TSH receptor

• 甲状腺刺激ホルモン受容体、甲状腺刺激ホルモンレセプター、TSH受容体、TSHレセプター

関

thyroid-stimulating hormone receptor、thyrotropin receptor

WordNet

1. the 20th letter of the Roman alphabet (同)t
2. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

1. tritiumの化学記号
2. =sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/04 16:19:54」(JST)

wiki en

[Wiki en表示]

Not to be confused with Thyrotropin-releasing hormone or Thyrotropin-releasing hormone receptor.

Thyroid stimulating hormone receptor
Rendering based on PDB 1XUM.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1XUM, 2XWT, 3G04
Identifiers
Symbols	TSHR ; CHNG1; LGR3; hTSHR-I
External IDs	OMIM: 603372 MGI: 98849 HomoloGene: 315 IUPHAR: 255 ChEMBL: 1963 GeneCards: TSHR Gene
Gene ontology Molecular function • thyroid-stimulating hormone receptor activity • protein binding • G-protein coupled peptide receptor activity Cellular component • plasma membrane • integral component of plasma membrane • receptor complex Biological process • G-protein coupled receptor signaling pathway • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • adenylate cyclase-activating G-protein coupled receptor signaling pathway • activation of adenylate cyclase activity • cell-cell signaling • positive regulation of cell proliferation • hormone-mediated signaling pathway • thyroid-stimulating hormone signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	7253	22095
Ensembl	ENSG00000165409	ENSMUSG00000020963
UniProt	P16473	P47750
RefSeq (mRNA)	NM_000369	NM_001113404
RefSeq (protein)	NP_000360	NP_001106875
Location (UCSC)	Chr 14: 80.95 – 81.15 Mb	Chr 12: 91.4 – 91.54 Mb
PubMed search	[1]	[2]

The thyrotropin receptor (or TSH receptor) is a receptor (and associated protein) that responds to thyroid-stimulating hormone (also known as "thyrotropin") and stimulates the production of thyroxine (T4) and triiodothyronine (T3). The TSH receptor is a member of the G protein-coupled receptor superfamily of integral membrane proteins and is coupled to the G_s protein.

It is primarily found on the surface of the thyroid epithelial cells.

Function

Upon binding circulating thyrotropin, a G-protein signal cascade activates adenylyl cyclase and intercellular levels of cAMP rise. cAMP activates all functional aspects of the thyroid cell, including iodine pumping; thyroglobulin synthesis, iodination, endocytosis and proteolysis; thyroid peroxidase activity; and hormone release.

