SARS

出典: meddic

重症急性呼吸器症候群 severe acute respiratory syndrome

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/11/09 14:59:20」(JST)

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/08/10 12:58:31」(JST)

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英文文献

  • Activity of and effect of subcutaneous treatment with the broad-spectrum antiviral lectin griffithsin in two laboratory rodent models.
  • Barton C, Kouokam JC, Lasnik AB, Foreman O, Cambon A, Brock G, Montefiori DC, Vojdani F, McCormick AA, O'Keefe BR, Palmer KE.Author information Department of Pharmacology and Toxicology and James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA.AbstractGriffithsin (GRFT) is a red-alga-derived lectin that binds the terminal mannose residues of N-linked glycans found on the surface of human immunodeficiency virus type 1 (HIV-1), HIV-2, and other enveloped viruses, including hepatitis C virus (HCV), severe acute respiratory syndrome coronavirus (SARS-CoV), and Ebola virus. GRFT displays no human T-cell mitogenic activity and does not induce production of proinflammatory cytokines in treated human cell lines. However, despite the growing evidence showing the broad-spectrum nanomolar or better antiviral activity of GRFT, no study has reported a comprehensive assessment of GRFT safety as a potential systemic antiviral treatment. The results presented in this work show that minimal toxicity was induced by a range of single and repeated daily subcutaneous doses of GRFT in two rodent species, although we noted treatment-associated increases in spleen and liver mass suggestive of an antidrug immune response. The drug is systemically distributed, accumulating to high levels in the serum and plasma after subcutaneous delivery. Further, we showed that serum from GRFT-treated animals retained antiviral activity against HIV-1-enveloped pseudoviruses in a cell-based neutralization assay. Overall, our data presented here show that GRFT accumulates to relevant therapeutic concentrations which are tolerated with minimal toxicity. These studies support further development of GRFT as a systemic antiviral therapeutic agent against enveloped viruses, although deimmunizing the molecule may be necessary if it is to be used in long-term treatment of chronic viral infections.
  • Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2014 Jan;58(1):120-7. doi: 10.1128/AAC.01407-13. Epub 2013 Oct 21.
  • Griffithsin (GRFT) is a red-alga-derived lectin that binds the terminal mannose residues of N-linked glycans found on the surface of human immunodeficiency virus type 1 (HIV-1), HIV-2, and other enveloped viruses, including hepatitis C virus (HCV), severe acute respiratory syndrome coronavirus (SARS
  • PMID 24145548
  • Cell-based antiviral screening against coronaviruses: Developing virus-specific and broad-spectrum inhibitors.
  • Kilianski A1, Baker SC2.Author information 1Department of Microbiology and Immunology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, United States.2Department of Microbiology and Immunology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, United States. Electronic address: sbaker1@lumc.edu.AbstractTo combat the public health threat from emerging coronaviruses (CoV), the development of antiviral therapies with either virus-specific or pan-coronaviral activities is necessary. An important step in antiviral drug development is the screening of potential inhibitors in cell-based systems. The recent emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) necessitates adapting methods that have been used to identify antivirals against severe acute respiratory syndrome coronavirus (SARS-CoV) and developing new approaches to more efficiently screen antiviral drugs. In this article we review cell-based assays using infectious virus (BSL-3) and surrogate assays (BSL-2) that can be implemented to accelerate antiviral development against MERS-CoV and future emergent coronaviruses. This paper forms part of a series of invited articles in Antiviral Research on "From SARS to MERS: 10years of research on highly pathogenic human coronaviruses."
  • Antiviral research.Antiviral Res.2014 Jan;101:105-12. doi: 10.1016/j.antiviral.2013.11.004. Epub 2013 Nov 20.
  • To combat the public health threat from emerging coronaviruses (CoV), the development of antiviral therapies with either virus-specific or pan-coronaviral activities is necessary. An important step in antiviral drug development is the screening of potential inhibitors in cell-based systems. The rece
  • PMID 24269477
  • SARS-CoV ORF1b-encoded nonstructural proteins 12-16: Replicative enzymes as antiviral targets.
  • Subissi L1, Imbert I1, Ferron F1, Collet A1, Coutard B1, Decroly E1, Canard B2.Author information 1Laboratoire Architecture et Fonction des Macromolécules Biologiques (AFMB), UMR 7257 - CNRS et Aix-Marseille Université, ESIL Case 925, 13288 Marseille, France.2Laboratoire Architecture et Fonction des Macromolécules Biologiques (AFMB), UMR 7257 - CNRS et Aix-Marseille Université, ESIL Case 925, 13288 Marseille, France. Electronic address: bruno.canard@afmb.univ-mrs.fr.AbstractThe SARS (severe acute respiratory syndrome) pandemic caused ten years ago by the SARS-coronavirus (SARS-CoV) has stimulated a number of studies on the molecular biology of coronaviruses. This research has provided significant new insight into many mechanisms used by the coronavirus replication-transcription complex (RTC). The RTC directs and coordinates processes in order to replicate and transcribe the coronavirus genome, a single-stranded, positive-sense RNA of outstanding length (∼27-32kilobases). Here, we review the up-to-date knowledge on SARS-CoV replicative enzymes encoded in the ORF1b, i.e., the main RNA-dependent RNA polymerase (nsp12), the helicase/triphosphatase (nsp13), two unusual ribonucleases (nsp14, nsp15) and RNA-cap methyltransferases (nsp14, nsp16). We also review how these enzymes co-operate with other viral co-factors (nsp7, nsp8, and nsp10) to regulate their activity. These last ten years of research on SARS-CoV have considerably contributed to unravel structural and functional details of one of the most fascinating replication/transcription machineries of the RNA virus world. This paper forms part of a series of invited articles in Antiviral Research on "From SARS to MERS: 10years of research on highly pathogenic human coronaviruses".
  • Antiviral research.Antiviral Res.2014 Jan;101:122-30. doi: 10.1016/j.antiviral.2013.11.006. Epub 2013 Nov 20.
  • The SARS (severe acute respiratory syndrome) pandemic caused ten years ago by the SARS-coronavirus (SARS-CoV) has stimulated a number of studies on the molecular biology of coronaviruses. This research has provided significant new insight into many mechanisms used by the coronavirus replication-tran
  • PMID 24269475

