アシルCoA・コレステロールアシルトランスフェラーゼ、アシルCoA・コレステロールアシル基転移酵素
WordNet
- the 3rd letter of the Roman alphabet (同)c
- (music) the keynote of the scale of C major
- a general-purpose programing language closely associated with the UNIX operating system
- an animal sterol that is normally synthesized by the liver; the most abundant steroid in animal tissues (同)cholesterin
- any group or radical of the form RCO- where R is an organic group; "an example of the acyl group is the acetyl group" (同)acyl_group
PrepTutorEJDIC
- carbonの化学記号
- コレステロール(胆汁・血液・神経組織などの脂肪性成分)
- cobaltの化学記号
UpToDate Contents
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- 1. リポ蛋白の分類、代謝、およびアテローム性動脈硬化症における役割 lipoprotein classification metabolism and role in atherosclerosis
- 2. HDL代謝およびHDLコレステロール値異常の患者に対するアプローチ hdl metabolism and approach to the patient with abnormal hdl cholesterol levels
- 3. ペルオキシソーム病 peroxisomal disorders
- 4. 代謝性ミオパチーの原因 causes of metabolic myopathies
- 5. 棘状細胞（棘状赤血球および有棘赤血球）と標的細胞 spiculated cells echinocytes and acanthocytes and target cells
English Journal
- Synthesis of 24(S)-hydroxycholesterol esters responsible for the induction of neuronal cell death.
- Shibuya K1, Watanabe T2, Urano Y3, Takabe W3, Noguchi N3, Kitagishi H4.
- Bioorganic & medicinal chemistry.Bioorg Med Chem.2016 Jun 1;24(11):2559-66. doi: 10.1016/j.bmc.2016.04.024. Epub 2016 Apr 12.
- We synthesized several candidates of 24(S)-hydroxycholesterol (24S-OHC) esters, which are involved in neuronal cell death, through catalysis with acyl-CoA:cholesterol acyltransferase-1 (ACAT-1). We studied the regioselectivity of the acylation of the secondary alcohol at the 3- or 24-position of 24S
- PMID 27117262
- D38-cholesterol as a Raman active probe for imaging intracellular cholesterol storage.
- Alfonso-García A1, Pfisterer SG2, Riezman H3, Ikonen E2, Potma EO4.
- Journal of biomedical optics.J Biomed Opt.2016 Jun;21(6):61003. doi: 10.1117/1.JBO.21.6.061003.
- We generated a highly deuterated cholesterol analog (D38-cholesterol) and demonstrated its use for selective vibrational imaging of cholesterol storage in mammalian cells. D38-cholesterol produces detectable signals in stimulated Raman scattering (SRS) imaging, is rapidly taken up by cells, and is e
- PMID 26719944
- Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer.
- Li J1, Gu D2, Lee SS1, Song B1, Bandyopadhyay S3, Chen S4, Konieczny SF3,5, Ratliff TL5,6, Liu X5,7, Xie J2, Cheng JX1,5.
- Oncogene.Oncogene.2016 May 2. doi: 10.1038/onc.2016.168. [Epub ahead of print]
- Cancer cells are known to execute reprogramed metabolism of glucose, amino acids and lipids. Here, we report a significant role of cholesterol metabolism in cancer metastasis. By using label-free Raman spectromicroscopy, we found an aberrant accumulation of cholesteryl ester in human pancreatic canc
- PMID 27132508
Japanese Journal
- Pharmacological Characterization of [trans-5′-(4-Amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-2′,3′-dihydrospiro(cyclohexane-1,1′-inden)-4-yl]acetic Acid Monobenzenesulfonate (JTT-553), a Novel Acyl CoA:Diacylglycerol Transferase (DGAT) 1 Inhibitor
- Tomimoto Daisuke,Okuma Chihiro,Ishii Yukihito [他],Akiyama Yoshiyuki,Ohta Takeshi,Kakutani Makoto,Ohkuma Yoshiaki,Ogawa Nobuya
- Biological and Pharmaceutical Bulletin 38(2), 263-269, 2015
- … Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 is an enzyme that catalyzes the final step in triglyceride (TG) synthesis. … To measure the inhibitory activity of JTT-553 against DGAT1, TG synthesis using [14C]-labeled oleoyl-CoA was evaluated. …
- NAID 130004872263
- アミド軸不斉の化学 : 生物活性発現に寄与する立体構造の解明研究
- 田畑 英嗣
- 薬学雑誌 133(8), 853-866, 2013
- NAID 40019778248
- The Mechanism of Action of Bufalin in Inhibition of Lipid Droplet Accumulation in Mouse Macrophages
- Kobayashi Keisuke,Ohshiro Taichi,Matsuda Daisuke [他],Jiang Wei,Hong Bin,Si Shuyi,Tomoda Hiroshi
- Biological and Pharmaceutical Bulletin 36(3), 364-369, 2013
- … Bufalin selectively inhibited synthesis of [14C]cholesteryl ester (CE), a main component of lipid droplet, from [14C]oleic acid and [14C]cholesterol with IC50 values of 8.6 µM and 10 µM, respectively. … The postlysosomal metabolism of cholesterol to CE in macrophages was also inhibited by the compound with a similar IC50 value of 13.2 µM. …
- NAID 130003382077
Related Links
- Sterol O-acyltransferase is an intracellular protein located in the endoplasmic reticulum that forms cholesterol esters from ... Thus, the two substrates of this enzyme are acyl-CoA and cholesterol, whereas its two products are CoA and ...
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★リンクテーブル★
| リンク元 | 「アシルCoA・コレステロールアシルトランスフェラーゼ」「sterol O-acyltransferase」「アシルCoA・コレステロールアシル基転移酵素」 |
| 関連記事 | 「C」「acyltransferase」「CoA」「COA」「cholesterol」 |
「アシルCoA・コレステロールアシルトランスフェラーゼ」
- 英
- acyl-CoA-cholesterol acyltransferase、ACAT
- 関
- アシルCoA・コレステロールアシル基転移酵素、ステロールO-アシルトランスフェラーゼ、コレステロールアシルトランスフェラーゼ
「sterol O-acyltransferase」
ステロールO-アシルトランスフェラーゼ、ステロールO-アシル基転移酵素、ステロールO-アシル転移酵素
「アシルCoA・コレステロールアシル基転移酵素」
「C」
- 炭素 carbon
- シトシン cytosine
- システイン cysteine
- シチジン
- セルシウス度 摂氏 degrees Celsius degree C
- 産婦人科領域で「子宮外頚 子宮外頚部 exocervix」を表現するための略語