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English Journal

Differential Effects of Atorvastatin and Pitavastatin on Inflammation, Insulin Resistance, and the Carotid Intima-Media Thickness in Patients with Dyslipidemia.

Nakagomi A1, Shibui T, Kohashi K, Kosugi M, Kusama Y, Atarashi H, Shimizu W.
Journal of atherosclerosis and thrombosis.J Atheroscler Thromb.2015 Jun 17. [Epub ahead of print]
AIMS: 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have multiple pleiotropic effects, such as anti-inflammatory and vascular endothelium protection, that are independent of their low-density-lipoprotein (LDL) cholesterol lowering effects. However, whether different statins ex
PMID 26084792

Briguglio I1, Piras S1, Corona P1, Gavini E1, Nieddu M1, Boatto G1, Carta A2.
European journal of medicinal chemistry.Eur J Med Chem.2015 Jun 5;97:612-648. doi: 10.1016/j.ejmech.2014.09.089. Epub 2014 Sep 30.
Discovered in late 1960, azoles are heterocyclic compounds class which constitute the largest group of available antifungal drugs. Particularly, the imidazole ring is the chemical component that confers activity to azoles. Triazoles are obtained by a slight modification of this ring and similar or
PMID 25293580

Coenzyme Q10 remarkably improves the bio-energetic function of rat liver mitochondria treated with statins.

Mohammadi-Bardbori A1, Najibi A2, Amirzadegan N2, Gharibi R2, Dashti A2, Omidi M2, Saeedi A2, Ghafarian-Bahreman A2, Niknahad H3.
European journal of pharmacology.Eur J Pharmacol.2015 May 22;762:270-274. doi: 10.1016/j.ejphar.2015.05.041. [Epub ahead of print]
CoQ10 shares a biosynthetic pathway with cholesterol therefore it can be a potential target of the widely available lipid-lowering agents such as statins. Statins are the most widely prescribed cholesterol-lowering drugs with the ability to inhibit HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) red
PMID 26007644

Standard-Dose Statin Therapy Provides Incremental Clinical Benefits in Normocholesterolemic Diabetic Patients

KOJIMA Sunao,SAKAMOTO Tomohiro,OGAWA Hisao,KITAGAWA Akira,MATSUI Kunihiko,SHIMOMURA Hideki,KIMURA Kazuo,OGATA Yasuhiro,SAKAINO Naritsugu,the Multicenter Study for Aggressive Lipid-lowering Strategy by HMG-CoA Reductase Inhibitors MUSASHI investigators
Circulation journal : official journal of the Japanese Circulation Society 74(4), 779-785, 2010-03-25
… A total number of 1,016 CHD patients (301 patients with type 2 diabetes mellitus [DM] and 715 non-DM patients) with serum total cholesterol levels of 180-240 mg/dl were randomly divided into non-statin and statin treatments. … Serum low-density lipoprotein (LDL)-cholesterol levels were equally decreased after statin treatment in the 2 groups. … Conclusions: Standard-dose statin therapy provides incremental clinical benefits in DM patients with normal cholesterol levels compared with non-DM patients. …
NAID 10026472717

Hypolipidemic Effects of Sophora flavescens and Its Constituents in Poloxamer 407-Induced Hyperlipidemic and Cholesterol-Fed Rats(Pharmacognosy)

KIM Hyun Young,JEONG Da Mi,JUNG Hee Jin,JUNG Yu Jung,YOKOZAWA Takako,CHOI Jae Sue
Biological & pharmaceutical bulletin 31(1), 73-78, 2008-01-01
… In this study, we investigated the hypolipidemic effects of Sophora flavescens in poloxamer 407-induced hyperlipidemic and cholesterol-fed rats. … Serum lipid levels such as total cholesterol (TC), triglycerides (TG), and low-density lipoprotein-cholesterol (LDL-C) were markedly elevated in the poloxamer 407-induced hyperlipidemic control rats, while lipid levels were significantly decreased in the rats administered the MeOH extract or 4 fractions of S. …
NAID 110006569977