角膜血管新生
- 関
- corneal angiogenesis、corneal neovascularisation
WordNet
- the transparent dome-shaped anterior portion of the outer covering of the eye; it covers the iris and pupil and is continuous with the sclera
- of or related to the cornea
PrepTutorEJDIC
- (眼球の)角膜
- 角膜の
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/11/15 16:58:17」(JST)
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Corneal neovascularization |
Classification and external resources |
Specialty |
ophthalmology |
ICD-10 |
H16.4 |
[edit on Wikidata]
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Corneal neovascularization is the excessive ingrowth of blood vessels from the limbal vascular plexus into the cornea, caused by deprivation of oxygen from the air.
Contents
- 1 Cause
- 2 Pathogenesis
- 2.1 Chemical theory
- 2.2 Mechanical theory
- 2.3 Combined theory
- 3 Treatment
- 4 Complications
- 5 Research
- 6 References
- 7 External links
Cause
One of the most common cause of corneal neovascularization is contact lens wear, especially those made with older hydrogel contact lens materials such as HEMA (2-hydroxyethyl methacrylate) for both daily and extended wear. Such older hydrogel materials have a relatively low oxygen transmissibility so the cornea ends up being starved of oxygen hence the response of the ingress of blood capillaries into the clear cornea to satisfy that oxygen demand. Also, there has been multiple causes proved to be involved with corneal neovascularization, including herpes simplex and corneal ulcers.[1]
Pathogenesis
Chemical theory
There may be presence of vasostimulatory factor (VSF) or the breakdown (destruction) of previously existing vasoinhibitory factor (VIF).[2]
Mechanical theory
Blood vessels cannot invade normal cornea because of its compactness and loosening of the compactness of corneal tissue due to oedema was mandatory for neovascularization.
Combined theory
Both release of some vasostimulatory factor (VSF) and structural loosening of compact corneal stroma by oedema are necessary for the neovascularization to occur.[3]
Treatment
Modern rigid gas permeable and silicon hydrogel contact lenses have a much higher level of oxygen transmissibility, making them effective alternatives to help prevent corneal neovascularization.
Complications
In advanced stages, corneal neovascularization can threaten eyesight, which is why eye routine (annual) exams are recommended for contact lens patients.
Research
Reduction of neovascularization has been achieved in rats by the topical instillation of commercially available triamcinolone and doxycycline.[4]
Some evidence exists to suggest that the Angiotensin II receptor blocker drug telmisartan will prevent corneal neovascularization.[5]
Recent treatment developments include, topical application of bevacizumab, an anti-VEGF.[6]
References
- ^ Abdelfattah, NS; Amgad, M; Zayed, AA; Salem, H; Elkhanany, AE; Hussein, H; Abd El-Baky, N (2015). "Clinical correlates of common corneal neovascular diseases: a literature review.". International journal of ophthalmology. 8 (1): 182–93. doi:10.3980/j.issn.2222-3959.2015.01.32. PMID 25709930.
- ^ Abdelfattah NS, Amgad M, Zayed AA, Hussein H, Abd El-Baky N. Molecular underpinnings of corneal angiogenesis: advances over the past decade. Int J Ophthalmol. 2016 May 18;9(5):768-79
- ^ Abdelfattah NS, Amgad M, Zayed AA. Host immune cellular reactions in corneal neovascularization. Int J Ophthalmol. 2016 Apr 18;9(4):625-33.
- ^ Riazi-Esfahani, M; Peyman, GA; Aydin, E; Kazi, AA; Kivilcim, M; Sanders, DR (August 2006). "Prevention of corneal neovascularization: evaluation of various commercially available compounds in an experimental rat model.". Cornea. 25 (7): 801–5. doi:10.1097/01.ico.0000220768.11778.60. PMID 17068457.
- ^ Usui, T.; Sugisaki, K.; Iriyama, A.; Yokoo, S.; Yamagami, S.; Nagai, N.; Ishida, S.; Amano, S. (2008). "Inhibition of Corneal Neovascularization by Blocking the Angiotensin II Type 1 Receptor". Investigative Ophthalmology & Visual Science. 49 (10): 4370–4376. doi:10.1167/iovs.07-0964. PMID 18829859.
- ^ Cheng, Sheng-Fu; Dastjerdi, Mohammad H.; Ferrari, Giulio; Okanobo, Andre; Bower, Kraig S.; Ryan, Denise S.; Amparo, Francisco; Stevenson, William; Hamrah, Pedram; Nallasamy, Nambi; Dana, Reza (December 2012). "Short-Term Topical Bevacizumab in the Treatment of Stable Corneal Neovascularization". American Journal of Ophthalmology. 154 (6): 940–948.e1. doi:10.1016/j.ajo.2012.06.007.
External links
UpToDate Contents
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English Journal
- Anti-angiogenic effect of a humanized antibody blocking the Wnt/β-catenin signaling pathway.
- Qiu F1, Shin Y2, Chen D3, Cheng R4, Chen Q5, Zhou K6, Larrick JW7, Mendelson AR7, Ma JX8.
- Microvascular research.Microvasc Res.2018 Sep;119:29-37. doi: 10.1016/j.mvr.2018.03.011. Epub 2018 Apr 7.
- PMID 29630973
- Xanthatin inhibits corneal neovascularization by inhibiting the VEGFR2‑mediated STAT3/PI3K/Akt signaling pathway.
- Shen M1, Zhou XZ2, Ye L3, Yuan Q3, Shi C4, Zhu PW3, Jiang N3, Ma MY3, Yang QC5, Shao Y3.
- International journal of molecular medicine.Int J Mol Med.2018 Aug;42(2):769-778. doi: 10.3892/ijmm.2018.3646. Epub 2018 Apr 30.
- PMID 29717775
- Herpetic eye disease study: lessons learned.
- Kalezic T1, Mazen M2, Kuklinski E2, Asbell P2.
- Current opinion in ophthalmology.Curr Opin Ophthalmol.2018 Jul;29(4):340-346. doi: 10.1097/ICU.0000000000000482.
- PMID 29846207
Japanese Journal
- Deterioration of Glaucoma After Carotid Endarterectomy:—Case Report—
- KATSUTA Toshiro,FUJIMOTO Akiko,OBA Kumiyo
- Neurologia medico-chirurgica 53(6), 418-421, 2013
- … Right intraocular pressure was markedly increased, and corneal edema and increased iris neovascularization were also recognized. … Ocular ischemia causes not only neovascularization of the iris, which leads to insufficient resorption of the aqueous humor, but also insufficient production of the aqueous humor. …
- NAID 130003364259
- 眼科医にもわかる 生理活性物質と眼疾患の基本(30)臨床編 各種眼疾患と生理活性物質とのかかわり 角膜血管新生
- 臨床報告 角膜新生血管に対しベバシズマブ点眼が有効であった1例
Related Links
- I. Introduction The cornea is normally an avascular, transparent connective tissue that serves as a mechanical barrier and the anterior refractive surface of the eye. It is supplied by the ciliary arteries, branches of the ophthalmic artery ...
- Pathologic ingrowth of vessels from the limbal vascular plexus into the cornea. Clinical features: Symptoms: may be asymptomatic or mild to severe decrease of vision. Signs: Fine, superficial ...
★リンクテーブル★
[★]
- 英
- corneal neovascularization、((英))corneal neovascularisation、corneal angiogenesis
[★]
角膜血管新生
- 関
- corneal neovascularisation、corneal neovascularization
[★]
角膜血管新生
- 関
- corneal angiogenesis、corneal neovascularization
[★]
- 関
- cornea