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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/24 11:26:11」(JST)
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A centrocyte generally refers to a B cell with a cleaved nucleus,[1] as may appear in e.g. follicular lymphoma.[2]
During B cell development, centrocytes are formed following the cessation of centroblast proliferation. Centrocytes test their newly mutated anti-binding sites (CDR loops) by re-expressing antigen on their surface.
Centrocyte can also refer to a cell with a protoplasm that contains single and double granules of varying size stainable with hematoxylin, as seen in lesions of lichen planus,[1] or a nondividing, activated B cell that expresses membrane immunoglobulin.[1]
References
- ^ a b c [1] Stedman's Medical Dictionary. 2006
- ^ Table 12-8 in: Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. Robbins Basic Pathology. Philadelphia: Saunders. ISBN 1-4160-2973-7. 8th edition.
UpToDate Contents
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English Journal
- Colonic mucosa-associated lymphoid tissue lymphoma.
- Akasaka R, Chiba T, Dutta AK, Toya Y, Mizutani T, Shozushima T, Abe K, Kamei M, Kasugai S, Shibata S, Abiko Y, Yokoyama N, Oana S, Hirota S, Endo M, Uesugi N, Sugai T, Suzuki K.SourceDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical University, Morioka, Japan.
- Case reports in gastroenterology.Case Rep Gastroenterol.2012 May;6(2):569-75. Epub 2012 Aug 29.
- Colonic mucosa-associated lymphoid tissue (MALT) lymphomas are rare and a definitive treatment has not been established. Solitary or multiple, elevated or polypoid lesions are the usual appearances of MALT lymphoma in the colon and sometimes the surface may reveal abnormal vascularity. In this paper
- PMID 23012617
- [Clinicopathologic features of primary thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue type].
- Sun L, Shi HY, Wei LX.SourceDepartment of Pathology, General Hospital of People's Liberation Army, Beijing 100853, China.
- Zhonghua bing li xue za zhi Chinese journal of pathology.Zhonghua Bing Li Xue Za Zhi.2012 Apr;41(4):234-8.
- OBJECTIVE: To study the clinicopathologic features of primary thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT).METHODS: The clinical and pathologic findings were evaluated in 3 cases of biopsy confirmed thymic MALT lymphoma. The clincopathologic features, t
- PMID 22800518
Japanese Journal
- CD5-Negative Mantle Cell Lymphoma Resembling Extranodal Marginal Zone Lymphoma of <BR>Mucosa-Associated Lymphoid Tissue : A Case Report
- Hashimoto Yoshinori,Omura Hiromi,Tanaka Takayuki,Hino Norihiko,Nakamoto Shu
- Journal of Clinical and Experimental Hematopathology 52(3), 185-191, 2012
- … Colonoscopy revealed the appearance of multiple lymphomatous polyposis and biopsy specimens showed monotonous proliferation of centrocyte-like cells (CD79a<SUP>+</SUP>, CD20<SUP>+</SUP>, CD3<SUP>-</SUP>, CD5<SUP>-</SUP>, CD10<SUP>-</SUP>, and cyclin D1<SUP>+</SUP>), which were consistent with mantle cell lymphoma (MCL) except for CD5. …
- NAID 130003322357
- 胚中心B細胞の分化と濾胞樹状細胞 (特集 B細胞の機能発現とその制御)
- 悪性リンパ腫びまん性大細胞型Bリンパ腫(Diffuse large B-cell lymphoma)の発生母地と亜分類に関する検討
- 吾妻 美子,宮元 祥平
- 高知学園短期大学紀要 41, 37-45, 2011-03-10
- … GCB typeの腫瘍細胞は、くびれのあるクロマチンの豊富な核を有し、細胞質の乏しいcentroblasticないしはcentrocyte様細胞であった。 …
- NAID 110009487528
Related Links
- 暗調域 dark zone:被膜から遠い:B細胞が増殖(SIGなし):中心芽細胞 centroblast · 基底側明調域 basal light zone:SIGを発現したB細胞:中心細胞 centrocyte:さらに 濾胞樹状細胞より抗原提示を受けて抗体産生するようになる; 頂部側明調域 apical light ...
- A centrocyte generally refers to a B cell with a cleaved nucleus, as may appear in e.g. follicular lymphoma. It can also refer to a cell with a protoplasm that contains single and double granules of varying size stainable with hematoxylin, as seen ...
Related Pictures
★リンクテーブル★
[★]
- 英
- lymph node (Z), lymph gland
- ラ
- lymphonodus
- 扁平楕円
- 直径3cm
- 脂肪組織で覆われた先生結合組織でできた被膜に包まれる
- リンパ管の合流部にできる
- 構造は大まかに3層:皮質、傍皮質、髄質。
- リンパの流れ:輸入リンパ管→辺縁洞→中間洞→髄洞→輸出リンパ管
解剖
-
-
-
- リンパ球は暗調域-(中心芽細胞から中心細胞(sIgを発現)へ)→基底明調域→頂部側明調域と移動する
- 傍皮質:ヘルパーT細胞が活性化すると傍髄質臥拡大し、髄質の深部まで伸びてくる。 ←胸腺依存領域とも呼ばれる
:*T細胞
臨床関連
- EBウイルスに感染したB細胞に対する細胞障害性T細胞が傍皮質で観察される
- The characteristic lymph node changes in AIDS are progressive transformation of the germinal centers.
参考
- http://minds.jcqhc.or.jp/stc/0053/1/0053_G0000152_0061.html
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[★]
- 英
- centrocyte
- 関
- 中心細胞