alternate splicing

出典: meddic


  • 一つの遺伝子からイントロン除去部位の違いにより異なる複数のタンパク質が生成する現象

alternative RNA splicingalternative splicing

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/02/05 23:01:45」(JST)

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  • The role of tissue factor isoforms in cancer biology.
  • Leppert U1, Eisenreich A1.
  • International journal of cancer. Journal international du cancer.Int J Cancer.2015 Aug 1;137(3):497-503. doi: 10.1002/ijc.28959. Epub 2014 May 16.
  • Tissue Factor (TF) is an evolutionary conserved glycoprotein, which is of immense importance for a variety of biologic processes. TF is expressed in two naturally occurring protein isoforms, membrane-bound "full-length" (fl)TF and soluble alternatively spliced (as)TF. The TF isoform expression is di
  • PMID 24806794
  • An overview of molecular basis of iron metabolism regulation and the associated pathologies.
  • Silva B1, Faustino P2.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2015 Jul;1852(7):1347-1359. doi: 10.1016/j.bbadis.2015.03.011. Epub 2015 Apr 2.
  • Iron is essential for several vital biological processes. Its deficiency or overload drives to the development of several pathologies. To maintain iron homeostasis, the organism controls the dietary iron absorption by enterocytes, its recycling by macrophages and storage in hepatocytes. These proces
  • PMID 25843914
  • The transducible TAT-RIZ1-PR protein exerts histone methyltransferase activity and tumor-suppressive functions in human malignant meningiomas.
  • Ding MH1, Wang Z2, Jiang L1, Fu HL3, Gao J4, Lin XB1, Zhang CL3, Liu ZY5, Shi YF4, Qiu GZ1, Ma Y3, Cui DX3, Hu GH6, Jin WL7.
  • Biomaterials.Biomaterials.2015 Jul;56:165-78. doi: 10.1016/j.biomaterials.2015.03.058. Epub 2015 Apr 17.
  • Malignant meningiomas are a rare meningioma subtype and tend to have post-surgical recurrence. Significant endeavors have been taken to identify functional therapeutic targets to halt the growth of this aggressive cancer. We have recently discovered that RIZ1 is downregulated in high-grade meningiom
  • PMID 25934289


  • Multiple Messenger Ribonucleic Acid Transcripts and Revised Gene Organization of the Human TSH Receptor
  • Endocrine journal 49(2), 175-180, 2002-04
  • NAID 10008361228
  • Alternate splicing in the cytosolic II-III loop and the carboxy terminus of human E-type voltage-gated Ca^<2+> channels : electrophysiological characterization of isoforms


... -coding portions of the sequence, called introns, must be removed and protein-coding parts, called exons, joined by RNA splicing to produce a mature mRNA. The discovery of alternative splicing RNA splicing was first Figure 1). ...
切手は種類により料金が異なっている 葉書や封筒を相手に贈るときには送るときの料金が必要になるのですが、その料金を払った証明として使用することができるのが切手になります。切手は郵便局やコンビニなどでお金を払って購入 ...


sourceah yes alternate splicing of the pre figure 4 alternative splicing regulation figure 1 types of alternative splicing in in many cases an elaborate molecular splicing is a conserved mechanism

リンク元alternative RNA splicing

alternative RNA splicing」


alternate splicingalternative splicing



  • adj.
  • 交代性の、交互の、交替する

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「go back and forth; swing back and forth between two states or conditions」

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「do something in turns; "We take turns on the night shift"」
take turns

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「of leaves and branches etc; first on one side and then on the other in two ranks along an axis; not paired; "stems with alternate leaves"」

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「『交互の』,かわるがわるの / 一つおきの(every other) / 代わりの,どれか一つの / 《米》代わり[の人](substitute) / 〈両者が〉交替する;(…と)交替する,互い違いになる《+『with』+『名』》 / …'を'交互にさせる」

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「occurring by turns; first one and then the other; "alternating feelings of love and hate"」

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「serving or used in place of another; "an alternative plan"」
alternative, substitute

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「every second one of a series; "the cleaning lady comes on alternate Wednesdays"; "jam every other day"- the White Queen」

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「exchange people temporarily to fulfill certain jobs and functions」



  • adj.
  • 交代性の

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「(of a current) reversing direction; "alternating current"」

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