アンジオテンシンII受容体、アンギオテンシンII受容体、アンジオテンシンIIレセプター、アンギオテンシンIIレセプター

関: angiotensin receptor

WordNet

the 9th letter of the Roman alphabet (同)i
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
any of several vasoconstrictor substances (trade name Hypertensin) that cause narrowing of blood vessels (同)angiotonin, Hypertensin

PrepTutorEJDIC

『私は』私が
iodineの化学記号
=sense organ / 受信装置

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/09/08 22:03:52」(JST)

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The angiotensin receptors are a class of G protein-coupled receptors with angiotensin II as their ligands.^[1] They are important in the renin-angiotensin system: they are responsible for the signal transduction of the vasoconstricting stimulus of the main effector hormone, angiotensin II.^[2]

Structure

The AT₁ and AT₂ receptors share a sequence identity of ~30%, but have a similar affinity for angiotensin II, which is their main ligand.

Members

Overview table

Receptor	Mechanism^[3]
AT₁	G_q/11 G_i/o
AT₂	G_i2 / ₃
AT₃
AT₄

Losartan is a selective AT1 antagonist,while PD123177 is a selective AT2 antagonist.Both subtypes are G-protein coupled receptor.

AT₁

The AT₁ receptor is the best elucidated angiotensin receptor.

Location within the body

The AT1 subtype is found in the heart, blood vessels, kidney, adrenal cortex, lung and brain and mediates the vasoconstrictor effects.

Mechanism

The angiotensin receptor is activated by the vasoconstricting peptide angiotensin II. The activated receptor in turn couples to G_q/11 and G_i/o and thus activates phospholipase C and increases the cytosolic Ca²⁺ concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. Activated receptor also inhibits adenylate cyclase and activates various tyrosine kinases.^[2]

Effects

Effects mediated by the AT₁ receptor include vasoconstriction, aldosterone synthesis and secretion, increased vasopressin secretion, cardiac hypertrophy, augmentation of peripheral noradrenergic activity, vascular smooth muscle cells proliferation, decreased renal blood flow, renal renin inhibition, renal tubular sodium reuptake, modulation of central sympathetic nervous system activity, cardiac contractility, central osmocontrol and extracellular matrix formation.^[4]

AT₂

AT₂ receptors are more plentiful in the fetus and neonate. The AT₂ receptor remains enigmatic and controversial – is probably involved in vascular growth. Effects mediated by the AT₂ receptor are suggested to include inhibition of cell growth, fetal tissue development, modulation of extracellular matrix, neuronal regeneration, apoptosis, cellular differentiation, and maybe vasodilation and left ventricular hypertrophy.^[5]

AT₃ and AT₄

Other poorly characterized subtypes include the AT₃ and AT₄ receptors. The AT₄ receptor is activated by the angiotensin II metabolite angiotensin IV, and may play a role in regulation of the CNS extracellular matrix, as well as modulation of oxytocin release.^[6]^[7]^[8]^[9]^[10]^[11]^[12]^[13]

