angiotensinogen

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アンギオテンシノゲン

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/05/05 07:03:21」(JST)

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英文文献

  • An evolving story of angiotensin-II-forming pathways in rodents and humans.
  • Ferrario CM, Ahmad S, Nagata S, Simington SW, Varagic J, Kon N, Dell'italia LJ.Author information §Birmingham Veterans Affair Medical Center, University of Alabama Medical Center, Alabama, AL 35294, U.S.A.AbstractLessons learned from the characterization of the biological roles of Ang-(1-7) [angiotensin-(1-7)] in opposing the vasoconstrictor, proliferative and prothrombotic actions of AngII (angiotensin II) created an underpinning for a more comprehensive exploration of the multiple pathways by which the RAS (renin-angiotensin system) of blood and tissues regulates homoeostasis and its altered state in disease processes. The present review summarizes the progress that has been made in the novel exploration of intermediate shorter forms of angiotensinogen through the characterization of the expression and functions of the dodecapeptide Ang-(1-12) [angiotensin-(1-12)] in the cardiac production of AngII. The studies reveal significant differences in humans compared with rodents regarding the enzymatic pathway by which Ang-(1-12) undergoes metabolism. Highlights of the research include the demonstration of chymase-directed formation of AngII from Ang-(1-12) in human left atrial myocytes and left ventricular tissue, the presence of robust expression of Ang-(1-12) and chymase in the atrial appendage of subjects with resistant atrial fibrillation, and the preliminary observation of significantly higher Ang-(1-12) expression in human left atrial appendages.
  • Clinical science (London, England : 1979).Clin Sci (Lond).2014 Apr 1;126(7):461-9. doi: 10.1042/CS20130400.
  • Lessons learned from the characterization of the biological roles of Ang-(1-7) [angiotensin-(1-7)] in opposing the vasoconstrictor, proliferative and prothrombotic actions of AngII (angiotensin II) created an underpinning for a more comprehensive exploration of the multiple pathways by which the RAS
  • PMID 24329563
  • Cushing's disease and hypertension: in vivo and in vitro study of the role of the renin-angiotensin-aldosterone system and effects of medical therapy.
  • van der Pas R, van Esch JH, de Bruin C, Danser AH, Pereira AM, Zelissen PM, Netea-Maier R, Sprij-Mooij DM, van den Berg-Garrelds IM, van Schaik RH, Lamberts SW, van den Meiracker AH, Hofland LJ, Feelders RA.Author information Division of Endocrinology.AbstractOBJECTIVE/METHODS: Cushing's disease (CD) is often accompanied by hypertension. CD can be treated surgically and, given the expression of somatostatin subtype 5 and dopamine 2 receptors by corticotroph pituitary adenomas, pharmacologically. Indeed, we recently observed that stepwise medical combination therapy with the somatostatin-analog pasireotide, the dopamine-agonist cabergoline, and ketoconazole (which directly suppresses steroidogenesis) biochemically controlled CD patients and lowered their blood pressure after 80 days. Glucocorticoids (GC) modulate the renin-angiotensin-aldosterone system (RAAS) among others by increasing hepatic angiotensinogen expression and stimulating mineralocorticoid receptors (MR). This study therefore evaluated plasma RAAS components in CD patients before and after drug therapy. In addition, we studied whether cabergoline/pasireotide have direct relaxant effects in angiotensin II (Ang II)-constricted iliac arteries of spontaneously hypertensive rats, with and without concomitant GR/MR stimulation with dexamethasone or hydrocortisone.
  • European journal of endocrinology / European Federation of Endocrine Societies.Eur J Endocrinol.2014 Feb 1;170(2):181-91. doi: 10.1530/EJE-13-0477. Print 2014.
  • OBJECTIVE/METHODS: Cushing's disease (CD) is often accompanied by hypertension. CD can be treated surgically and, given the expression of somatostatin subtype 5 and dopamine 2 receptors by corticotroph pituitary adenomas, pharmacologically. Indeed, we recently observed that stepwise medical combinat
  • PMID 24165019
  • High glucose induces activation of the local renin‑angiotensin system in glomerular endothelial cells.
  • Peng H1, Xing YF2, Ye ZC1, Li CM1, Luo PL1, Li M1, Lou TQ1.Author information 1Department of Internal Medicine, Division of Nephrology, The Third Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong 510630, P.R. China.2Department of Internal Medicine, Division of Nephrology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China.AbstractActivation of the intrarenal renin‑angiotensin system (RAS), which has been identified in podocytes and mesangial cells, is a novel mechanism in the progression of diabetic kidney disease (DKD). The present study aimed to identify the local RAS in glomerular endothelial cells (GEnCs). Rat GEnCs were stimulated by culture medium containing 30 mmol/l glucose for 12, 24, 48 and 72 h. Angiotensin II (Ang II) concentrations in cell lysates and culture media were examined by ELISA and mRNA levels of angiotensinogen and renin in cell lysates were analyzed by quantitative polymerase chain reaction. Ang II type 1 receptor (AT1R), Ang II type 2 receptor (AT2R), renin and angiotensinogen levels in cell lysates were determined by western blot analysis. Localization of intracellular AT1R, AT2R, angiotensinogen and renin was identified by confocal immunofluorescence microscopy. Consequently, high glucose (HG) increased intracellular and extracellular Ang II levels. Captopril and chymostatin (inhibitor of chymase, an enzyme that converts Ang I to Ang II) were able to antagonize HG‑induced Ang II generation. Moreover, HG increased angiotensinogen production in GEnCs and reduced renin mRNA expression without altering renin protein production. However, HG decreased AT1R levels and resulted in AT2R shifting from the nuclear to perinuclear region in GEnCs. In conclusion, HG activated the intracellular RAS in rat GEnCs and the underlying mechanism may involve angiotensin‑converting enzyme (ACE) and non‑ACE pathways. The effects of HG on GEnCs may also involve the substrate and receptors of Ang II.
  • Molecular medicine reports.Mol Med Rep.2014 Feb;9(2):450-6. doi: 10.3892/mmr.2013.1855. Epub 2013 Dec 10.
  • Activation of the intrarenal renin‑angiotensin system (RAS), which has been identified in podocytes and mesangial cells, is a novel mechanism in the progression of diabetic kidney disease (DKD). The present study aimed to identify the local RAS in glomerular endothelial cells (GEnCs). Rat GEnCs
  • PMID 24337709

