WordNet

make fit for, or change to suit a new purpose; "Adapt our native cuisine to the available food resources of the new country" (同)accommodate
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"

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NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients.

Johann S1, Heitzer M1, Kanagaratnam M1, Goswami A2, Rizo T2, Weis J2, Troost D3, Beyer C1.
Glia.Glia.2015 Dec;63(12):2260-73. doi: 10.1002/glia.22891. Epub 2015 Jul 21.
Amyotrophic lateral sclerosis (ALS) is characterized by the degeneration of motoneurons in the cerebral cortex, brainstem and spinal cord. Neuroinflammation plays an important role in the pathogenesis of ALS and involves the activation of microglia and astrocytes. Intracellular inflammasome complexe
PMID 26200799

Purinergic Modulation of Spinal Neuroglial Maladaptive Plasticity Following Peripheral Nerve Injury.

Cirillo G1, Colangelo AM2,3, Berbenni M2,3, Ippolito VM2,3, De Luca C1, Verdesca F1, Savarese L1, Alberghina L2,3, Maggio N4,5, Papa M6,7.
Molecular neurobiology.Mol Neurobiol.2015 Dec;52(3):1440-57. doi: 10.1007/s12035-014-8943-y. Epub 2014 Oct 29.
Modulation of spinal reactive gliosis following peripheral nerve injury (PNI) is a promising strategy to restore synaptic homeostasis. Oxidized ATP (OxATP), a nonselective antagonist of purinergic P2X receptors, was found to recover a neuropathic behavior following PNI. We investigated the role of i
PMID 25352445

The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd.

Peintner L1, Dorstyn L2, Kumar S2, Aneichyk T3, Villunger A1, Manzl C1,4.
Cell death and differentiation.Cell Death Differ.2015 Nov;22(11):1803-11. doi: 10.1038/cdd.2015.31. Epub 2015 Apr 10.
The receptor-interacting protein-associated ICH-1/CED-3 homologous protein with a death domain (RAIDD/CRADD) functions as a dual adaptor and is a constituent of different multi-protein complexes implicated in the regulation of inflammation and cell death. Within the PIDDosome complex, RAIDD connects
PMID 25857265

A Distinct Role of Riplet-Mediated K63-Linked Polyubiquitination of the RIG-I Repressor Domain in Human Antiviral Innate Immune Responses

Oshiumi Hiroyuki,Miyashita Moeko,Matsumoto Misako,Seya Tsukasa
Plos pathogens 9(8), e1003533, 2013-08
… TRIM25 is required for RIG-I oligomerization and interaction with the IPS-1 adaptor molecule. … Mutational analysis demonstrated that Lys-788 within the RIG-I repressor domain was critical for Riplet-mediated K63-linked polyubiquitination and that Riplet was required for the release of RIG-I autorepression of its N-terminal CARDs, which leads to the association of RIG-I with TRIM25 ubiquitin ligase and TBK1 protein kinase. …
NAID 120005326762

Editor-in-Chief's choice : The AP-1 μ Adaptin is Required for KNOLLE Localization at the Cell Plate to Mediate Cytokinesis in Arabidopsis

Functional Characterization of Domains of IPS-1 Using an Inducible Oligomerization System.

Takamatsu Shiori,Onoguchi Kazuhide,Onomoto Koji,Narita Ryo,Takahasi Kiyohiro,Ishidate Fumiyoshi,Fujiwara Takahiro K,Yoneyama Mitsutoshi,Kato Hiroki,Fujita Takashi
PloS one 8(1), 2013-01-07
… Once cells are infected with a virus, RIG-I and MDA5 bind to viral RNA and undergo conformational change to transmit a signal through direct interaction with downstream CARD-containing adaptor protein, IFN-β promoter stimulator-1 (IPS-1, also referred as MAVS/VISA/Cardif). …
NAID 120005241348