References

^ de Gasparo M, Catt KJ, Inagami T, Wright JW, Unger T (2000). "International union of pharmacology. XXIII. The angiotensin II receptors". Pharmacol. Rev. 52 (3): 415–72. PMID 10977869.
^ ^a ^b Higuchi S, Ohtsu H, Suzuki H, Shirai H, Frank GD, Eguchi S (2007). "Angiotensin II signal transduction through the AT1 receptor: novel insights into mechanisms and pathophysiology". Clin. Sci. 112 (8): 417–28. doi:10.1042/CS20060342. PMID 17346243.
^ Unless else specified in box, then ref is: Senselab
^ Catt KJ, Mendelsohn FA, Millan MA, Aguilera G (1984). "The role of angiotensin II receptors in vascular regulation". J. Cardiovasc. Pharmacol. 6 (Suppl 4): S575–86. doi:10.1097/00005344-198406004-00004. PMID 6083400.
^ D'Amore A, Black MJ, Thomas WG (December 2005). "The angiotensin II type 2 receptor causes constitutive growth of cardiomyocytes and does not antagonize angiotensin II type 1 receptor-mediated hypertrophy however they do imply that myocardial infarction increase hypertension in arthritis with hyperkalemia". Hypertension. 46 (6): 1347–54. doi:10.1161/01.HYP.0000193504.51489.cf. PMID 16286564.
^ Albiston AL, Mustafa T, McDowall SG, Mendelsohn FA, Lee J, Chai SY (March 2003). "AT4 receptor is insulin-regulated membrane aminopeptidase: potential mechanisms of memory enhancement". Trends Endocrinol. Metab. 14 (2): 72–7. doi:10.1016/S1043-2760(02)00037-1. PMID 12591177.
^ Chai SY, Fernando R, Peck G, Ye SY, Mendelsohn FA, Jenkins TA, Albiston AL (November 2004). "The angiotensin IV/AT4 receptor". Cell. Mol. Life Sci. 61 (21): 2728–37. doi:10.1007/s00018-004-4246-1. PMID 15549174.
^ Davis CJ, Kramár EA, De A, Meighan PC, Simasko SM, Wright JW, Harding JW (2006). "AT4 receptor activation increases intracellular calcium influx and induces a non-N-methyl-D-aspartate dependent form of long-term potentiation". Neuroscience. 137 (4): 1369–79. doi:10.1016/j.neuroscience.2005.10.051. PMID 16343778.
^ Vanderheyden PM (April 2009). "From angiotensin IV binding site to AT4 receptor". Mol. Cell. Endocrinol. 302 (2): 159–66. doi:10.1016/j.mce.2008.11.015. PMID 19071192.
^ Beyer CE, Dwyer JM, Platt BJ, Neal S, Luo B, Ling HP, Lin Q, Mark RJ, Rosenzweig-Lipson S, Schechter LE (May 2010). "Angiotensin IV elevates oxytocin levels in the rat amygdala and produces anxiolytic-like activity through subsequent oxytocin receptor activation". Psychopharmacology (Berl.). 209 (4): 303–11. doi:10.1007/s00213-010-1791-1. PMID 20224888.
^ Andersson H (2010). Design and Synthesis of Angiotensin IV Peptidomimetics Targeting the Insulin-Regulated Aminopeptidase (IRAP) (Ph.D. thesis). Uppsala Universitet. Retrieved 2012-01-08.
^ Wright JW, Harding JW (September 2011). "Brain renin-angiotensin—a new look at an old system". Prog. Neurobiol. 95 (1): 49–67. doi:10.1016/j.pneurobio.2011.07.001. PMID 21777652.
^ Benoist CC, Wright JW, Zhu M, Appleyard SM, Wayman GA, Harding JW (October 2011). "Facilitation of hippocampal synaptogenesis and spatial memory by C-terminal truncated Nle1-angiotensin IV analogs". J. Pharmacol. Exp. Ther. 339 (1): 35–44. doi:10.1124/jpet.111.182220. PMC 3186286. PMID 21719467.

External links

Receptors, Angiotensin at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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1. アンギオテンシン変換酵素阻害剤およびアンギオテンシンII受容体拮抗剤の主な副作用 major side effects of angiotensin converting enzyme inhibitors and angiotensin ii receptor blockers
2. 駆出率低下を伴う心不全におけるアンギオテンシンⅡ受容体拮抗剤およびネプリライシン阻害剤の使用 use of angiotensin ii receptor blocker and neprilysin inhibitor in heart failure with reduced ejection fraction
3. 心臓におけるアンギオテンシンⅡの作用 actions of angiotensin ii on the heart
4. 収縮能障害による心不全の治療の概要 overview of the therapy of heart failure due to systolic dysfunction
5. 不安定狭心症および非ST上昇型心筋梗塞の非急性期マネージメントの概要 overview of the non acute management of unstable angina and non st elevation myocardial infarction

English Journal

Design of a dual-function peptide probe as a binder of angiotensin II and an inducer of silver nanoparticle aggregation for use in label-free colorimetric assays.