和文文献

  • 慢性腎臓病 (特集 RAAS研究の進歩 : RAASの新知見) -- (RAAS抑制薬の有用性)
  • Urinary Angiotensinogen as a Novel Early Biomarker of Intrarenal Renin-Angiotensin System Activation in Experimental Type 1 Diabetes
  • KAMIYAMA Masumi,ZSOMBOK Andrea,KOBORI Hiroyuki
  • Journal of pharmacological sciences 119(4), 314-323, 2012-08-20
  • NAID 10031071403
  • Association between the angiotensinogen gene T174M polymorphism and hypertension risk in the Chinese population : a meta-analysis
  • GO Wei,LIU Ya,WANG Zuoguang,LIU Kuo,LOU Yuqing,NIU Qiuli,WANG Hao,LIU Jinghua,WEN Shaojun
  • Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 35(1), 70-76, 2012-01-01
  • NAID 10030642954

関連リンク

Human Total Angiotensinogen Assay Kit - IBL 96 well ¥120,000 取扱説明書 IBL 27413-96well IB3083 Mouse Total Angiotensinogen Assay Kit - IBL 96 well ¥120,000 取扱説明書 IBL 27414-96well IB3085 Rat Total 96 well IBL ...
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Medical Dictionary angiotensinogen an·gi·o·ten·sin·o·gen (ān'jē-ō-těn-sĭn'ə-jən) n. A serum globulin formed by the liver that is cleaved by renin to form angiotensin I. Also called angiotensin precursor. The American Heritage® Stedman ...

関連画像

 cells using anti-Angiotensinogen antibodyRenin AngiotensinogenAngiotensinogen (Hypertensinogen; Renin Angiotensinogen and its complex with renin  Angiotensinogen is excreted from the livFigure 1: Angiotensinogen and


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リンク元アンギオテンシノゲン」「アンギオテンシン前駆体」「アンジオテンシン前駆体

アンギオテンシノゲン」

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angiotensinogen
アンジオテンシノジェン、アンギオテンシノーゲン、アンギオテンシノジェン、アンジオテンシノゲン
レニン-アンギオテンシン-アルドステロン系


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産生組織

  • 肝臓
α2グロブリン分画中

標的組織

作用

分泌の調整

分子機構

アンギオテンシン前駆体」

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angiotensinogen
アンギオテンシノーゲンアンジオテンシノーゲンアンジオテンシン前駆体


アンジオテンシン前駆体」

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angiotensinogen
アンギオテンシノーゲンアンジオテンシノーゲンアンギオテンシン前駆体




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