See also

• Graves' disease

References

Further reading

• Führer D, Wonerow P, Willgerodt H, Paschke R (1998). "Identification of a new thyrotropin receptor germline mutation (Leu629Phe) in a family with neonatal onset of autosomal dominant nonautoimmune hyperthyroidism.". J. Clin. Endocrinol. Metab. 82 (12): 4234–8. doi:10.1210/jc.82.12.4234. PMID 9398746. 
• Farid NR, Kascur V, Balazs C (2000). "The human thyrotropin receptor is highly mutable: a review of gain-of-function mutations.". Eur. J. Endocrinol. 143 (1): 25–30. doi:10.1530/eje.0.1430025. PMID 10870027. 
• Szkudlinski MW, Fremont V, Ronin C, Weintraub BD (2002). "Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships.". Physiol. Rev. 82 (2): 473–502. doi:10.1152/physrev.00031.2001. PMID 11917095. 
• Tonacchera M, Vitti P, De Servi M, et al. (2004). "Gain of function TSH receptor mutations and iodine deficiency: implications in iodine prophylaxis.". J. Endocrinol. Invest. 26 (2 Suppl): 2–6. PMID 12762632. 
• Arturi F, Scarpelli D, Coco A, et al. (2004). "Thyrotropin receptor mutations and thyroid hyperfunctioning adenomas ten years after their first discovery: unresolved questions.". Thyroid 13 (4): 341–3. doi:10.1089/105072503321669811. PMID 12804102. 
• Vaidya B, Campbell V, Tripp JH, et al. (2004). "Premature birth and low birth weight associated with nonautoimmune hyperthyroidism due to an activating thyrotropin receptor gene mutation.". Clin. Endocrinol. (Oxf) 60 (6): 711–8. doi:10.1111/j.1365-2265.2004.02040.x. PMID 15163335. 
• Takeshita A, Nagayama Y, Fujiyama K, et al. (1992). "Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript.". Biochem. Biophys. Res. Commun. 188 (3): 1214–9. doi:10.1016/0006-291X(92)91360-3. PMID 1445355. 
• Graves PN, Tomer Y, Davies TF (1992). "Cloning and sequencing of a 1.3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain.". Biochem. Biophys. Res. Commun. 187 (2): 1135–43. doi:10.1016/0006-291X(92)91315-H. PMID 1530609. 
• Loosfelt H, Pichon C, Jolivet A, et al. (1992). "Two-subunit structure of the human thyrotropin receptor". Proc. Natl. Acad. Sci. U.S.A. 89 (9): 3765–9. doi:10.1073/pnas.89.9.3765. PMC 525571. PMID 1570295. 
• Nagayama Y, Russo D, Wadsworth HL, et al. (1991). "Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding". J. Biol. Chem. 266 (23): 14926–30. PMID 1651314. 
• Murakami M, Mori M (1990). "Identification of immunogenic regions in human thyrotropin receptor for immunoglobulin G of patients with Graves' disease". Biochem. Biophys. Res. Commun. 171 (1): 512–8. doi:10.1016/0006-291X(90)91423-P. PMID 1697467. 
• Heldin NE, Gustavsson B, Westermark K, Westermark B (1992). "A somatic point mutation in a putative ligand binding domain of the TSH receptor in a patient with autoimmune hyperthyroidism". J. Clin. Endocrinol. Metab. 73 (6): 1374–6. doi:10.1210/jcem-73-6-1374. PMID 1955520. 
• Libert F, Passage E, Lefort A, et al. (1991). "Localization of human thyrotropin receptor gene to chromosome region 14q3 by in situ hybridization". Cytogenet. Cell Genet. 54 (1–2): 82–3. doi:10.1159/000132964. PMID 2249482. 
• Frazier AL, Robbins LS, Stork PJ, et al. (1991). "Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing". Mol. Endocrinol. 4 (8): 1264–76. doi:10.1210/mend-4-8-1264. PMID 2293030. 
• Misrahi M, Loosfelt H, Atger M, et al. (1990). "Cloning, sequencing and expression of human TSH receptor". Biochem. Biophys. Res. Commun. 166 (1): 394–403. doi:10.1016/0006-291X(90)91958-U. PMID 2302212. 
• Nagayama Y, Kaufman KD, Seto P, Rapoport B (1990). "Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor". Biochem. Biophys. Res. Commun. 165 (3): 1184–90. doi:10.1016/0006-291X(89)92727-7. PMID 2558651. 
• Libert F, Lefort A, Gerard C, et al. (1990). "Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies". Biochem. Biophys. Res. Commun. 165 (3): 1250–5. doi:10.1016/0006-291X(89)92736-8. PMID 2610690. 
• Cuddihy RM, Bryant WP, Bahn RS (1996). "Normal function in vivo of a homozygotic polymorphism in the human thyrotropin receptor". Thyroid 5 (4): 255–7. doi:10.1089/thy.1995.5.255. PMID 7488864. 
• Bahn RS, Dutton CM, Heufelder AE, Sarkar G (1994). "A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves' ophthalmopathy". J. Clin. Endocrinol. Metab. 78 (2): 256–60. doi:10.1210/jc.78.2.256. PMID 7508946. 
• Sunthornthepvarakui T, Gottschalk ME, Hayashi Y, Refetoff S (1995). "Brief report: resistance to thyrotropin caused by mutations in the thyrotropin-receptor gene". N. Engl. J. Med. 332 (3): 155–60. doi:10.1056/NEJM199501193320305. PMID 7528344. 

External links

• "Glycoprotein Hormone Receptors: TSH". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. 
• Thyrotropin Receptors at the US National Library of Medicine Medical Subject Headings (MeSH)
• GRIS: Glycoprotein-hormone Receptor Information System

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. バセドウ病（グレーブス病）の発症機序 pathogenesis of graves disease
• 2. 甲状腺刺激ホルモンおよび甲状腺刺激ホルモン放出ホルモンに対する抵抗性 resistance to thyrotropin and thyrotropin releasing hormone
• 3. 甲状腺ホルモンの合成および生理 thyroid hormone synthesis and physiology
• 4. 橋本病（慢性自己免疫性甲状腺炎）の病因 pathogenesis of hashimotos thyroiditis chronic autoimmune thyroiditis
• 5. 新生児グレーヴス病の評価およびマネージメント evaluation and management of neonatal graves disease

English Journal

• JNK pathway decreases thyroid hormones via TRH receptor: A novel mechanism for disturbance of thyroid hormone homeostasis by PCB153.

