WordNet

make complete or perfect; supply what is wanting or form the complement to; "I need some pepper to complement the sweet touch in the soup"
a complete number or quantity; "a full complement"
one of a series of enzymes in the blood serum that are part of the immune response
something added to complete or embellish or make perfect; "a fine wine is a perfect complement to the dinner"; "wild rice was served as an accompaniment to the main dish" (同)accompaniment
number needed to make up a whole force; "a full complement of workers" (同)full complement
a word or phrase used to complete a grammatical construction
either of two parts that mutually complete each other
an artifact that is one of the individual parts of which a composite entity is made up; especially a part that can be separated from or attached to a system; "spare components for cars"; "a component or constituent element of a system" (同)constituent, element
an abstract part of something; "jealousy was a component of his character"; "two constituents of a musical composition are melody and harmony"; "the grammatical elements of a sentence"; "a key factor in her success"; "humor: an effective ingredient of a s (同)constituent, element, factor, ingredient

PrepTutorEJDIC

(あるものを完全にするため)(…を)補う物(事)《+『of』+『名』》 / 補語(文法で文の成分の一つ) / (必要な)全数,全量;(船の)定員 / …を補足する,補う
構成している,成分の / 構成要素,成分

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/03/21 07:08:40」(JST)

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Complement component 5 is a protein that in humans is encoded by the C5 gene.^[5]

Complement component 5 is involved in the complement system. It is cleaved into C5a and C5b:

C5a plays an important role in chemotaxis.^[6]
C5b forms the first part of the complement membrane attack complex.

Deficiency is thought to cause Leiner's disease.

Function

Complement component 5 is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is composed of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a C5-convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components.^[5]

Clinical significance

Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.^[5]

Therapeutic applications

The drug eculizumab (trade name Soliris) prevents cleavage of C5 into C5a and C5b.^[7]

Complement system pathway

Membrane attack complex. Some labels are in Polish.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106804 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026874 - Ensembl, May 2017
^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ ^a ^b ^c "Entrez Gene: complement component 5".
^ Immunology at MCG 1/phagocyt
^ Dubois E, Cohen A (2009). "Eculizumab". Br J Clin Pharmacol. 68 (3): 318–319. doi:10.1111/j.1365-2125.2009.03491.x. PMC 2766470 . PMID 19740388.

External links

Complement 5 at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. 補体系の概要および臨床的評価 overview and clinical assessment of the complement system
2. 補体系の遺伝性疾患 inherited disorders of the complement system
3. 補体経路 complement pathways
4. 感染症を繰り返す小児に対するアプローチ approach to the child with recurrent infections
5. 補体系の後天性欠損 acquired deficiencies of the complement system

English Journal

Anti-complementary activity of two homogeneous polysaccharides from Eclipta prostrata.

Wang H1, Li N1, Zhu C1, Shi S1, Jin H2, Wang S3.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2017 Nov 18;493(2):887-893. doi: 10.1016/j.bbrc.2017.09.126. Epub 2017 Sep 23.
PMID 28951216

The role of complement in the acute phase response after burns.

Korkmaz HI1, Krijnen PAJ2, Ulrich MMW3, de Jong E4, van Zuijlen PPM5, Niessen HWM6.
Burns : journal of the International Society for Burn Injuries.Burns.2017 Nov;43(7):1390-1399. doi: 10.1016/j.burns.2017.03.007. Epub 2017 Apr 12.
PMID 28410933

Magnetic bead based assays for complement component C5.

DiScipio RG1, Schraufstatter IU2.
Journal of immunological methods.J Immunol Methods.2017 Nov;450:50-57. doi: 10.1016/j.jim.2017.07.010. Epub 2017 Jul 27.
PMID 28757372

Japanese Journal

A simple PCR-based method for the rapid genotyping of inherited fifth complement component (C5)-deficient mice

WANG Qingkai,WANG Na,ZHANG Xin [他]
Experimental animals 64(3), 261-268, 2015-07
NAID 40020532451

A simple PCR-based method for the rapid genotyping of inherited fifth complement component (C5)-deficient mice

WANG Qingkai,WANG Na,ZHANG Xin,HU Weiguo
Experimental Animals 64(3), 261-268, 2015
… The fifth component of complement (C5) is considered to be the center of complement activation and function. … Using ARMS-PCR method, we generated C5-deficient mice in the C57BL/6 background over 9 backcrossed generations and further verified the phenotype using complement-mediated hemolytic assays. …
NAID 130005091026

生分解性ポリエステル多孔質膜に支持された培養細胞シート

民部裕洋,田中孝明
膜 40(3), 124-129, 2015
… Established osteoblast–like (Saos–2) cells grew on a flexible microporous membrane of PCL and hydroxyapatite, the latter of which is a major mineral component of bone and used in bone defect treatment, although the cells grew in a single layer. … The biodegradable microporous sheets including those described in the review will complement the existing cultured cell sheet technology. …
NAID 130005075555

「C5」

C5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1CFA, 1KJS, 1XWE, 3CU7, 3HQA, 3HQB, 3KLS, 3KM9, 3PRX, 3PVM, 4A5W, 4E0S, 4P39, 4UU9, 5I5K, 5HCE, 5HCC, 5HCD
Identifiers
Aliases	C5, C5D, C5a, C5b, CPAMD4, ECLZB, complement component 5, complement C5
External IDs	OMIM: 120900 MGI: 96031 HomoloGene: 20412 GeneCards: C5
Gene location (Human)
Chr.	Chromosome 9 (human)
End	121,050,276 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	35,061,438 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• chemokine activity; • protein binding; • endopeptidase inhibitor activity; • receptor binding;
Cellular component	• extracellular region; • extracellular exosome; • membrane attack complex; • extracellular space;
Biological process	• G-protein coupled receptor signaling pathway; • cytolysis; • complement activation, alternative pathway; • immune system process; • positive regulation of chemokine secretion; • complement activation; • response to stress; • in utero embryonic development; • positive regulation of angiogenesis; • chemotaxis; • cell surface receptor signaling pathway; • activation of MAPK activity; • complement activation, classical pathway; • positive regulation of vascular endothelial growth factor production; • inflammatory response; • regulation of complement activation; • negative regulation of macrophage chemotaxis; • negative regulation of endopeptidase activity; • innate immune response; • cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
	727
	15139
	ENSG00000106804
	ENSMUSG00000026874
	P01031
	P06684
	NM_001735; NM_001317163; NM_001317164
	NM_010406
	NP_001304092; NP_001304093; NP_001726
	NP_034536
	Wikidata
View/Edit Human	View/Edit Mouse