WordNet

use recreational drugs (同)do drugs
administer a drug to; "They drugged the kidnapped tourist" (同)dose
a substance that is used as a medicine or narcotic
a drug that prevents or alleviates nausea and vomiting (同)antiemetic_drug

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『薬』,薬品,薬剤 / 『麻薬』,麻酔剤 / 〈人〉‘に'薬(特に麻酔剤)を与える / 〈飲食物〉‘に'(麻酔薬・毒薬などの)薬を混ぜる

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1. 制吐剤の特性 characteristics of antiemetic drugs
2. 悪心および嘔吐を伴う成人に対するアプローチ approach to the adult with nausea and vomiting
3. 化学療法誘発性悪心および嘔吐の予防および治療 prevention and treatment of chemotherapy induced nausea and vomiting
4. Anesthesia for tonsillectomy with or without adenoidectomy in children
5. 悪心および嘔吐を呈する幼児または小児に対するアプローチ approach to the infant or child with nausea and vomiting

English Journal

Chemotherapy, targeted agents, antiemetics and growth-factors in human milk: How should we counsel cancer patients about breastfeeding?

Pistilli B, Bellettini G, Giovannetti E, Codacci-Pisanelli G, Azim HA Jr, Benedetti G, Sarno MA, Peccatori FA.SourceFertility and Procreation in Oncology Unit, Department of Medicine, European Institute of Oncology, Milan, Italy; Division of Medical Oncology, Ospedale di Macerata, Macerata, Italy.
Cancer treatment reviews.Cancer Treat Rev.2013 May;39(3):207-11. doi: 10.1016/j.ctrv.2012.10.002. Epub 2012 Nov 28.
An increasing number of women are diagnosed with cancer during pregnancy and lactation. Women are usually advised to interrupt breastfeeding during systemic anticancer treatment for fear of serious adverse effects to the nursed infant. However, the issue is poorly addressed in the literature and ver
PMID 23199900

Analgesic and antiemetic requirements after minimally invasive surgery for early cervical cancer: a comparison between laparoscopy and robotic surgery.

Soliman PT, Langley G, Munsell MF, Vaniya HA, Frumovitz M, Ramirez PT.SourceDepartment of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA, psoliman@mdanderson.org.
Annals of surgical oncology.Ann Surg Oncol.2013 Apr;20(4):1355-9. doi: 10.1245/s10434-012-2681-z. Epub 2012 Oct 5.
BACKGROUND: Women with early cervical cancer undergoing radical hysterectomy via minimally invasive surgery (MIS) have decreased blood loss and a shorter hospital stay compared with laparotomy. It remains unclear whether there is a difference in benefit to the patient between robotic surgery and tra
PMID 23054117

Adherence to national guidelines for antiemesis prophylaxis in patients undergoing chemotherapy for lung cancer: A population-based study.

Gomez DR, Liao KP, Giordano S, Nguyen H, Smith BD, Elting LS.SourceDepartment of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. dgomez@mdanderson.org.
Cancer.Cancer.2013 Apr 1;119(7):1428-1436. doi: 10.1002/cncr.27899. Epub 2012 Dec 4.
BACKGROUND: Nausea and vomiting (N/V) during chemotherapy can have profound clinical and economic consequences. Effective antiemetic agents are available for prophylaxis, but barriers may prevent their use. For this population-based study, the authors assessed the rates of antiemetic prophylaxis use
PMID 23212885

Japanese Journal

Antiemetic Effects of a Potent and Selective Neurokinin-1 Receptor Antagonist, FK886, on Cisplatin- and Apomorphine-Induced Emesis in Dogs

Yoshino Furukawa Takako,Nakayama Hiroe,Kikuchi Aya,Imazumi Katsunori,Yamakuni Hisashi,Sogabe Hajime,Yamasaki Sachiko,Takeshita Koji,Matsuo Masahiko,Manda Toshitaka,Uchida Wataru
Biological and Pharmaceutical Bulletin 36(6), 974-979, 2013
… The antiemetic properties of a novel neurokinin-1 (NK1) receptor antagonist, FK886 ([3,5-bis(trifluoromethyl)phenyl][(2R)-2-(3-hydroxy-4-methylbenzyl)-4-{2-[(2S)-2-(methoxymethyl)morpholin-4-yl]ethyl}piperazin-1-yl]methanone dihydrochloride), were studied in dog models of cisplatin- and apomorphine-induced emesis. … Furthermore, FK886 showed rapid onset of antiemetic activity after oral administration. …
NAID 130003361444

Method for Individualized Evaluation of Antiemetic Effect Induced by 5-HT3 Receptor Antagonist

Nakamura Hironori,Yokoyama Haruko,Yoshimoto Koichi,Nakajima Akihiro,Okuyama Kiyoshi,Iwase Osamu,Yamada Yasuhiko
Biological and Pharmaceutical Bulletin 36(5), 780-787, 2013
… 5-HT3 receptor antagonists are widely used for prevention of chemotherapy-induced nausea and vomiting, though their antiemetic effects vary among patients. … We investigated a method for evaluation of antiemetic effects in individual patients. …
NAID 130003361432

Effectiveness and Safety of Antiemetic Aprepitant in Japanese Patients Receiving High-Dose Chemotherapy Prior to Autologous Hematopoietic Stem Cell Transplantation

Uchida Mayako,Ikesue Hiroaki,Miyamoto Toshihiro,Kato Koji,Suetsugu Kimitaka,Ichinose Kimiko,Hiraiwa Hiromi,Sakurai Asako,Takenaka Katsuto,Muta Tsuyoshi,Iwasaki Hiromi,Teshima Takanori,Shiratsuchi Motoaki,Egashira Nobuaki,Akashi Koichi,Oishi Ryozo
Biological and Pharmaceutical Bulletin 36(5), 819-824, 2013
… For patients receiving high-dose chemotherapy, a 5-hydroxytryptamine 3 receptor antagonist combined with dexamethasone is a standard antiemetic therapy. … In this study, we retrospectively evaluated the antiemetic effectiveness and safety of aprepitant (a neurokinin-1 receptor antagonist) in addition to 5-HT3 antagonist in Japanese patients with hematologic malignancy receiving high-dose chemotherapy prior to autologous peripheral blood stem cell transplantation (auto-PBSCT). …
NAID 130003361413

「鎮吐薬」

　　[★]

英: antiemetic drug, antiemetic,antiemetic drugs, antinauseant
同: 制吐薬 "鎮吐"の方が一般的らしい
関: 薬理学、鎮吐薬一覧、セロトニン受容体、嘔吐

語尾が"-setron"

抗セロトニン薬

GOO. 1000-
嘔吐が起こるのは
　①嘔吐中枢
　　延髄、網様体背外側部
　②chemoreceptor trigger zone(CTz)
　　第4脳室
　　ジキタリスが刺激

　中枢性嘔吐：嘔吐中枢とCTzを刺激
　反射性嘔吐：消化管→求心路→嘔吐中枢

　抗ガン剤投与時に起きる吐き気の機序
　①血中に入った抗ガン剤が直接CTzを刺激
　②抗癌剤により腸管細胞(enterochromaffin cell)から化学神経伝達物質が生産され、CTzを経てあるいは直接嘔吐中枢に作用する。

　中枢神経終末にある5-HT3受容体を介して嘔吐が起こる