和文文献

  • Public Health : Group B Betacoronavirus in Rhinolophid Bats, Japan
  • SUZUKI Jin,SATO Ryota,KOBAYASHI Tomoya [他]
  • The journal of veterinary medical science 76(9), 1267-1269, 2014-09
  • NAID 40020214688
  • 病院からの排水 (特集 まるごと見直す! ICTのための院内の「水」の管理と対策 AtoZ : 水道水,医療用水,無菌水,排水,災害対策など)
  • 角 晴輝
  • Infection control : The Japanese journal of infection control 23(9), 860-866, 2014-09
  • NAID 40020200943
  • Quantification and Verification of Whole-Body-Average SARs in Small Animals Exposed to Electromagnetic Fields inside Reverberation Chamber
  • SHI Jingjing,CHAKAROTHAI Jerdvisanop,WANG Jianqing,WAKE Kanako,WATANABE Soichi,FUJIWARA Osamu
  • IEICE Transactions on Communications E97.B(10), 2184-2191, 2014
  • … This paper aims to achieve a high-quality exposure level quantification of whole-body average-specific absorption rates (WBA-SARs) for small animals in a medium-size reverberation chamber (RC). … In order to clarify the validity of the two-step method, we compare the physical quantities in terms of electric field strength and WBA-SARs by using a direct numerical assessment method known as the method of moments (MoM) with ten homogenous gel phantoms placed in an RC with 2GHz exposure. …
  • NAID 130004696696

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★リンクテーブル★
リンク元重症急性呼吸器症候群」「severe acute respiratory syndrome
関連記事SA」「SAR

重症急性呼吸器症候群」

  [★]

severe acute respiratory syndrome SARS

歴史

  • 2002年11月から2003年2月まで中国広東省に多数の感染者が発生し、香港、ハノイ、カナダ、シンガポール台湾で感染が拡大

病原体

疫学

感染経路

  • 飛沫感染  空気感染ではない
  • 病初期にウイルスの排出量は少ない

症状

  • 38℃以上の発熱、悪寒、咳、呼吸困難、頭痛、下痢、全身倦怠感など


severe acute respiratory syndrome」

  [★] 重症急性呼吸器症候群 SARS


SA」

  [★]

WordNet   license wordnet

「Nazi militia created by Hitler in 1921 that helped him to power but was eclipsed by the SS after 1943」
Sturmabteilung, Storm Troops


SAR」

  [★]


seasonal allergic rhinitis


"http://meddic.jp/SARS" より作成


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