PGH synthase

出典: meddic

cyclo-oxygenasecyclooxygenaseprostaglandin H synthaseprostaglandin synthase、prostaglandin synthetase、prostaglandin-endoperoxide synthase

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  • Reinterpreting the best biomarker of oxidative stress: The 8-iso-prostaglandin F2α/prostaglandin F2α ratio shows complex origins of lipid peroxidation biomarkers in animal models.
  • Van't Erve TJ1, Lih FB2, Jelsema C3, Deterding LJ2, Eling TE4, Mason RP5, Kadiiska MB5.
  • Free radical biology & medicine.Free Radic Biol Med.2016 Jun;95:65-73. doi: 10.1016/j.freeradbiomed.2016.03.001. Epub 2016 Mar 8.
  • Oxidative stress is elevated in numerous environmental exposures and diseases. Millions of dollars have been spent to try to ameliorate this damaging process using anti-oxidant therapies. Currently, the best accepted biomarker of oxidative stress is the lipid oxidation product 8-iso-prostaglandin F2
  • PMID 26964509
  • Resveratrol preferentially inhibits IgE-dependent PGD2 biosynthesis but enhances TNF production from human skin mast cells.
  • Shirley D1, McHale C2, Gomez G3.
  • Biochimica et biophysica acta.Biochim Biophys Acta.2016 Apr;1860(4):678-85. doi: 10.1016/j.bbagen.2016.01.006. Epub 2016 Jan 14.
  • BACKGROUND: Resveratrol, a natural polyphenol found in the skin of red grapes, is reported to have anti-inflammatory properties including protective effects against aging. Consequently, Resveratrol is a common nutritional supplement and additive in non-prescription lotions and creams marketed as ant
  • PMID 26777630
  • Concerted actions of ameliorated colitis, aberrant crypt foci inhibition and 15-hydroxyprostaglandin dehydrogenase induction by sonic hedgehog inhibitor led to prevention of colitis-associated cancer.
  • Kangwan N1,2, Kim YJ3, Han YM1, Jeong M1, Park JM1, Hahm KB1,4.
  • International journal of cancer.Int J Cancer.2016 Mar 15;138(6):1482-93. doi: 10.1002/ijc.29892. Epub 2015 Oct 30.
  • The sonic hedgehog (Shh) signaling has been known to contribute to carcinogenesis in organ, where hedgehog exerted organogenesis and in cancers, which are developed based on mutagenic inflammation. Therefore, colitis-associated cancer (CAC) can be a good model to prove whether Shh inhibitors can be
  • PMID 26476372


  • リポカリン型プロスタグランジンD合成酵素のリガンド認識機構
  • 島本 茂,吉田 卓也,大久保 忠恭
  • YAKUGAKU ZASSHI 131(11), 1575-1581, 2011
  • …   Lipocalin-type prostaglandin (PG) D synthase (L-PGDS) is a multi functional protein acting as a PGD2 synthesizing enzyme, a transporter or scavenger of various lipophilic ligands, and an amyloid β chaperon in the brain. … In this study, we determined by NMR the structure of recombinant mouse L-PGDS and L-PGDS/PGH2 analog complex. …
  • NAID 130001491111
  • 触媒機能におけるシトクロムP450配位構造の必然性 : モデル錯体からのアプローチ
  • 樋口 恒彦
  • 有機合成化学協会誌 67(2), 134-142, 2009-02-01
  • … We have succeeded in the preparation of the first synthetic thiolato-iron porphyrin (SR complex) that retains its structure during catalytic oxidation.Experiments using SR complex have revealed that the thiolate ligand greatly accelerates the rate of the O-O bond cleavage and its heterolysis even in highly hydrophobic media.Prostaglandin H2 (PGH2) is catalytically isomerized to prostacyclin or thromboxane A2 by cytochrome P450s. …
  • NAID 10024967641
  • Antiplatelet Effect of NQ12 : a Possible Mechanism Through the Arachidonic Acid Cascade
  • JIN Yong-Ri,HAN Xiang-Hua,LEE Jung-Jin,LIM Yong,KIM Tack-Joong,YOO Hwan-Soo,HONG Jin-Tae,LEE Chong-Kil,YUN Yeo-Pyo
  • Journal of pharmacological sciences 105(2), 193-200, 2007-10-20
  • … Further study revealed that NQ12 potently suppressed AA-mediated TXA2 formation, but had no effect on the PGD2 production, indicating an inhibitory effect on TXA2 synthase, which was supported by a TXA2 synthase activity assay indicating that NQ12 concentration-dependently inhibited TXA2 formation converted from PGH2. …
  • NAID 10024316390


NSAIDs, COX-Independent Actions ... Editors Gerald F. Gebhart Robert F. Schmidt Free Articles Telomerase Encyclopedia of Cancer Amplification Encyclopedia of Cancer Prokaryotic Genomics The Prokaryotes
1. Ann N Y Acad Sci. 1994 Nov 15;744:50-7. Interactions of PGH synthase isozymes-1 and -2 with NSAIDs. Smith WL, Meade EA, DeWitt DL. Department of Biochemistry, Michigan State University, East Lansing 48824. There are ...



リンク元プロスタグランジンH合成酵素」「prostaglandin synthase」「prostaglandin-endoperoxide synthase」「PGH合成酵素


  [★] シクロオキシゲナーゼ

WordNet   license wordnet

「either of two related enzymes that control the production of prostaglandins and are blocked by aspirin」


  [★] シクロオキシゲナーゼ



prostaglandin H synthasePGH synthase

prostaglandin synthase」


cyclo-oxygenasecyclooxygenasePGH synthaseprostaglandin H synthase、prostaglandin synthetase、prostaglandin-endoperoxide synthase

prostaglandin-endoperoxide synthase」


cyclo-oxygenasecyclooxygenasePGH synthaseprostaglandin H synthaseprostaglandin synthase、prostaglandin synthetase



PGH synthase



WordNet   license wordnet

「the 16th letter of the Roman alphabet」

PrepTutorEJDIC   license prepejdic


PrepTutorEJDIC   license prepejdic





PrepTutorEJDIC   license prepejdic

「parental guidance(映画の観客指定で)親の認可[映画]」



  • n.