Okochi M1, Kuboyama M2, Tanaka M3, Honda H2.
Talanta.Talanta.2015 Sep 1;142:235-239. doi: 10.1016/j.talanta.2015.04.054. Epub 2015 Apr 27.
Label-free colorimetric assays using metallic nanoparticles have received much recent attention, for their application in simple and sensitive methods for detection of biomolecules. Short peptide probes that can bind to analyte biomolecules are attractive ligands in molecular nanotechnology; however
PMID 26003717

Activation of μ opioid receptors in the LPBN facilitates sodium intake in rats.

Pavan CG1, Roncari CF1, Barbosa SP1, De Paula PM1, Colombari DS1, De Luca LA Jr1, Colombari E1, Menani JV2.
Behavioural brain research.Behav Brain Res.2015 Jul 15;288:20-5. doi: 10.1016/j.bbr.2015.03.047. Epub 2015 Mar 28.
Important inhibitory mechanisms for the control of water and sodium intake are present in the lateral parabrachial nucleus (LPBN). Opioid receptors are expressed by LPBN neurons and injections of β-endorphin (nonspecific opioid receptor agonist) in this area induce 0.3M NaCl and water intake in sat
PMID 25827924

Angiotensin receptor I stimulates osteoprogenitor proliferation through TGFβ-mediated signaling.

Querques F1, Cantilena B, Cozzolino C, Esposito MT, Passaro F, Parisi S, Lombardo B, Russo T, Pastore L.
Journal of cellular physiology.J Cell Physiol.2015 Jul;230(7):1466-74. doi: 10.1002/jcp.24887.
Clinical studies of large human populations and pharmacological interventions in rodent models have recently suggested that anti-hypertensive drugs that target angiotensin II (Ang II) activity may also reduce loss of bone mineral density. Here, we identified in a genetic screening the Ang II type I
PMID 25556973

Japanese Journal

Significance of the Vascular Concentration of Angiotensin Ⅱ-Receptor Blockers on the Mechanism of Lowering Blood Pressure in Spontaneously Hypertensive Rats

Takai Shinji,Jin Denan,Sakonjo Hiroshi [他]
Journal of pharmacological sciences 123(4), 371-379, 2013-12
NAID 40019923941

3) 血管内皮から観た妊娠高血圧症候群の病態とその発症予知(シンポジウム2:周産期「妊娠高血圧症候群の基礎と臨床-予防・治療の新戦略に向けて」,第65回日本産科婦人科学会・学術講演会)

松原圭一
日本産科婦人科學會雜誌 65(11), 2591-2603, 2013-11-01
… The increase of NADPH oxidase mRNA was inhibited by anti TNFα antibody or angiotensin II (AngII) receptor subtype 1 blocker (AT1 blocker). …
NAID 110009674983

3) 血管内皮から観た妊娠高血圧症候群の病態とその発症予知(シンポジウム2:周産期「妊娠高血圧症候群の基礎と臨床-予防・治療の新戦略に向けて」,第65回日本産科婦人科学会・学術講演会)

松原圭一
日本産科婦人科學會雜誌 65(11), 2591-2603, 2013-11-01
… The increase of NADPH oxidase mRNA was inhibited by anti TNFα antibody or angiotensin II (AngII) receptor subtype 1 blocker (AT1 blocker). …
NAID 110009661871

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リンク元	「アンジオテンシンII受容体」「アンギオテンシンII受容体」「アンギオテンシンIIレセプター」「アンジオテンシンIIレセプター」
拡張検索	「angiotensin II receptor blocker」
関連記事	「II」「I」「angiotensin II」「angiotensin」

「アンジオテンシンII受容体」

angiotensin II receptor, type 2
Identifiers
Symbol	AGTR2
IUPHAR	35
Entrez	186
HUGO	338
OMIM	300034
RefSeq	NM_000686
UniProt	P50052
Other data
Locus	Chr. X q22-q23

angiotensin II receptor, type 1
Identifiers
Symbol	AGTR1
Alt. symbols	AGTR1B
IUPHAR	34
Entrez	185
HUGO	336
OMIM	106165
RefSeq	NM_000685
UniProt	P30556
Other data
Locus	Chr. 3 q21-q25