関: corneal angiogenesis、corneal neovascularization

WordNet

the transparent dome-shaped anterior portion of the outer covering of the eye; it covers the iris and pupil and is continuous with the sclera
of or related to the cornea

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(眼球の)角膜
角膜の

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/29 17:05:23」(JST)

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Corneal neovascularization is the excessive ingrowth of blood vessels from the limbal vascular plexus into the cornea, caused by deprivation of oxygen from the air. One of the most common causes is contact lens wear and, in particular, the use of older hydrogel contact lens materials such as HEMA ((2-hydroxy-ethyl methacrylate) for both daily and extended wear. Such older hydrogel materials have a relatively low oxygen transmissibility so the cornea ends up being starved of oxygen hence the response of the ingress of blood capillaries into the clear cornea to satisfy that oxygen demand.

More modern rigid gas permeable and silicon hydrogel contact lenses have a much higher level of oxygen transmissibility so this problem tends not to occur with these types of lenses even with the use of silicon hydrogel lenses for extended wear. The condition could threaten one's eyesight in the advanced stages, which is one of the primary reasons eye care physicians strongly recommend routine (annual) exams for contact lens patients. Patients suffering from this problem can be fitted with lenses made of the modern silicon hydrogel and that tends to solve the problem.

Reduction of neovascularization has been achieved in rats by the topical instillation of commercially available triamcinolone and doxycycline.^[1]

References

^ PMID 17068457

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External links

Corneal Neovascularization
Oxygen Transmissibility

UpToDate Contents

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English Journal

Treatment with mPEG-SPA improves the survival of corneal grafts in rats by immune camouflage.

Wang S1, Li L2, Liu Y3, Li C4, Zhang M5, Wang B6, Huang Z7, Gao X8, Wang Z9.
Biomaterials.Biomaterials.2015 Mar;43:13-22. doi: 10.1016/j.biomaterials.2014.12.001. Epub 2014 Dec 20.
We investigated the immune camouflage effects of methoxy polyethylene glycol succinimidyl propionate (mPEG-SPA) on corneal antigens and explored a novel approach for reducing corneal antigenicity, thereby decreasing corneal graft rejection. Importantly, this approach did not alter normal local immun
PMID 25591957

Heterochromatin protein 1 alpha (HP1α: CBX5) is a key regulator in differentiation of endothelial progenitor cells to endothelial cells.

Maeng YS1, Kwon JY, Kim EK, Kwon YG.
Stem cells (Dayton, Ohio).Stem Cells.2015 Jan 14. doi: 10.1002/stem.1954. [Epub ahead of print]
As the ability to control the differentiation of endothelial stem/progenitor cells (EPCs) into vascular endothelial cell lineages could be useful for promoting neovascularization, it is important to obtain a deeper understanding of the epigenetic mechanisms that regulate EPC differentiation and neov
PMID 25588582

Ocular Drug Delivery Nanowafer with Enhanced Therapeutic Efficacy.

Yuan X, Marcano DC, Shin CS, Hua X, Isenhart LC, Pflugfelder SC, Acharya G.
ACS nano.ACS Nano.2015 Jan 13. [Epub ahead of print]
Presently, eye injuries are treated by topical eye drop therapy. Because of the ocular surface barriers, topical eye drops must be applied several times in a day, causing side effects such as glaucoma, cataract, and poor patient compliance. This article presents the development of a nanowafer drug d
PMID 25585134