acyl-CoA-cholesterol acyltransferase

出典: meddic

アシルCoA・コレステロールアシルトランスフェラーゼアシルCoA・コレステロールアシル基転移酵素

ACATcholesterol acyltransferasesterol O-acyltransferase

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英文文献

  • Synthesis of 24(S)-hydroxycholesterol esters responsible for the induction of neuronal cell death.
  • Shibuya K1, Watanabe T2, Urano Y3, Takabe W3, Noguchi N3, Kitagishi H4.
  • Bioorganic & medicinal chemistry.Bioorg Med Chem.2016 Jun 1;24(11):2559-66. doi: 10.1016/j.bmc.2016.04.024. Epub 2016 Apr 12.
  • We synthesized several candidates of 24(S)-hydroxycholesterol (24S-OHC) esters, which are involved in neuronal cell death, through catalysis with acyl-CoA:cholesterol acyltransferase-1 (ACAT-1). We studied the regioselectivity of the acylation of the secondary alcohol at the 3- or 24-position of 24S
  • PMID 27117262
  • D38-cholesterol as a Raman active probe for imaging intracellular cholesterol storage.
  • Alfonso-García A1, Pfisterer SG2, Riezman H3, Ikonen E2, Potma EO4.
  • Journal of biomedical optics.J Biomed Opt.2016 Jun;21(6):61003. doi: 10.1117/1.JBO.21.6.061003.
  • We generated a highly deuterated cholesterol analog (D38-cholesterol) and demonstrated its use for selective vibrational imaging of cholesterol storage in mammalian cells. D38-cholesterol produces detectable signals in stimulated Raman scattering (SRS) imaging, is rapidly taken up by cells, and is e
  • PMID 26719944
  • Abrogating cholesterol esterification suppresses growth and metastasis of pancreatic cancer.
  • Li J1, Gu D2, Lee SS1, Song B1, Bandyopadhyay S3, Chen S4, Konieczny SF3,5, Ratliff TL5,6, Liu X5,7, Xie J2, Cheng JX1,5.
  • Oncogene.Oncogene.2016 May 2. doi: 10.1038/onc.2016.168. [Epub ahead of print]
  • Cancer cells are known to execute reprogramed metabolism of glucose, amino acids and lipids. Here, we report a significant role of cholesterol metabolism in cancer metastasis. By using label-free Raman spectromicroscopy, we found an aberrant accumulation of cholesteryl ester in human pancreatic canc
  • PMID 27132508

和文文献

  • Pharmacological Characterization of [trans-5′-(4-Amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-2′,3′-dihydrospiro(cyclohexane-1,1′-inden)-4-yl]acetic Acid Monobenzenesulfonate (JTT-553), a Novel Acyl CoA:Diacylglycerol Transferase (DGAT) 1 Inhibitor
  • Tomimoto Daisuke,Okuma Chihiro,Ishii Yukihito [他],Akiyama Yoshiyuki,Ohta Takeshi,Kakutani Makoto,Ohkuma Yoshiaki,Ogawa Nobuya
  • Biological and Pharmaceutical Bulletin 38(2), 263-269, 2015
  • Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 is an enzyme that catalyzes the final step in triglyceride (TG) synthesis. … To measure the inhibitory activity of JTT-553 against DGAT1, TG synthesis using [14C]-labeled oleoyl-CoA was evaluated. …
  • NAID 130004872263
  • アミド軸不斉の化学 : 生物活性発現に寄与する立体構造の解明研究
  • The Mechanism of Action of Bufalin in Inhibition of Lipid Droplet Accumulation in Mouse Macrophages
  • Kobayashi Keisuke,Ohshiro Taichi,Matsuda Daisuke [他],Jiang Wei,Hong Bin,Si Shuyi,Tomoda Hiroshi
  • Biological and Pharmaceutical Bulletin 36(3), 364-369, 2013
  • … Bufalin selectively inhibited synthesis of [14C]cholesteryl ester (CE), a main component of lipid droplet, from [14C]oleic acid and [14C]cholesterol with IC50 values of 8.6 µM and 10 µM, respectively. … The postlysosomal metabolism of cholesterol to CE in macrophages was also inhibited by the compound with a similar IC50 value of 13.2 µM. …
  • NAID 130003382077

関連リンク

Sterol O-acyltransferase is an intracellular protein located in the endoplasmic reticulum that forms cholesterol esters from ... Thus, the two substrates of this enzyme are acyl-CoA and cholesterol, whereas its two products are CoA and ...

関連画像

acyl coa cholesterol acyltransferaseacyltransferase (Acyl-CoA-Cholesterol  the lecithin:cholesterol acyltransferaseAcyl-coenzyme A:cholesterol acyl-coa cholesterol acyltransferaseACAT2 and Dr. Lawrence L. Rudel


★リンクテーブル★
先読みACAT
リンク元アシルCoA・コレステロールアシルトランスフェラーゼ」「sterol O-acyltransferase」「アシルCoA・コレステロールアシル基転移酵素
関連記事C」「cholesterol」「acyl」「acyltransferase」「Co

ACAT」

  [★]

acyl-CoA:cholesterol acyltransferase
Cholesterol acyltransferase
acy卜CoA, xholestero1


アシルCoA・コレステロールアシルトランスフェラーゼ」

  [★]

acyl-CoA-cholesterol acyltransferaseACAT
アシルCoA・コレステロールアシル基転移酵素ステロールO-アシルトランスフェラーゼコレステロールアシルトランスフェラーゼ


sterol O-acyltransferase」

  [★]

ステロールO-アシルトランスフェラーゼステロールO-アシル基転移酵素ステロールO-アシル転移酵素

acyl-CoA-cholesterol acyltransferasecholesterol acyltransferase


アシルCoA・コレステロールアシル基転移酵素」

  [★]

acyl-CoA-cholesterol acyltransferase
アシルCoA・コレステロールアシルトランスフェラーゼ


C」

  [★]

WordNet   license wordnet

「the 3rd letter of the Roman alphabet」
c

WordNet   license wordnet

「(music) the keynote of the scale of C major」

WordNet   license wordnet

「a general-purpose programing language closely associated with the UNIX operating system」

PrepTutorEJDIC   license prepejdic

「carbonの化学記号」

cholesterol」

  [★] コレステロール

WordNet   license wordnet

「an animal sterol that is normally synthesized by the liver; the most abundant steroid in animal tissues」
cholesterin

PrepTutorEJDIC   license prepejdic

「コレステロール(胆汁・血液・神経組織などの脂肪性成分)」


acyl」

  [★]

アシル

WordNet   license wordnet

「any group or radical of the form RCO- where R is an organic group; "an example of the acyl group is the acetyl group"」
acyl group


acyltransferase」

  [★]

アシルトランスフェラーゼアシル転移酵素アシル基転移酵素

transacylase


Co」

  [★] コバルト cobalt

PrepTutorEJDIC   license prepejdic

「cobaltの化学記号」



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