• Liu C, Ha M, Cui Y, Wang C, Yan M, Fu W, Quan C, Zhou J, Yang K.SourceMOE Key Lab of Environment and Health, Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, PR China.
• Toxicology.Toxicology.2012 Dec 8;302(1):68-76. Epub 2012 Aug 4.
• PCBs, widespread and well-characterized endocrine disruptors, cause the disruption of thyroid hormone (TH) homeostasis in humans and animals. In order to verify the hypotheses that MAPK pathways would play roles in disturbance of TH levels caused by PCBs, and that TH-associated receptors could funct
• PMID 22889935

• Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: a dynamic and kinetic evaluation of a putative mode-of-action.

• Paul KB, Hedge JM, Bansal R, Zoeller RT, Peter R, DeVito MJ, Crofton KM.SourceUniversity of North Carolina at Chapel Hill, Curriculum in Toxicology, CB 7270, Chapel Hill, NC 27599, USA.
• Toxicology.Toxicology.2012 Oct 9;300(1-2):31-45. Epub 2012 Jun 1.
• This work tests the mode-of-action (MOA) hypothesis that maternal and developmental triclosan (TCS) exposure decreases circulating thyroxine (T4) concentrations via up-regulation of hepatic catabolism and elimination of T4. Time-pregnant Long-Evans rats received TCS po (0-300mg/kg/day) from gestatio
• PMID 22659317

Japanese Journal

• 症例 Basedow病アイソトープ治療後の甲状腺機能低下症で,抗TSH受容体抗体高値が持続する妊婦に発症した胎児・新生児Basedow病の1例

• 紅粉 睦男,井川 裕之,森 孝之 [他]
• 内科 115(3), 487-490, 2015-03
• NAID 40020369820

• 橋本病甲状腺機能低下症と甲状腺抗体 : TPOAb,TGAb,ブロッキング抗体TSBAb

• 髙須 信行
• 日本体質医学会雑誌 = The Japanese journal of constitutional medicine 77(1), 6-13, 2015-02
• NAID 40020373456

• TSH resistance revisited [Review]

• Narumi Satoshi,Hasegawa Tomonobu
• Endocrine Journal 62(5), 393-398, 2015
• … One example of such defects is TSH resistance, which is caused by biallelic inactivating mutations in the TSH receptor gene (TSHR). … TSH, a master regulator of thyroid functions, affects virtually all cellular processes involving thyroid hormone production, including thyroidal iodine uptake, thyroglobulin iodination, reuptake of iodinated thyroglobulin and thyroid cell growth. …
• NAID 130005071792

Related Links

• TSHレセプター抗体 - エスアールエル 医療従事者向けサイト ご ...

TSHレセプターは分子量約100kDaの糖蛋白で,この蛋白にTSHが結合すると活性化され刺激が伝達される。このレセプターに対する自己抗体が自己免疫性甲状腺疾患(バセドウ病,及び甲状腺機能低下症の一部)の患者血中に認められる。

• 甲状腺病因検査 甲状腺自己抗体検査 | 金地病院

病因を特定するには、抗サイログロブリン抗体（TgAb）、抗ペルオキシダーゼ抗体（TPOAb）、TSHレセプター抗体（TRAb）の三項目の検査が必要です。 に対する自己抗体です。 橋本病やバセドウ病では、この自己抗体が高く検出 ...

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★リンクテーブル★

リンク元	「甲状腺刺激ホルモン受容体」「thyroid-stimulating hormone receptor」「TSHレセプター」
拡張検索	「TSH receptor antibody」
関連記事	「TS」「T」「TSH」

「甲状腺刺激ホルモン受容体」

　　[★]

英

thyroid-stimulating hormone receptor thyrotropin receptor TSH receptor TSH-R

関

サイロトロピン受容体 thyrotropin receptor TR、TSH受容体、TSHレセプター、甲状腺刺激ホルモンレセプター、サイロトロピンレセプター

甲状腺刺激ホルモン TSH、甲状腺、下垂体前葉

「thyroid-stimulating hormone receptor」

　　[★]

• 甲状腺刺激ホルモン受容体、甲状腺刺激ホルモンレセプター

関

thyrotropin receptor、TSH receptor

「TSHレセプター」

　　[★]

英

TSH receptor

関

甲状腺刺激ホルモン受容体、TSH受容体、甲状腺刺激ホルモンレセプター

「TSH receptor antibody」

　　[★] 甲状腺刺激ホルモンレセプター抗体

「TS」

　　[★]

• 三尖弁狭窄 三尖弁狭窄症 tncuspicl stenosis
• 結節性硬化症 tuberous sclerosis = TSC
• トゥレット症候群 Tourette syndrome
• =Ts サプレッサーT細胞 suppressor T cell

「T」

　　[★]

• T波 T wave
• チミン thymine
• ツイスト数
• スレオニントレオニン threonine

　 　

「TSH」

　　[★] 甲状腺刺激ホルモン