) 3,3'-dithiobis(2-aminopropionic acid)
システイン cysteine

  • システインが酸化されて2分子結合したもの。
  • 溶解度は低い。
  • システインのpK1=1.92, pK=10.7がそのまま適応できるとすれば、等電点であるpI=6.31に向かって溶解度が低下する。このため、酸性条件でシスチン結石が形成されやすいと考えられる。
  • pKCOOH<1 pKCOOH=2.1 pKNH3+=8.02 pKNH3+=8.71 pI=5.03 (参考文献(1)より)



  • 1. 物性



cysteine, Cys, C
チオセリン thioserine2-アミノ-3-メルカプトプロピオン酸 2-amino-3-mercaptopropionic acid