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1. 変形性関節症の初回薬物療法 initial pharmacologic therapy of osteoarthritis
2. 過敏性腸症候群に対するアロセトロン塩酸塩（Lotronex） alosetron hydrochloride lotronex for irritable bowel syndrome
3. 成人における急性咽頭炎の対症療法 symptomatic treatment of acute pharyngitis in adults
4. コーガン症候群 cogans syndrome
5. 局所麻酔剤に対するアレルギー反応 allergic reactions to local anesthetics

Ibáñez L1, Vidal X, Ballarín E, Laporte JR.
Archives of internal medicine.Arch Intern Med.2005 Apr 25;165(8):869-74.
BACKGROUND: Since the publication of a major international case-control study on the risk of agranulocytosis associated with the use of medicines in the 1980s, many new drugs have been introduced in therapeutics.METHODS: Seventeen units of hematology contribute to the case-control surveillance of ag
PMID 15851637

Characterization of a novel missense mutation in the pore of HERG in a patient with long QT syndrome.

Yoshida H1, Horie M, Otani H, Takano M, Tsuji K, Kubota T, Fukunami M, Sasayama S.
Journal of cardiovascular electrophysiology.J Cardiovasc Electrophysiol.1999 Sep;10(9):1262-70.
INTRODUCTION: A new strategy to elucidate the molecular mechanisms underlying the long QT syndrome (LQTS) is now available with genetic mutational analyses and characterization of ion channel mutations.METHODS AND RESULTS: In a 26-year-old woman with LQTS, we identified a novel missense mutation in
PMID 10517660

A model study of time- and voltage-dependent effects of class I antiarrhythmic drugs in guinea-pig papillary muscles as related to external potassium concentration.

Hamamoto T1, Kojima M, Matsuzaki M, Kusukawa R, Ban T.
Arzneimittel-Forschung.Arzneimittelforschung.1994 Aug;44(8):929-37.
1. A piecewise exponential three-state model previously introduced by the authors in 5.4 mmol/l was intended to apply to states with different [K+]o and with a different drug. Using the conventional microelectrode technique the effects of 20 mumol/l mexiletine (MEX), 5 mumol/l aprindine (APR), 20 mu
PMID 7945535

古久保拓,山川健次郎,坪庭直樹,松永千春,根来早紀子,和泉智,前川きよし,山川智之
医療薬学 34(9), 871-875, 2008-09-10
… We present two cases of markedly decreased serum aprindine levels during anti-tuberculous therapy. … Case 1 was a 65-year-old man with end-stage renal disease (ESRD) on regular dialysis who was being treated for atrial fibrillation with oral aprindine (40mg/day). … In the 6-month period before treatment with anti-tuberculous drugs, the mean serum aprindine concentration had been 1.01(SD0.31)μg/mL(n=6). …
NAID 110006946029

出雲和秀,岸雅子,黄文懋,板岡慶憲
心臓 34(Supplement4), 34-36, 2002
【目的】Pafのremodellingに対するアプリンジンの有効性が指摘されている.今回,高齢者のPafに対するアプリンジン使用の有効性と安全性を検討した.<BR>【方法】年齢72-89歳(平均年齢81.5歳),の8人(男性6人,女性2人)を対象にした.使用期間,使用量などを含め投与後の発作回数など比較した.<BR>【結果】1)アプリンジン使用年数は1年6カ月-6年1カ月で …
NAID 130004415016