WordNet

the transparent dome-shaped anterior portion of the outer covering of the eye; it covers the iris and pupil and is continuous with the sclera
of or related to the cornea
the formation of new blood vessels

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In situ covalently cross-linked PEG hydrogel for ocular drug delivery applications.

Yu J1, Xu X1, Yao F2, Luo Z2, Jin L1, Xie B1, Shi S1, Ma H1, Li X3, Chen H1.
International journal of pharmaceutics.Int J Pharm.2014 Aug 15;470(1-2):151-7. doi: 10.1016/j.ijpharm.2014.04.053. Epub 2014 Apr 23.
Avastin(®) has been clinically proved to be effective in the treatment of intraocular neovascularization diseases. However, the short half-life of Avastin(®) need frequent administration to maintain its therapeutic efficiency. In this paper, we attempted to develop an in situ PEG hydrogels with gr
PMID 24768405

Inhibition of blood vessel formation by a chondrocyte-derived extracellular matrix.

Choi BH1, Choi KH2, Lee HS3, Song BR2, Park SR4, Yang JW5, Min BH6.
Biomaterials.Biomaterials.2014 Jul;35(22):5711-20. doi: 10.1016/j.biomaterials.2014.03.083. Epub 2014 Apr 22.
In this study, the chondrocyte-derived extracellular matrix (CECM) was evaluated for its activity to inhibit vessel invasion in vitro and in vivo. Human umbilical vein endothelial cells (HUVECs) and rabbit chondrocytes were plated on a bio-membrane made of CECM or human amniotic membrane (HAM). Th
PMID 24768193

Early effects of dexamethasone and anti-VEGF therapy in an inflammatory corneal neovascularization model.

Mirabelli P1, Peebo BB2, Xeroudaki M1, Koulikovska M1, Lagali N1.
Experimental eye research.Exp Eye Res.2014 Jun 13. pii: S0014-4835(14)00167-5. doi: 10.1016/j.exer.2014.06.006. [Epub ahead of print]
Inflammatory angiogenesis is the pathogenic mechanism of various sight-threatening eye diseases, among them corneal neovascularization. Current treatment options include steroids which have undesirable side effects, or anti-VEGF which has only limited efficacy. In an inflammatory environment, howeve
PMID 24933712

曽根曜子,越智榮子,松山晃子,普久原聡子,合田光寛,髙取真吾,川博已
薬学雑誌 132(2), 157-160, 2012
… Angiogenesis, or new blood vessel formation, is critical for the growth and spread of tumors. … Therefore, the aim of this study is to investigate effect of NGF on distribution of perivascular nerves and neovessel form in tumor tissues, which were generated by mouse corneal micropocket method. … A gel, which contained DU145 prostate carcinoma cells, was implanted into the mouse corneal. …
NAID 130001872001

Wound Healing Fibroblasts Modulate Corneal Angiogenic Privilege : Interplay of Basic Fibroblast Growth Factor and Matrix Metalloproteinases in Corneal Angiogenesis